KCNQ3 and KCNQ5

Number of citations: 0 (PubMedID 12890507)
Data Source: HPRD (in vivo)

		KCNQ3	KCNQ5
Name		potassium voltage-gated channel subfamily Q member 3	potassium voltage-gated channel subfamily Q member 5
Structure
GO Annotations	Cellular Component	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Node Of Ranvier Monoatomic Ion Channel Complex Axon Initial Segment Synapse	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Clathrin Coat Monoatomic Ion Channel Complex Presynaptic Membrane Calyx Of Held
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Calmodulin Binding Voltage-gated Monoatomic Cation Channel Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Protein Targeting Protein Import Into Nucleus Monoatomic Ion Transport Potassium Ion Transport Exocytosis Endocytosis Chemical Synaptic Transmission Sensory Perception Of Sound Response To Mechanical Stimulus Gene Expression Response To Auditory Stimulus Protein Transport Neuron Remodeling Neuronal Action Potential Nerve Development Neuron Differentiation Monoatomic Ion Transmembrane Transport Psychomotor Behavior Regulation Of Synaptic Plasticity Neuron Apoptotic Process Establishment Of Localization In Cell Mitochondrial Depolarization Transmembrane Transport Membrane Hyperpolarization Protein-containing Complex Assembly Cellular Response To Calcium Ion Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Apoptosome Assembly Excitatory Chemical Synaptic Transmission Inhibitory Chemical Synaptic Transmission Action Potential Initiation Regulation Of Action Potential Firing Threshold Substantia Propria Of Cornea Development	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential
Pathways		Voltage gated Potassium channels Interaction between L1 and Ankyrins	Voltage gated Potassium channels
Drugs		Enflurane Amitriptyline Meclofenamic acid Gabapentin Promethazine Miconazole Ezogabine ICA-105665	Enflurane Gabapentin Promethazine Miconazole Ezogabine ICA-105665
GWAS		Coronary artery calcification ( 23870195 ) Height ( 28552196 ) LDL peak particle diameter (total fat intake interaction) ( 26112879 ) QT interval ( 29213071 ) Type 2 diabetes ( 31324766 )	Carotid plaque burden ( 28282560 ) Cataracts ( 34127677 ) Frontal pole volume ( 31530798 ) High myopia ( 31816047 ) HIV-1 viral setpoint ( 26039976 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (FVC) ( 30804560 ) Myopia ( 27182965 ) Optic disc size ( 31809533 ) Peak expiratory flow ( 30804560 ) Periodontitis ( 25672891 ) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315 ) Pulse pressure ( 30224653 ) Refractive error ( 23396134 32231278 ) Rosacea symptom severity ( 29771307 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Total body bone mineral density ( 30172743 ) Upper eyelid sagging severity ( 24869959 ) Western dietary pattern ( 28644415 )
Interacting Genes		6 interacting genes: CALM1 CALM2 CALM3 KCNQ2 KCNQ4 KCNQ5	7 interacting genes: CALM1 CALM2 CALM3 DISC1 KCNQ3 MTDH SRC
Entrez ID		3786	56479
HPRD ID		09077	16241
Ensembl ID		ENSG00000184156	ENSG00000185760
Uniprot IDs		E7ET42 O43525	Q9NR82
PDB IDs		5J03	6B8Q
GO Terms Enriched among Interactors		Voltage-gated Potassium Channel Complex Calyx Of Held Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Catalytic Complex Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Transmembrane Transport Calcineurin-mediated Signaling Presynaptic Cytosol Myelin Sheath Response To Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Calcium Channel Regulator Activity Sperm Midpiece Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Potassium Channel Activity Long-term Synaptic Potentiation Sarcomere Cell Cycle G2/M Phase Transition Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Neural Nucleus Development Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity Potassium Channel Activity Calcium-dependent Protein Binding Regulation Of Cardiac Muscle Contraction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity	Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Titin Binding Detection Of Calcium Ion Voltage-gated Potassium Channel Complex Regulation Of Cell Communication By Electrical Coupling Protein Phosphatase Activator Activity Calyx Of Held Regulation Of Heart Rate Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Calcium Channel Complex Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcineurin-mediated Signaling Presynaptic Cytosol Transmembrane Transporter Binding Response To Calcium Ion Myelin Sheath Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Spindle Microtubule Presynaptic Endocytosis Substantia Nigra Development Modulation Of Chemical Synaptic Transmission Calcium Channel Regulator Activity Regulation Of Heart Contraction Sperm Midpiece Regulation Of Synaptic Plasticity Negative Regulation Of Calcium Ion Transport G2/M Transition Of Mitotic Cell Cycle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sarcomere Cell Cycle G2/M Phase Transition Regulation Of Action Potential Neural Nucleus Development Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Detection Of Stimulus Regulation Of Blood Circulation Negative Regulation Of Cation Transmembrane Transport Protein Serine/threonine Kinase Activator Activity Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Voltage-gated Calcium Channel Activity