EEIG1 and SKAP1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		EEIG1	SKAP1
Name		estrogen-induced osteoclastogenesis regulator 1	src kinase associated phosphoprotein 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Membrane Membrane Raft	Immunological Synapse Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding
	Biological Process	Positive Regulation Of Osteoclast Differentiation	Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Immune System Process Positive Regulation Of Adaptive Immune Response Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
GWAS		No GWAS studies recorded	Body mass index ( 25673413 28892062 ) Endometrial cancer ( 30093612 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Epithelial ovarian cancer ( 25581431 ) Food allergy ( 29030101 ) Generalized epilepsy ( 22949513 ) HDL cholesterol levels ( 32203549 ) Intelligence ( 28530673 ) Keratoconus ( 33649486 ) Lean body mass ( 28552196 ) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880 ) Ovarian cancer ( 20852632 ) Peanut allergy ( 29030101 ) Pulse pressure ( 30578418 ) White blood cell count ( 32888494 )
Interacting Genes		9 interacting genes: BCAR1 CFTR CYSRT1 ENKD1 NEDD9 PFDN5 SH3GL1 SKAP1 SKAP2	13 interacting genes: APP BLCAP DYNLL2 EEIG1 FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC
Entrez ID		399665	8631
HPRD ID		13262	05396
Ensembl ID		ENSG00000167106	ENSG00000141293
Uniprot IDs		Q5T9C2	Q86WV1 V9HW03
PDB IDs		Not available	1U5D
GO Terms Enriched among Interactors		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Anchoring Junction Immunological Synapse Positive Regulation Of Immunological Synapse Formation Integrin-mediated Signaling Pathway RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly SH3 Domain Binding T Cell Receptor Signaling Pathway	Ephrin Receptor Binding Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Membrane Raft T Cell Costimulation Immune Response-regulating Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune System Process Signaling Receptor Binding Positive Regulation Of Cell Activation Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Signaling Receptor Activator Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of T Cell Activation Regulation Of Immune System Process Phospholipase Activator Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Scaffold Protein Binding Immune System Process Regulation Of Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Cell Activation Regulation Of T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Adhesion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Negative Regulation Of Defense Response Protein Tyrosine Kinase Activity CD8 Receptor Binding Growth Factor Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway