ARF6 and ASAP2

Number of citations: 65 (PubMedID 10749932)
Data Source: HPRD (in vivo)

		ARF6	ASAP2
Name		ARF GTPase 6	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Structure			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Membrane Endocytic Vesicle Midbody Filopodium Membrane Early Endosome Membrane Cleavage Furrow Cell Projection Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Flemming Body Presynapse Postsynapse Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Golgi Cisterna Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Thioesterase Binding Signaling Adaptor Activity	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Liver Development Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Cell Adhesion Nervous System Development Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Cell Differentiation Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Endocytic Recycling Protein Localization To Cell Surface Regulation Of Rac Protein Signal Transduction Protein Localization To Endosome Negative Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Protein Secretion Cell Division Regulation Of Filopodium Assembly Positive Regulation Of Keratinocyte Migration Regulation Of Dendritic Spine Development Cellular Response To Diacyl Bacterial Lipopeptide Protein Localization To Plasma Membrane Establishment Of Epithelial Cell Polarity Ruffle Assembly Hepatocyte Apoptotic Process Maintenance Of Postsynaptic Density Structure Positive Regulation Of Focal Adhesion Disassembly Erythrocyte Apoptotic Process Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Mitotic Cytokinetic Process Protein Localization To Cleavage Furrow Regulation Of Presynapse Assembly Cellular Response To Nerve Growth Factor Stimulus Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Dendrite Development	None
Pathways		TBC/RABGAPs Clathrin-mediated endocytosis MET receptor recycling	None
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Diphosphate Myristic acid	None
GWAS		Erythema nodosum in inflammatory bowel disease ( 24487271 ) Ferritin levels ( 33491795 )	Bipolar disorder ( 31043756 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease ( 30804561 ) Chronic widespread musculoskeletal pain ( 33331911 ) Pulse pressure ( 27841878 30578418 ) Urate levels ( 31578528 )
Interacting Genes		40 interacting genes: AGAP1 AP1B1 AP2B1 AP3B1 AP3D1 AP3S2 APP ARFIP2 ARHGAP10 ARRB1 ARRB2 ASAP1 ASAP2 ASAP3 ATP6V0C CAPN1 CHRM3 CLTC CYTH1 CYTH2 EXOC5 EZR FILNC1 HTR2A IKBKG ITSN1 MEOX2 MT2A PALS1 PIP5K1A PIP5K1C PLD1 RAB11A RAB11FIP3 RAB11FIP4 RAB11FIP5 SMAP1 SNCA SPAG9 ZNF709	14 interacting genes: APC ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A
Entrez ID		382	8853
HPRD ID		02714	04820
Ensembl ID		ENSG00000165527	ENSG00000151693
Uniprot IDs		P62330	O43150
PDB IDs		1E0S 2A5D 2A5F 2A5G 2BAO 2BAU 2J5X 2W83 3LVQ 3LVR 3N5C 3PCR 4FME 4KAX 6BBP 6BBQ 6PAU 7RK3 7XRD	Not available
GO Terms Enriched among Interactors		Vesicle-mediated Transport Cytoplasmic Vesicle Intracellular Protein Localization Membrane Coat Establishment Of Localization In Cell Trans-Golgi Network Membrane Receptor-mediated Endocytosis Endocytosis Receptor Internalization Clathrin-coated Pit Protein Transport Melanosome Assembly Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Cellular Localization Cytoplasmic Vesicle Membrane Organelle Localization Establishment Of Vesicle Localization Platelet Dense Granule Organization Import Into Cell Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Golgi Membrane Establishment Of Protein Localization Vesicle Localization Clathrin-dependent Endocytosis Cellular Component Assembly Endocytic Vesicle Membrane Synaptic Vesicle Transport Melanosome Organization AP-3 Adaptor Complex Pigment Granule Organization Synaptic Vesicle Endocytosis Clathrin Adaptor Complex Positive Regulation Of Endocytosis GTPase Activator Activity Presynaptic Endocytosis Plasma Membrane Lysosomal Membrane Angiotensin Receptor Binding Golgi Apparatus Establishment Of Organelle Localization Secretion Post-Golgi Vesicle-mediated Transport Secretion By Cell Localization Within Membrane Intracellular Transport Regulation Of Cellular Component Organization Protein Localization To Plasma Membrane Anterograde Synaptic Vesicle Transport Focal Adhesion	Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Endocytosis Positive Regulation Of Actin Filament Polymerization Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Cytoskeleton Organization Import Into Cell Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Filament-based Process Cytoskeleton Organization Positive Regulation Of Protein Polymerization Plasma Membrane Positive Regulation Of Cellular Component Biogenesis Regulation Of Actin Filament Polymerization Synaptic Vesicle Endocytosis Regulation Of Endocytosis Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Presynaptic Endocytosis Cytosol Cell Cortex Lamellipodium Positive Regulation Of Cellular Component Organization Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Organization Intracellular Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytoplasm ERBB Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Apical Dendrite Negative Regulation Of Monoatomic Ion Transport GTPase Activity Cellular Localization Establishment Of Localization In Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Transport Actin Cytoskeleton Organization Recycling Endosome GTP Binding