LEPR and RNF41

Number of citations: 50 (PubMedID 21378310)
Data Source: BioGRID (protein complementation assay)

		LEPR	RNF41
Name		leptin receptor	ring finger protein 41
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Leptin Metreleptin	None
GWAS		Adult body size ( 32376654 ) Age at voice drop ( 27182965 ) Alanine aminotransferase levels ( 34315874 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Blood protein levels ( 30072576 ) BMI at 1 year old ( 31575865 ) BMI at 1.5 years old ( 31575865 ) BMI at 3 months old ( 31575865 ) BMI at 6 months old ( 31575865 ) BMI at 8 months old ( 31575865 ) BMI at adiposity peak ( 31840077 ) Body size at age 10 ( 32376654 ) C-reactive protein ( 23844046 18439548 22939635 19567438 ) C-reactive protein levels ( 33339817 21300955 29878111 30388399 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Eosinophil percentage of white cells ( 32888494 ) Fasting plasma glucose (childhood) ( 25223902 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Hemoglobin ( 32888494 ) Hip circumference ( 28552196 ) Iron status biomarkers (iron levels) ( 33536631 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Menarche (age at onset) ( 25231870 ) Metabolic traits ( 19060910 ) Molybdenum levels ( 26025379 ) Monocyte percentage of white cells ( 32888494 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Nonalcoholic steatohepatitis ( 32298765 ) Obesity (early onset extreme) ( 23563609 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Soluble leptin receptor levels ( 20167575 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 27863252 )	Asthma ( 31619474 ) Height ( 34054925 )
Interacting Genes		17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1	39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70
Entrez ID		3953	10193
HPRD ID		03001	11520
Ensembl ID		ENSG00000116678	ENSG00000181852
Uniprot IDs		P48357 Q4G138	F8VSB6 Q9H4P4
PDB IDs		3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85	2FZP 2GWF
GO Terms Enriched among Interactors		Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus	Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination