ITGAX and JAM3

Number of citations: 55 (PubMedID 12208882)
Data Source: HPRD (in vivo)

		ITGAX	JAM3
Name		integrin subunit alpha X	junctional adhesion molecule 3
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Membrane Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion
	Molecular Function	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding	Integrin Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Positive Regulation Of Angiogenesis Defense Response To Virus Cell-cell Adhesion Positive Regulation Of Endothelial Tube Morphogenesis	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Cell-matrix Adhesion Spermatogenesis Spermatid Development Cell Migration Transmission Of Nerve Impulse Establishment Of Cell Polarity Cell Differentiation Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization System Development Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability Positive Regulation Of Monocyte Extravasation
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Cell surface interactions at the vascular wall Integrin cell surface interactions
Drugs		Efalizumab	None
GWAS		IgA nephropathy ( 25305756 ) Post bronchodilator FEV1 ( 26634245 ) Systemic lupus erythematosus ( 18204098 )	Blood protein levels ( 30072576 ) Neutrophil count ( 32888494 )
Interacting Genes		5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3	8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1
Entrez ID		3687	83700
HPRD ID		01051	06042
Ensembl ID		ENSG00000140678	ENSG00000166086
Uniprot IDs		H3BN02 P20702	Q9BX67
PDB IDs		1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Immune System Process Regulation Of Immune System Process Integrin Binding Positive Regulation Of Humoral Immune Response Leukocyte Migration Involved In Inflammatory Response Leukocyte Migration Amyloid-beta Clearance Cargo Receptor Activity Positive Regulation Of Immune Effector Process Cell Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Heterotypic Cell-cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Motility Regulation Of Humoral Immune Response Macrophage Activation Endothelial Cell Migration C5L2 Anaphylatoxin Chemotactic Receptor Binding Low-affinity IgE Receptor Activity Granulocyte Migration Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Leukocyte Activation Cell-matrix Adhesion Positive Regulation Of Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response B Cell Antigen Processing And Presentation Myeloid Leukocyte Activation Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Myeloid Leukocyte Migration Integrin AlphaL-beta2 Complex Leukocyte Chemotaxis Immune System Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Fc Receptor-mediated Immune Complex Endocytosis ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-substrate Adhesion Negative Regulation Of Integrin Activation Regulation Of Cell Adhesion Receptor-mediated Endocytosis	Regulation Of Establishment Of Protein Localization Cell-cell Adhesion Integrin Binding Integrin Complex Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Tight Junction Podosome Regulation Of Myelination Positive Regulation Of Establishment Of Protein Localization Cell Adhesion Tertiary Granule Membrane Regulation Of Protein Localization Cellular Component Maintenance Plasma Membrane Regulation Of Cell Migration Anchoring Junction Proteinase-activated Receptor Activity Integrin AlphaM-beta2 Complex Integrin-mediated Signaling Pathway Regulation Of Cell Motility Integrin AlphaX-beta2 Complex Regulation Of Locomotion Positive Regulation Of Endothelial Tube Morphogenesis Cell-matrix Adhesion Regulation Of Secretion By Cell Thrombin-activated Receptor Activity Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Cell-substrate Adhesion Ectodermal Cell Differentiation Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Regulation Of Nervous System Process Positive Regulation Of Cell Motility Somite Specification Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Bicellular Tight Junction Membrane Curvature Sensor Activity Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion