KRAS and DNAJA3

Number of citations: 103 (PubMedID 34373451)
Data Source: BioGRID (genetic interference, two hybrid)

		KRAS	DNAJA3
Name		KRAS proto-oncogene, GTPase	DnaJ heat shock protein family (Hsp40) member A3
Structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Neuromuscular Junction Mitochondrial Nucleoid Synapse Postsynaptic Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GMP Binding GDP Binding LRR Domain Binding Identical Protein Binding Protein-membrane Adaptor Activity Protein-containing Complex Binding	Signaling Receptor Binding Type II Interferon Receptor Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Hsp70 Protein Binding GTPase Regulator Activity Heat Shock Protein Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding IkappaB Kinase Complex Binding DNA-binding Transcription Factor Binding
	Biological Process	MAPK Cascade Liver Development Signal Transduction Ras Protein Signal Transduction Female Pregnancy Cell Population Proliferation Visual Learning Response To Gravity Gene Expression Positive Regulation Of Gene Expression Glial Cell Proliferation Rac Protein Signal Transduction Cytokine-mediated Signaling Pathway Forebrain Astrocyte Development Actin Cytoskeleton Organization Negative Regulation Of Epithelial Cell Differentiation Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Response To Isolation Stress Skeletal Muscle Cell Differentiation Negative Regulation Of Neuron Apoptotic Process Regulation Of Long-term Neuronal Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Neuron Apoptotic Process Myoblast Proliferation Cardiac Muscle Cell Proliferation Positive Regulation Of Glial Cell Proliferation Epithelial Tube Branching Involved In Lung Morphogenesis Type I Pneumocyte Differentiation Positive Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Immune System Process Mitochondrial DNA Replication Protein Folding Apoptotic Process Activation-induced Cell Death Of T Cells Response To Stress Mitochondrion Organization Small GTPase-mediated Signal Transduction Neuromuscular Junction Development Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Protein Ubiquitination T Cell Differentiation In Thymus Response To Type II Interferon Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Stabilization Negative Regulation Of Type II Interferon-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Senescence
Pathways		Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX3 regulates p14-ARF RAS processing Signaling downstream of RAS mutants Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Signaling by RAS GAP mutants Signaling by RAS GTPase mutants	None
Drugs		[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Adagrasib Sotorasib	None
Diseases		Acute myeloid leukemia (AML) Oral cancer Non-small cell lung cancer Multiple myeloma Cervical cancer Kaposi's sarcoma Cholangiocarcinoma Gallbladder cancer Gastric cancer Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Ovarian cancer Hepatocellular carcinoma Thyroid cancer Squamous cell carcinoma Colorectal cancer Endometrial Cancer Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome Pancreatic cancer	None
GWAS		Alanine aminotransferase levels ( 33547301 ) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Dysmenorrheic pain ( 27454463 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 )	Erectile dysfunction ( 30583798 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Schizophrenia ( 28991256 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )
Interacting Genes		63 interacting genes: ADH6 ARL6IP5 BCAS3 BCL2 CALM1 CCL5 CCT7 CDK8 DDX47 DDX50 DIRAS3 DNAJA3 EGLN1 EPB42 FANCC FNTA FNTB FRAT2 HEMGN HNRNPC HRAS IGFBP3 IGSF21 IL24 LPAR1 LYPD4 LZTR1 MDFI MOCS2 MT-CO3 MT-CYB NDUFA13 NEDD4 OSGIN1 PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PIP5K1A PPP2CB PSMA3 QDPR RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 RNF141 SERPINB5 SHOC2 SOX4 STX17 THRSP TNFSF13 UQCRC1 WDR76 ZDHHC17 ZNF189	47 interacting genes: ATOSB ATXN1 BRCA1 CACNA1C CARM1 CATSPERT CIDEB COIL CYSRT1 FAM131C FBXO7 FOSL2 FRMD6 FXR1 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS LAMTOR5 MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 PTEN RAD51 RASA1 RELA RNF34 SHANK3 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22
