LMX1A and TCF3

Number of citations: 37 (PubMedID 9199284)
Data Source: BioGRID (two hybrid, pull down)

		LMX1A	TCF3
Name		LIM homeobox transcription factor 1 alpha	transcription factor 3
Structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Vitamin D Response Element Binding E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of Cell Growth Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Axon Guidance Central Nervous System Development Memory Locomotory Behavior Regulation Of Gene Expression Dentate Gyrus Development Cerebellum Development Hippocampus Development Central Nervous System Neuron Differentiation Neuron Differentiation Midbrain Development Olfactory Behavior Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation B Cell Differentiation Positive Regulation Of B Cell Proliferation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		None	Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Diseases		None	Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Age-related hearing impairment ( 34108613 ) Alcohol consumption (drinks per week) ( 30679032 ) Diffusing capacity of the lung for carbon monoxide traits ( 30049742 ) Hip circumference adjusted for BMI ( 34021172 ) Macular thickness ( 30535121 ) Pursuit maintenance gain ( 29064472 ) Response to acetaminophen (hepatotoxicity) ( 21177773 ) Response to methotrexate in juvenile idiopathic arthritis ( 24709693 ) Vestibular neuritis ( 30079052 )	Hodgkin's lymphoma ( 24920014 29196614 ) Monocyte count ( 32888494 ) Objective response to lithium treatment ( 26503763 ) Triglyceride levels ( 34074324 )
Interacting Genes		5 interacting genes: BMPR2 ISL1 LDB1 LHX3 TCF3	66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1
Entrez ID		4009	6929
HPRD ID		02623	00918
Ensembl ID		ENSG00000162761	ENSG00000071564
Uniprot IDs		Q8TE12	P15923
PDB IDs		8IK5 8IKE 8ILW	2MH0 2YPA 2YPB 3U5V 6MGN
GO Terms Enriched among Interactors		RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transcription Regulator Complex Pattern Specification Process LIM Domain Binding Spinal Cord Motor Neuron Cell Fate Specification Positive Regulation Of Transcription By RNA Polymerase II Central Nervous System Neuron Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Atrial Septum Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Positive Regulation Of RNA Metabolic Process Outflow Tract Septum Morphogenesis Positive Regulation Of Nucleobase-containing Compound Metabolic Process BHLH Transcription Factor Binding Neuron Fate Specification Pituitary Gland Development Transcription Cis-regulatory Region Binding Regionalization Cell Differentiation Cell Differentiation In Spinal Cord Regulation Of Transcription By RNA Polymerase II System Development Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Positive Regulation Of Biosynthetic Process Neuron Differentiation Outflow Tract Morphogenesis Cellular Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cardiac Septum Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Fate Specification Cis-regulatory Region Sequence-specific DNA Binding Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Lung Development Stem Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis RNA Polymerase II Transcription Regulator Complex Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Activin Receptor Activity, Type II	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Cell Differentiation Animal Organ Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Developmental Process Animal Organ Morphogenesis Regulation Of Developmental Process Embryonic Morphogenesis