LIPE and KATNA1

Number of citations: 0 (PubMedID 10445032)
Data Source: HPRD (in vitro, in vivo)

		LIPE	KATNA1
Name		lipase E, hormone sensitive type	katanin catalytic subunit A1
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Caveola Membrane	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Katanin Complex Microtubule Cytoskeleton Midbody Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Sterol Ester Esterase Activity Triacylglycerol Lipase Activity Protein Binding Lipase Activity Hydrolase Activity Monoacylglycerol Lipase Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Retinyl-palmitate Esterase Activity Diacylglycerol Lipase Activity	Nucleotide Binding Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Retinol Metabolic Process Diacylglycerol Catabolic Process Ether Lipid Metabolic Process	Cytoplasmic Microtubule Organization Microtubule Severing Cell Division
Pathways		Triglyceride catabolism MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	None
GWAS		No GWAS studies recorded	Brain morphology (MOSTest) ( 32665545 ) Lung cancer ( 27393504 ) Subcortical volume (MOSTest) ( 32665545 ) Testicular germ cell tumor ( 28604728 )
Interacting Genes		11 interacting genes: FABP4 KATNA1 MAPK1 MAPK3 MTNR1A NSFL1C PLIN1 PLIN5 PRKACA STAR TSGA10IP	11 interacting genes: APP CAMSAP3 CLK1 CLU DCAF1 DYNC1H1 DYRK2 KATNB1 LIPE OGT PAFAH1B1
Entrez ID		3991	11104
HPRD ID		01062	05986
Ensembl ID		ENSG00000079435	ENSG00000186625
Uniprot IDs		A8K8W7 Q05469	A8K7S5 O75449
PDB IDs		Not available	5ZQL 5ZQM
GO Terms Enriched among Interactors		Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Biosynthetic Process Regulation Of Golgi Inheritance Interleukin-34-mediated Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Lipid Biosynthetic Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Regulation Of Steroid Biosynthetic Process Bergmann Glial Cell Differentiation Lipid Droplet Cellular Response To Tumor Necrosis Factor Cellular Response To Cold Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Lipid Binding MAP Kinase Activity Regulation Of Golgi Organization Pseudopodium Response To Tumor Necrosis Factor Regulation Of Early Endosome To Late Endosome Transport Schwann Cell Development Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cholesterol Biosynthetic Process Face Development Stress-activated MAPK Cascade ERBB2 Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration Neural Crest Cell Development Lung Morphogenesis Positive Regulation Of Inflammatory Response Positive Regulation Of Cholesterol Metabolic Process Regulation Of Macrophage Chemotaxis Thyroid Gland Development Regulation Of Cholesterol Biosynthetic Process Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Stem Cell Development Regulation Of Stress-activated MAPK Cascade	Positive Regulation Of Nitric Oxide Biosynthetic Process Transport Along Microtubule Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Nitric Oxide Metabolic Process Microtubule-based Movement Regulation Of Microtubule Cytoskeleton Organization Regulation Of Nitric Oxide Biosynthetic Process Cytoskeleton-dependent Intracellular Transport Microtubule-based Transport Regulation Of Nitric Oxide Metabolic Process Cytoplasmic Microtubule Organization Cytoskeleton Axo-dendritic Transport Regulation Of Microtubule-based Process Centrosome Intracellular Signal Transduction Regulation Of Amyloid Fibril Formation Protein Heterodimerization Activity Microtubule Regulation Of Amyloid-beta Clearance Regulation Of Protein Catabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Retrograde Axonal Transport Ether Lipid Metabolic Process Dynein Complex Binding Regulation Of Supramolecular Fiber Organization Protein-containing Complex Growth Cone Microtubule-based Process Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of MiRNA Transcription Nuclear Migration Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Signal Transduction Positive Regulation Of Supramolecular Fiber Organization Microglial Cell Activation Microtubule Cytoskeleton Organization Nucleus Localization Hemopoiesis Leukocyte Activation Involved In Inflammatory Response Negative Regulation Of Signaling Negative Regulation Of Cell Communication Dynein Intermediate Chain Binding Supramolecular Fiber Organization Regulation Of Toll-like Receptor Signaling Pathway Nuclear Estrogen Receptor Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Cytoskeleton Organization