Entrez ID		3845	9093
HPRD ID		01817	09758
Ensembl ID		ENSG00000133703	ENSG00000103423
Uniprot IDs		I1SRC5 L7RSL8 P01116	B3KM81 Q53G26 Q59E88 Q96EY1
PDB IDs		1D8D 1D8E 1KZO 1KZP 1N4P 1N4Q 1N4R 1N4S 2MSC 2MSD 2MSE 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY 4L8G 4LDJ 4LPK 4LRW 4LUC 4LV6 4LYF 4LYH 4LYJ 4M1O 4M1S 4M1T 4M1W 4M1Y 4M21 4M22 4NMM 4OBE 4PZY 4PZZ 4Q01 4Q02 4Q03 4QL3 4TQ9 4TQA 4WA7 5F2E 5KYK 5MLA 5MLB 5O2S 5O2T 5OCG 5OCO 5OCT 5TAR 5TB5 5UFE 5UFQ 5UK9 5UQW 5US4 5USJ 5V6S 5V6V 5V71 5V9L 5V9O 5V9U 5VBM 5VP7 5VPI 5VPY 5VPZ 5VQ0 5VQ1 5VQ2 5VQ6 5VQ8 5W22 5WHA 5WHB 5WHD 5WHE 5WLB 5WPM 5XCO 5YXZ 5YY1 6ARK 6ASA 6ASE 6B0V 6B0Y 6BOF 6BP1 6CC9 6CCH 6CCX 6CU6 6E6F 6E6G 6EPL 6EPM 6EPN 6EPO 6EPP 6F76 6FA1 6FA2 6FA3 6FA4 6GJ5 6GJ6 6GJ7 6GJ8 6GOD 6GOE 6GOF 6GOG 6GOM 6GQT 6GQW 6GQX 6GQY 6H46 6H47 6JTN 6JTO 6JTP 6M9W 6MBQ 6MBT 6MBU 6MNX 6MQG 6MQN 6MS9 6MTA 6N2J 6N2K 6O36 6O46 6O4Y 6O4Z 6O51 6O53 6OB2 6OB3 6OIM 6P0Z 6P8W 6P8X 6P8Y 6P8Z 6PGO 6PGP 6PQ3 6PTS 6PTW 6QUU 6QUV 6QUW 6QUX 6T5B 6T5U 6T5V 6TAM 6TAN 6USX 6USZ 6UT0 6V5L 6V65 6V6F 6VC8 6VJJ 6W4E 6W4F 6WGN 6WS2 6WS4 6XGU 6XGV 6XHA 6XHB 6YR8 6YXW 6ZL5 6ZLI 7A1W 7A1X 7A1Y 7A47 7ACA 7ACF 7ACH 7ACQ 7C40 7C41 7EW9 7EWA 7EWB 7EYX 7F0W 7KFZ 7KMR 7KYZ 7LC1 7LC2 7LGI 7LZ5 7MDP 7MQU 7NY8 7O70 7OK3 7OK4 7OO7 7Q9U 7R0M 7R0N 7R0Q 7ROV 7RP2 7RP3 7RP4 7RPZ 7RSC 7RSE 7RT1 7RT2 7RT3 7RT4 7RT5 7SCW 7SCX 7STF 7T1F 7T47 7TLE 7TLG 7TLK 7U8H 7VVB 7W5R 7YCC 7YCE 7YUZ 7YV1 8AFB 8AFC 8AFD 8AQ5 8AQ7 8AZR 8AZV 8AZX 8AZY 8AZZ 8B00 8B69 8B6I 8B78 8BE3 8BE4 8BE5 8BLR 8CPR 8CX5 8DGS 8DGT 8DNI 8DNJ 8DNK 8DVG 8EBZ 8ECR 8EDY 8EER 8EIE 8EPW 8EZG 8F0M 8FMI 8FMJ 8FMK 8G42 8G47 8G4F 8G4H 8G9P 8G9Q 8I5C 8I5D 8I5E 8JGD 8JHL 8JJS 8K4T 8K4V 8K50 8ONV 8PI0 8PIY 8QU8 8QUG 8QVU 8QW6 8QW7 8R7W 8R7X 8RNI 8RRO 8S8C 8STM 8STN 8T4V 8T71 8T72 8T73 8T74 8T75 8TBF 8TBH 8TBJ 8TBK 8TBL 8TBM 8TBN 8TVK 8TXE 8TXG 8TXH 8TXJ 8TXK 8TY2 8TY8 8TY9 8UDR 8UN3 8UN4 8UN5 8V39 8V3A 8VGQ 8VJZ 8VR9 8VRA 8VRB 8WTE 8WUL 8X6R 8YIV 8YJ2 9AX6 9BFW 9BFY 9BFZ 9BG1 9BHO 9BHP 9BHQ 9BI1 9BI2 9C15 9E5D 9E5F 9E9H 9E9I 9KPM 9KPN	2CTT 2DN9 6IWS 7X89
GO Terms Enriched among Interactors		Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Prenyltransferase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of MAPK Cascade Protein Prenylation Phosphatidylinositol 3-kinase Complex, Class IA GTPase Regulator Activity Prenyltransferase Activity Acetyltransferase Activator Activity Channel Inhibitor Activity Regulation Of Cell Communication Regulation Of Signaling CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Ras Protein Signal Transduction Signal Transduction Protein Farnesylation Positive Regulation Of Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Programmed Cell Death Protein Geranylgeranyltransferase Activity Phosphatidylinositol 3-kinase Complex, Class IB Cytoplasm Glial Cell Development Adenylate Cyclase Activator Activity Quinol-cytochrome-c Reductase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Apoptotic Process Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Programmed Cell Death Protein Geranylgeranylation Insulin Receptor Signaling Pathway Autophagosome Membrane Docking 1-phosphatidylinositol-4-phosphate 3-kinase Activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Intracellular Glucose Homeostasis Neuromuscular Junction Development Apoptotic Process Phosphatidylinositol 3-kinase Complex Negative Regulation Of Fibroblast Apoptotic Process Protein Phosphatase Binding	Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Regulation Of Cell Development Regulation Of Cell Differentiation Nucleoplasm Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Histone H3R2 Methyltransferase Activity Positive Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Histone Arginine N-methyltransferase Activity Regulation Of Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neurogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process