JUN and EN1

Number of citations: 0 (PubMedID 11551904)
Data Source: HPRD (two hybrid, in vitro)

		JUN	EN1
Name		Jun proto-oncogene, AP-1 transcription factor subunit	engrailed homeobox 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Microglial Cell Activation Liver Development Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway JNK Cascade Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Epithelial Cell Migration Release From Viral Latency Monocyte Differentiation Axon Regeneration Response To Endoplasmic Reticulum Stress Leading Edge Cell Differentiation Response To Muscle Stretch Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Response To Steroid Hormone Regulation Of Cell Cycle SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Anisomycin Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Adult Locomotory Behavior Anatomical Structure Morphogenesis Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Regulation Of Gene Expression Cerebellum Development Central Nervous System Neuron Differentiation Neuron Differentiation Embryonic Limb Morphogenesis Midbrain Development Hindbrain Development Midbrain-hindbrain Boundary Development Embryonic Forelimb Morphogenesis Social Behavior Multicellular Organism Growth Response To Cocaine Drinking Behavior Pigmentation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Limb Development Motor Learning Dopaminergic Neuron Differentiation Embryonic Brain Development
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants Regulation of PD-L1(CD274) transcription	None
Drugs		Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550	None
GWAS		Aspartate aminotransferase levels ( 33547301 ) Cognitive performance ( 19734545 ) Night sleep phenotypes ( 27126917 )	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Blond vs. brown/black hair color ( 30531825 ) Bone mineral density (hip) ( 26733130 ) Bone mineral density (spine) ( 26733130 ) Bone ultrasound measurement (velocity of sound) ( 28472463 ) California verbal learning test score ( 31596458 ) Femoral neck bone mineral density ( 26367794 29499414 ) Heel bone mineral density ( 28869591 30598549 ) Lumbar spine bone mineral density ( 26367794 ) Lung adenocarcinoma ( 28604730 ) Lung function (FVC) ( 30061609 ) Monobrow ( 27182965 ) Mosquito bite size ( 28199695 ) Multiple sclerosis ( 19010793 )
Interacting Genes		181 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GGA1 GGA2 GOPC GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MECOM MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C	3 interacting genes: JUN PAX6 TLE1
Entrez ID		3725	2019
HPRD ID		01302	08835
Ensembl ID		ENSG00000177606	ENSG00000163064
Uniprot IDs		P05412	Q05925
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01 6Y3V 8SOS	Not available
GO Terms Enriched among Interactors		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Regulation Of Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Biosynthetic Process Sequence-specific DNA Binding Transcription By RNA Polymerase II Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Developmental Process Intracellular Signaling Cassette DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process	R-SMAD Binding Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Regulator Complex Response To Anisomycin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Anisomycin Negative Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Gland Development Anatomical Structure Morphogenesis Leading Edge Cell Differentiation Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Response To Wounding Regulation Of Asymmetric Cell Division Habenula Development Oligodendrocyte Cell Fate Specification Pallium Development Release From Viral Latency Ubiquitin Protein Ligase Binding Transcription Factor AP-1 Complex Forebrain Dorsal/ventral Pattern Formation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization Formation Of Anatomical Boundary Glial Cell Fate Specification Regulation Of Epithelial Cell Proliferation Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis Cell Surface Receptor Signaling Pathway Epithelial Cell Differentiation Type B Pancreatic Cell Differentiation Cornea Development In Camera-type Eye Salivary Gland Morphogenesis Host-mediated Suppression Of Viral Transcription Negative Regulation Of Macromolecule Biosynthetic Process Neuron Projection Development Chromatin Binding Negative Regulation Of Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific CAMP Response Element Binding