LALBA and B4GALT1

Number of citations: 0 (PubMedID 11947697)
Data Source: HPRD (in vitro)

		LALBA	B4GALT1
Name		lactalbumin alpha	beta-1,4-galactosyltransferase 1
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Golgi Lumen Protein-containing Complex	Golgi Trans Cisterna Golgi Membrane Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Desmosome Filopodium Secretory Granule Membrane Brush Border Membrane Golgi Cisterna Membrane Protein-containing Complex Azurophil Granule Membrane Cell Projection Extracellular Exosome
	Molecular Function	Lysozyme Activity Lactose Synthase Activity Calcium Ion Binding Metal Ion Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity N-acetyllactosamine Synthase Activity Lactose Synthase Activity Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity Manganese Ion Binding UDP-galactosyltransferase Activity Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Lactose Biosynthetic Process Apoptotic Process Signal Transduction Cell-cell Signaling Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Epithelial Cell Development Acute Inflammatory Response Carbohydrate Metabolic Process Lactose Biosynthetic Process Galactose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation Lipid Metabolic Process Cell Adhesion Binding Of Sperm To Zona Pellucida Penetration Of Zona Pellucida Cell Population Proliferation Glycoprotein Biosynthetic Process Oligosaccharide Biosynthetic Process Extracellular Matrix Organization Wound Healing Positive Regulation Of Apoptotic Process Development Of Secondary Sexual Characteristics Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Regulation Of Acrosome Reaction Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Angiogenesis Involved In Wound Healing Positive Regulation Of Circulating Fibrinogen Levels Macrophage Migration
Pathways		Lactose synthesis Developmental Lineage of Mammary Gland Alveolar Cells	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Interaction With Cumulus Cells And The Zona Pellucida Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective B4GALT1 causes CDG-2d Lactose synthesis Neutrophil degranulation N-Glycan antennae elongation
Drugs		Palmitic Acid	N-Acetylglucosamine 6-Aminohexyl-uridine-C1,5'-diphosphate 4)-N-acetyl-beta-D-glucosamine Galactose-uridine-5'-diphosphate Uridine monophosphate 2-(N-morpholino)ethanesulfonic acid
Diseases		None	Congenital disorders of glycosylation (CDG) type II
GWAS		Adiponectin levels ( 24105470 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 )	Aspartate aminotransferase levels ( 33547301 33339817 29403010 ) Blood protein levels ( 30072576 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) IgG fucosylation phenotypes (multivariate analysis) ( 28878392 ) IgG galactosylation phenotypes (multivariate analysis) ( 28878392 ) IgG glycosylation ( 23382691 ) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392 32128391 ) Influenza A (H1N1) infection ( 26379185 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Mild influenza (H1N1) infection ( 26379185 ) N-glycan levels ( 31163085 ) Red blood cell count ( 32888494 ) Serum uric acid levels ( 30993211 ) Severe influenza A (H1N1) infection ( 26379185 ) Urate levels ( 31578528 31985003 23263486 )
Interacting Genes		6 interacting genes: B4GALT1 CRYAA CRYAB H2BC21 H3C15 HSPA8	9 interacting genes: CDK11A EGFR LALBA OR10G4 SNCA TFRC TUBA1A TUBA4A TUBB
Entrez ID		3906	2683
HPRD ID		01024	00659
Ensembl ID		ENSG00000167531	ENSG00000086062
Uniprot IDs		A0A080YV01 P00709	B7ZAH9 P15291 Q86XA6 W6MEN3
PDB IDs		1A4V 1B9O 1CB3 1HML 3B0I 3B0O 4L41	2AE7 2AEC 2AES 2AGD 2AH9 2FY7 2FYA 2FYB 3EE5 4EE3 4EE4 4EE5 4EEA 4EEG 4EEM 4EEO 4L41 6FWT 6FWU
GO Terms Enriched among Interactors		Protein Refolding Tubulin Complex Assembly Unfolded Protein Binding Protein-containing Complex Organization Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Protein Folding Apoptotic Process Involved In Development Lens Development In Camera-type Eye Extracellular Exosome Negative Regulation Of Intracellular Transport Regulation Of Protein Stability Response To Heat Camera-type Eye Development Protein-containing Complex Assembly Positive Regulation Of Circulating Fibrinogen Levels Chaperone-mediated Autophagy Translocation Complex Disassembly Structural Constituent Of Chromatin Response To Hydrogen Peroxide Lactose Biosynthetic Process Lumenal Side Of Lysosomal Membrane Nucleosome Nucleosome Assembly Eye Development Response To Stress Negative Regulation Of Protein-containing Complex Assembly UDP-galactosyltransferase Activity Lactose Synthase Activity Regulation Of Protein Import Nucleosome Organization Response To Temperature Stimulus Response To Reactive Oxygen Species Negative Regulation Of Supramolecular Fiber Organization N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Sensory Organ Development Structural Molecule Activity Protein-containing Complex C3HC4-type RING Finger Domain Binding Clathrin Coat Disassembly Protein-DNA Complex Assembly Development Of Secondary Sexual Characteristics ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Lens Fiber Cell Morphogenesis Cardiac Myofibril Galactosyltransferase Activity Chaperone-mediated Autophagy Protein Stabilization	Mitotic Cell Cycle Structural Constituent Of Cytoskeleton Extracellular Region Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Clathrin-coated Endocytic Vesicle Membrane Positive Regulation Of Protein Localization To Cell Periphery Response To Lipid Protein-containing Complex Virus Receptor Activity Negative Regulation Of Apoptotic Process Shc-EGFR Complex Extracellular Space Multivesicular Body, Internal Vesicle Lumen Lactose Biosynthetic Process CCR7 Chemokine Receptor Binding CCL19-activated CCR7 Signaling Pathway Positive Regulation Of Dendritic Cell Dendrite Assembly Response To Desipramine Response To Iron Ion Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Response To Copper Ion Response To Metal Ion Regulation Of Synapse Organization Phospholipase D Inhibitor Activity Regulation Of Norepinephrine Uptake Positive Regulation Of SNARE Complex Assembly Receptor Internalization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Hsp70 Protein Binding Transferrin Receptor Activity Protein-containing Complex Binding Microtubule Microtubule Cytoskeleton GTP Binding Cytoplasmic Ribonucleoprotein Granule Apoptotic Process Negative Regulation Of Programmed Cell Death Nucleotide Binding Enzyme Binding Regulation Of Cell Growth Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Cell Death Programmed Cell Death Lactose Synthase Activity