ITGAD and VCAM1

Number of citations: 0 (PubMedID 10438935)
Data Source: BioGRID (pull down), HPRD (in vitro)

		ITGAD	VCAM1
Name		integrin subunit alpha D	vascular cell adhesion molecule 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane	Podosome Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane Filopodium Sarcolemma Apical Part Of Cell Extracellular Exosome Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex
	Molecular Function	Signaling Receptor Activity Metal Ion Binding	Integrin Binding Primary Methylamine Oxidase Activity Cell Adhesion Molecule Binding Cell Adhesion Mediator Activity
	Biological Process	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion Cell-cell Adhesion	Response To Hypoxia Chronic Inflammatory Response Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Response To Nutrient Amine Metabolic Process Response To Zinc Ion Response To Ionizing Radiation Membrane To Membrane Docking B Cell Differentiation Response To Lipopolysaccharide Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Response To Nicotine Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Response To Ethanol Leukocyte Tethering Or Rolling Cell Chemotaxis Innervation Cardiac Neuron Differentiation Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion Cellular Response To Amyloid-beta
Pathways		Integrin cell surface interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		None	Ethanol Carvedilol Succinobucol Clove oil
GWAS		Glycated hemoglobin levels ( 34059833 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )	Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 21833088 24076602 31604244 ) Neutrophil percentage of white cells ( 32888494 ) Sjögren's syndrome ( 24097067 )
Interacting Genes		4 interacting genes: ICAM3 ITGB2 SHARPIN VCAM1	13 interacting genes: CCL17 CCL22 CTSG ELANE EZR IL13 ITGAD ITGB1 ITGB7 MSN TRIM54 TRIM65 USP2
Entrez ID		3681	7412
HPRD ID		11785	01888
Ensembl ID		ENSG00000156886	ENSG00000162692
Uniprot IDs		Q13349 Q59H14	P19320
PDB IDs		Not available	1IJ9 1VCA 1VSC
GO Terms Enriched among Interactors		Integrin Binding Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Cell-cell Adhesion Phagocytosis Cell-matrix Adhesion Cell Adhesion Molecule Binding Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Cell Adhesion Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Cell-substrate Adhesion Integrin AlphaL-beta2 Complex Peripheral Nervous System Neuron Differentiation ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Chemotaxis Negative Regulation Of Dopamine Metabolic Process LUBAC Complex Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Regulation Of Neutrophil Degranulation Positive Regulation Of Leukocyte Cell-cell Adhesion Primary Methylamine Oxidase Activity Cell-cell Adhesion Mediated By Integrin Apoptotic Nuclear Changes Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway Defense Response Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Chemotaxis Positive Regulation Of Cell-cell Adhesion Chronic Inflammatory Response External Side Of Plasma Membrane Locomotion Complement Component C3b Binding Cell Adhesion Mediator Activity Regulation Of Leukocyte Cell-cell Adhesion Endocytosis Regulation Of Dopamine Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Leukocyte Migration Involved In Inflammatory Response Cellular Extravasation Innervation Leukocyte Tethering Or Rolling	Immune System Process Immune Response Leukocyte Cell-cell Adhesion Leukocyte Migration Cell Adhesion Molecule Binding Integrin Complex Killing Of Cells Of Another Organism Inflammatory Response Heterotypic Cell-cell Adhesion Cell Migration Defense Response Membrane To Membrane Docking Cell Motility Response To Other Organism Cell Killing Defense Response To Symbiont Positive Regulation Of Early Endosome To Late Endosome Transport Defense Response To Other Organism Positive Regulation Of Protein Localization To Early Endosome Neutrophil-mediated Killing Of Bacterium Filopodium Cell-cell Adhesion Positive Regulation Of Protein Localization To Endosome Response To External Biotic Stimulus Uropod Integrin-mediated Signaling Pathway Cell-matrix Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Mononuclear Cell Migration Regulation Of Early Endosome To Late Endosome Transport Extracellular Space Leukocyte Tethering Or Rolling Neutrophil Mediated Immunity Cell Surface Establishment Of Apical/basal Cell Polarity Leukocyte Adhesion To Vascular Endothelial Cell Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Cell Adhesion Mediated By Integrin Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Cell-substrate Adhesion Antimicrobial Humoral Response Killing By Host Of Symbiont Cells Cytokine-mediated Signaling Pathway Focal Adhesion T Cell Migration Biological Process Involved In Interaction With Symbiont