LRP1 and RIC8B

Number of citations: 51 (PubMedID 20205790)
Data Source: BioGRID (two hybrid)

		LRP1	RIC8B
Name		LDL receptor related protein 1	RIC8 guanine nucleotide exchange factor B
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Early Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Endocytic Vesicle Membrane Receptor Complex Plasma Membrane Protein Complex	Cytoplasm Centrosome Cytosol Plasma Membrane Cell Cortex
	Molecular Function	Amyloid-beta Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Metal Ion Binding Lipoprotein Particle Receptor Binding	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity Protein Folding Chaperone
	Biological Process	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Lipid Transport Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Transport Apoptotic Cell Clearance Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of SMAD Protein Signal Transduction Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Amyloid-beta Clearance Regulation Of Extracellular Matrix Organization Positive Regulation Of Reverse Cholesterol Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Protein Folding G Protein-coupled Receptor Signaling Pathway Sensory Perception Of Smell Regulation Of G Protein-coupled Receptor Signaling Pathway
Pathways		Scavenging of heme from plasma Retinoid metabolism and transport	None
Drugs		Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Von Willebrand factor human Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa	None
GWAS		Abdominal aortic aneurysm ( 22055160 27899403 ) Adult asthma ( 30787307 ) Appendicular lean mass ( 33097823 ) Asthma ( 31959851 31619474 29273806 27182965 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Body mass index ( 28552196 ) Cervical artery dissection ( 25420145 ) Coronary artery disease ( 29212778 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) HDL cholesterol ( 20686565 24097068 ) HDL cholesterol levels ( 28334899 ) Headache ( 29397368 ) Height ( 31562340 ) Itch intensity from mosquito bite ( 28199695 ) Lung function (FEV1/FVC) ( 30804560 ) Medication use (anilides) ( 31015401 ) Medication use (antimigraine preparations) ( 31015401 ) Migraine ( 27322543 22683712 21666692 23793025 27182965 ) Migraine - clinic-based ( 23793025 ) Migraine without aura ( 23793025 27322543 ) Moyamoya disease ( 29273593 ) Peak expiratory flow ( 30804560 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Pulse pressure ( 30578418 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 ) Spontaneous coronary artery dissection ( 32374345 32887874 ) Triglyceride levels ( 28334899 ) Triglycerides ( 25961943 24097068 20686565 )	Adiponectin levels ( 31178129 ) Appendicular lean mass ( 33097823 ) Brain morphology (MOSTest) ( 32665545 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Night sleep phenotypes ( 27126917 ) PR interval ( 32439900 ) Serum alkaline phosphatase levels ( 33547301 33339817 ) Severe influenza A (H1N1) infection ( 26379185 ) Social autistic-like traits ( 24133439 ) Triglyceride levels ( 32154731 32203549 29083408 28334899 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		74 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CLU CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90AA1 HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RBM11 RIC8B RNF10 SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	4 interacting genes: GNAQ GNAS KLHDC2 LRP1
Entrez ID		4035	55188
HPRD ID		00138	16452
Ensembl ID		ENSG00000123384	ENSG00000111785
Uniprot IDs		Q07954 Q59FG2	B7WPL0 Q9NVN3
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	Not available
GO Terms Enriched among Interactors		Signaling Receptor Binding Extracellular Space Extracellular Region Low-density Lipoprotein Particle Receptor Binding Endoplasmic Reticulum Lumen Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Endocytosis Regulation Of Multicellular Organismal Process Extracellular Matrix Heparin Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Golgi Lumen Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Protein Processing Regulation Of Protein Metabolic Process Cell Projection Morphogenesis Positive Regulation Of Protein Metabolic Process Regulation Of Protein Maturation Cell Surface Platelet Alpha Granule Lumen Regulation Of MAPK Cascade Negative Regulation Of Multicellular Organismal Process Regulation Of Proteolysis Nerve Growth Factor Receptor Binding Regulation Of Vesicle-mediated Transport Neuron Projection Morphogenesis Signal Transduction Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Receptor-mediated Endocytosis Modulation Of Chemical Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Amyloid-beta Binding Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Positive Regulation Of Multicellular Organismal Process Perinuclear Region Of Cytoplasm Negative Regulation Of Programmed Cell Death Regulation Of Transport Positive Regulation Of MAPK Cascade	Response To Acidic PH Cellular Response To Acidic PH Guanyl Nucleotide Binding Cellular Response To PH G-protein Beta/gamma-subunit Complex Binding Response To Prostaglandin E Heterotrimeric G-protein Complex Response To PH G Protein Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Mu-type Opioid Receptor Binding Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Lipoprotein Particle Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Hair Follicle Placode Formation Corticotropin-releasing Hormone Receptor 1 Binding Adenylate Cyclase Activator Activity Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Adenylate Cyclase Regulator Activity Positive Regulation Of Lysosomal Protein Catabolic Process Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Nuclear Membrane Response To Alcohol D1 Dopamine Receptor Binding Beta-2 Adrenergic Receptor Binding Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Lamellar Body Regulation Of Body Fluid Levels Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Regulation Of Wnt Signaling Pathway GTPase Activity Cellular Response To Glucagon Stimulus Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Regulation Of Endocytosis Regulation Of Lysosomal Protein Catabolic Process