MAK and PPP2CB

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MAK	PPP2CB
Name		male germ cell associated kinase	protein phosphatase 2 catalytic subunit beta
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Midbody Motile Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Mitotic Spindle	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton FAR/SIN/STRIPAK Complex
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Transmembrane Transporter Binding Metal Ion Binding Tau Protein Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Cell Differentiation Intracellular Signal Transduction Intraciliary Transport Photoreceptor Cell Maintenance Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Cilium Assembly Negative Regulation Of Non-motile Cilium Assembly Non-motile Cilium Assembly	Mitotic Cell Cycle Protein Dephosphorylation Apoptotic Mitochondrial Changes Response To Lead Ion Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Microtubule Polymerization Response To Endoplasmic Reticulum Stress Response To Hydrogen Peroxide Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ras Protein Signal Transduction Response To Antibiotic Regulation Of Neurofibrillary Tangle Assembly
Pathways		None	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs		None	Vitamin E
GWAS		Menopause (age at onset) ( 26414677 ) Recurrent major depressive disorder ( 29317602 ) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261 )	Daytime sleep phenotypes ( 27126917 ) Heel bone mineral density x serum urate levels interaction ( 34046847 )
Interacting Genes		9 interacting genes: ANAPC11 APP FBXO7 FZR1 NDUFB7 PPP2CB SERINC1 SLAMF7 SND1	41 interacting genes: ACP5 AXIN1 BHLHE41 BUB1 C22orf39 DOCK7 DYNLT2B EGFR GAD1 GSTA1 HK3 KRAS LCMT1 MAK MAPT MID1 MLH1 MLH3 NRAS PACS1 PDGFRL PLXNA3 PMS2 PRKCB PTPRJ RAF1 RELA RPLP1 SGO1 SMAD4 SRC STK11 TAB1 TAB2 TGFBR2 TIPRL TLX1 TRMT61B UBC ZFP28 ZNF775
Entrez ID		4117	5516
HPRD ID		01101	01487
Ensembl ID		ENSG00000111837	ENSG00000104695
Uniprot IDs		A0A140VK28 A0A6Q8PG01 A0A6Q8PH30 F8VBW7 P20794 Q8IXN4	A0A140VJS0 P62714
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Response To Lead Ion Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Polyubiquitination Regulation Of Cell Cycle Process Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite RNAi Effector Complex Regulation Of Meiotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition G Protein-coupled Receptor Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Catabolic Process Ubiquitin-like Ligase-substrate Adaptor Activity Lewy Body Core Protein K48-linked Ubiquitination Regulation Of Cell Cycle Phase Transition DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Catabolic Process Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Intracellular Signal Transduction Mismatch Repair Complex Cellular Response To Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Response To Growth Factor MAPK Cascade Kinase Activity Mismatched DNA Binding Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Enzyme Binding Chiasma Intracellular Signaling Cassette Positive Regulation Of Multicellular Organismal Process Cytosol Regulation Of Multicellular Organismal Process ATP-dependent DNA Damage Sensor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MutLalpha Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Protein Phosphorylation ATP Binding Immune Response-activating Signaling Pathway Regulation Of Neurogenesis Regulation Of MAPK Cascade Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Morphogenesis Of A Branching Epithelium Positive Regulation Of Immune Response Positive Regulation Of Protein Modification Process Animal Organ Morphogenesis Anatomical Structure Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Developmental Process Phosphorylation Gland Morphogenesis Morphogenesis Of A Branching Structure Mismatch Repair Cell Development Nucleotide Binding Negative Regulation Of Cellular Component Organization Transferase Activity