SH2D1A and FYB1

Number of citations: 0 (PubMedID 12458214)
Data Source: HPRD (in vitro, in vivo)

		SH2D1A	FYB1
Name		SH2 domain containing 1A	FYN binding protein 1
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Actin Cytoskeleton Protein-containing Complex Anchoring Junction
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Signaling Receptor Binding Protein Binding Lipid Binding
	Biological Process	Adaptive Immune Response Immune System Process Humoral Immune Response Cellular Defense Response Cell-cell Signaling Natural Killer Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Immune Response Integrin-mediated Signaling Pathway T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Generation of second messenger molecules Generation of second messenger molecules Signal regulatory protein family interactions
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	None
GWAS		No GWAS studies recorded	Sleep (1/2-day periodicity) ( 33075057 )
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	16 interacting genes: BCAR1 CBL CBLB ENAH EVL FASLG FYN LCP2 NCK2 SH2D1A SKAP1 SKAP2 SRC UBC VASP WAS
Entrez ID		4068	2533
HPRD ID		02390	04107
Ensembl ID		ENSG00000183918	ENSG00000082074
Uniprot IDs		O60880	O15117
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	1RI9 2GTJ 2GTO
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Tyrosine Kinase Activity Lymphocyte Activation Positive Regulation Of Metabolic Process Cell Activation Protein Kinase Activity T Cell Activation Cell Surface Receptor Signaling Pathway Cellular Developmental Process Leukocyte Activation Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cell Differentiation Regulation Of Immune System Process ERBB Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Phosphatase Binding Regulation Of Multicellular Organismal Process Intracellular Signaling Cassette Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Ephrin Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Basal Plasma Membrane Ephrin Receptor Binding Regulation Of Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Immune System Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Lamellipodium Assembly Animal Organ Development Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response	SH3 Domain Binding Actin Filament Organization Immune System Process Leukocyte Activation T Cell Receptor Signaling Pathway Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Profilin Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Supramolecular Fiber Organization Antigen Receptor-mediated Signaling Pathway Actin Polymerization Or Depolymerization Cytosol Immune Response-activating Signaling Pathway Cytoplasm Regulation Of Immune Response Phospholipase Binding Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cellular Component Organization Response To Platelet-derived Growth Factor Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Focal Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Lymphocyte Activation Positive Regulation Of Cellular Component Organization Regulation Of Immune System Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Plasma Membrane Response To Growth Factor Regulation Of Actin Polymerization Or Depolymerization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Actin Filament Length Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Ephrin Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Signal Complex Assembly Lamellipodium Receptor Tyrosine Kinase Binding Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Junction Regulation Of Protein-containing Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction