MC3R and AGRP

Number of citations: 0 (PubMedID 11747427)
Data Source: HPRD (in vitro)

		MC3R	AGRP
Name		melanocortin 3 receptor	agouti related neuropeptide
Structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Type 1 Melanocortin Receptor Binding
	Biological Process	Regulation Of Heart Rate Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Rhythmic Process Sodium Ion Homeostasis Regulation Of Feeding Behavior	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Bremelanotide	None
GWAS		Adult body size ( 32376654 ) Body mass index ( 26426971 ) Body mass index (age <50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Metabolite levels ( 23823483 )	Blood protein levels ( 30072576 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 )
Interacting Genes		4 interacting genes: AGRP ASIP CFTR POMC	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		4159	181
HPRD ID		01115	09079
Ensembl ID		ENSG00000124089	ENSG00000159723
Uniprot IDs		P41968	C6SUN5 O00253
PDB IDs		8IOC 8KIG	1HYK 1MR0
GO Terms Enriched among Interactors		Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Neuropeptide Signaling Pathway Feeding Behavior Long-day Photoperiodism Melanocortin Receptor Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Transepithelial Water Transport Regulation Of Hormone Secretion Positive Regulation Of Tooth Mineralization Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Peptide Hormone Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Amelogenesis Extracellular Space ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Feeding Behavior Melanin Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Cellular Response To Forskolin	Melanocortin Receptor Activity Regulation Of Feeding Behavior Melanocyte-stimulating Hormone Receptor Activity Regulation Of Behavior Regulation Of Eating Behavior Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Secretion Peptide Secretion Feeding Behavior Hormone Transport Hormone Secretion Peptide Transport Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Homoiothermy Amide Transport Response To Melanocyte-stimulating Hormone Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Signal Release Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Blood Circulation Growth Hormone Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Corticotropin Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Gastric Acid Secretion Positive Regulation Of Growth Hormone Secretion