ARSA and PPIC

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ARSA	PPIC
Name		arylsulfatase A	peptidylprolyl isomerase C
Structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Cytoplasm Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Arylsulfatase Activity Cerebroside-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity
	Biological Process	Lipid Metabolic Process	Protein Folding
Pathways		The activation of arylsulfatases Neutrophil degranulation Glycosphingolipid catabolism	None
Drugs		4-Nitrocatechol sulfate 2-Amino-3-Hydroxy-3-Phosphonooxy-Propionic Acid	Proline
Diseases		Metachromatic leukodystrophy (MLD)	None
GWAS		Aspartate aminotransferase levels ( 33547301 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 ) QT interval (ambient particulate matter interaction) ( 28749367 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) vWF and FVIII levels ( 30586737 )	Aortic root size ( 19584346 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Diverticular disease ( 30177863 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		18 interacting genes: ANXA11 BMPR2 CAMK2B CCDC22 CETN2 CLEC4G CTSL EID2B FOXI1 GAL3ST1 PKN1 POU1F1 PPIC PROP1 RHOXF2 SNCA TRIP13 VENTX	13 interacting genes: ARSA BANP CAPNS2 FAM25A FAM25C FAM25G LGALS3BP SGTA SGTB UBAP1 UBQLN1 UBQLN2 UBQLN4
Entrez ID		410	5480
HPRD ID		09617	00459
Ensembl ID		ENSG00000100299	ENSG00000168938
Uniprot IDs		A0A0C4DFZ2 B4DVI5 P15289	P45877
PDB IDs		1AUK 1E1Z 1E2S 1E33 1E3C 1N2K 1N2L 2AIJ 2AIK 2HI8	2ESL
GO Terms Enriched among Interactors		None	TRC Complex Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Protein Catabolic Process Cerebroside-sulfatase Activity Regulation Of Cellular Response To Stress Response To Endoplasmic Reticulum Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Targeting To Membrane Identical Protein Binding Autophagy Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Autophagosome Assembly BAT3 Complex Binding Autophagosome Organization Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Autophagy Calpain Complex Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cytoplasmic Vesicle Cytosolic Proteasome Complex Regulation Of Protein Metabolic Process Negative Regulation Of ERAD Pathway