LIG3 and TDP1

Number of citations: 106 (PubMedID 35271311)
Data Source: BioGRID (affinity chromatography technology), HPRD (two hybrid)

		LIG3	TDP1
Name		DNA ligase 3	tyrosyl-DNA phosphodiesterase 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix DNA Ligase III-XRCC1 Complex	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Metal Ion Binding	Double-stranded DNA Binding Single-stranded DNA Binding Nuclease Activity Exonuclease Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity 3'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Mitochondrion Organization V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Metabolic Process Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining	Single Strand Break Repair DNA Repair Double-strand Break Repair DNA Damage Response
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Nonhomologous End-Joining (NHEJ)
Drugs		Bleomycin	None
Diseases		None	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165 ) Electrocardiographic traits (multivariate) ( 32602732 ) Night sleep phenotypes ( 27126917 ) Nonobstructive coronary artery disease ( 26534935 ) Pulse pressure ( 30224653 ) QT interval ( 19305408 24952745 29874175 30679814 ) TPE interval (resting) ( 32386560 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: APP JTB MALAT1 PARP1 TDP1 XRCC1 XRCC5 XRCC6	3 interacting genes: LIG3 TOP1 UBC
Entrez ID		3980	55775
HPRD ID		02966	06226
Ensembl ID		ENSG00000005156	ENSG00000042088
Uniprot IDs		B7Z6I3 P49916	B3KN41 G3V2F4 Q9NUW8
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG 6WH1	1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0 5NW9 5NWA 6DHU 6DIE 6DIH 6DIM 6DJD 6DJE 6DJF 6DJG 6DJH 6DJI 6DJJ 6MJ5 6MYZ 6MZ0 6N0D 6N0N 6N0O 6N0R 6N17 6N19 6W4R 6W7J 6W7K 6W7L 7UFY 7UFZ 8CVQ 8CW2 8UV1 8UZV 8UZZ 8V0B 8V0C 9B3B
GO Terms Enriched among Interactors		Double-strand Break Repair Damaged DNA Binding Telomere Maintenance Telomere Organization DNA End Binding Ku70:Ku80 Complex Protein-DNA Complex Site Of DNA Damage Chromosome, Telomeric Region Regulation Of Base-excision Repair DNA Repair Response To Gamma Radiation Regulation Of Phosphorus Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase Complex DNA Recombination DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex DNA Metabolic Process Positive Regulation Of Phosphate Metabolic Process Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding DNA Damage Response Chromosome Organization Single Strand Break Repair Regulation Of Telomere Maintenance Positive Regulation Of Protein Kinase Activity Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Innate Immune Response Recombinational Repair Response To Ionizing Radiation Cellular Response To Radiation Telomeric DNA Binding Regulation Of Catalytic Activity Cellular Response To Gamma Radiation ATP-dependent Activity, Acting On DNA Innate Immune Response Negative Regulation Of Telomere Maintenance DNA Helicase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Chromosome Regulation Of Chromosome Organization Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Phosphorylation Regulation Of Kinase Activity	Negative Regulation Of Mitochondrial DNA Replication DNA Ligase III-XRCC1 Complex DNA Replication Regulation Of Mitochondrial DNA Replication DNA Ligase (ATP) Activity Lagging Strand Elongation DNA Ligase Activity Dense Fibrillar Component DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Regulation Of Mitochondrial DNA Metabolic Process Cellular Response To Luteinizing Hormone Stimulus Mitochondrial DNA Repair DNA Topoisomerase Activity Response To Luteinizing Hormone Supercoiled DNA Binding Double-strand Break Repair Via Alternative Nonhomologous End Joining Embryonic Cleavage DNA Topological Change Negative Regulation Of DNA-templated DNA Replication Cell Division DNA Strand Elongation Involved In DNA Replication Base-excision Repair, Gap-filling Protein Tag Activity DNA Binding, Bending V(D)J Recombination DNA Strand Elongation Mitochondrial DNA Metabolic Process Cellular Response To Gonadotropin Stimulus DNA Conformation Change RRNA Transcription Negative Regulation Of DNA Replication Response To Gonadotropin DNA Metabolic Process Nuclear Chromosome Base-excision Repair Somatic Cell DNA Recombination Nucleobase-containing Compound Biosynthetic Process Peptidyl-serine Phosphorylation Protein-DNA Complex Male Germ Cell Nucleus Response To Gamma Radiation Animal Organ Regeneration Double-strand Break Repair Via Nonhomologous End Joining Circadian Regulation Of Gene Expression Nucleoplasm Endocytic Vesicle Membrane