ITGA5 and ARHGAP5

Number of citations: 0 (PubMedID 8537347)
Data Source: HPRD (in vivo)

		ITGA5	ARHGAP5
Name		integrin subunit alpha 5	Rho GTPase activating protein 5
Structure
GO Annotations	Cellular Component	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Cell Junction Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Postsynaptic Membrane Anchoring Junction Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Signaling Receptor Binding Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding Cell Adhesion Molecule Binding	GTPase Activity GTPase Activator Activity Protein Binding SH2 Domain Binding
	Biological Process	Angiogenesis Formation Of Primary Germ Layer Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Tissue Development Positive Regulation Of Cell-substrate Adhesion Response To Muscle Activity CD40 Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Regulation Of Angiogenesis Symbiont Entry Into Host Cell Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Size Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Cell Migration Mammary Gland Development Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration GPER1 signaling Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs		Resveratrol Tauroursodeoxycholic acid	None
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Asthma ( 29273806 )
Interacting Genes		32 interacting genes: ACKR5 ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL VTN	12 interacting genes: ADRB2 CSDE1 FGF13 HSPA13 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND3 SMURF2
Entrez ID		3678	394
HPRD ID		00627	04060
Ensembl ID		ENSG00000161638	ENSG00000100852
Uniprot IDs		B2R627 P08648	Q13017
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4 7NWL 7NXD 9B9J 9B9K 9CKV	2EE4 2EE5 5U4V
GO Terms Enriched among Interactors		Cell Adhesion Integrin Binding Cell-substrate Adhesion Cell-matrix Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Angiogenesis Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Migration Extracellular Matrix Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Receptor Complex Response To Growth Factor Signal Transduction Cell Adhesion Mediated By Integrin Enzyme-linked Receptor Protein Signaling Pathway Cell Motility Extracellular Exosome Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Response To Wounding Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Extracellular Space Negative Regulation Of Blood Coagulation Cell Junction Organization Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Activity Mesodermal Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Extracellular Region Regulation Of Cell-substrate Adhesion Regulation Of Anatomical Structure Morphogenesis Platelet Alpha Granule Membrane Protein Tyrosine Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Wound Healing Regulation Of Cell Population Proliferation	Integrin Alpha5-beta1 Complex Wound Healing, Spreading Of Cells Regulation Of Developmental Process Focal Adhesion Cell-cell Adhesion Mediated By Integrin Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Ruffle Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Angiogenesis Ruffle Cell Differentiation Negative Regulation Of Anoikis Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Signal Transduction Regulation Of Organelle Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Bone Resorption Blood Vessel Diameter Maintenance Regulation Of Tube Size Cell-substrate Adhesion Regulation Of Supramolecular Fiber Organization Neuron Migration Regulation Of Actin Filament-based Process Regulation Of Anoikis Integrin Complex Cell Adhesion Mediated By Integrin LncRNA Binding Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Cerebral Cortex Cell Migration Response To Muscle Activity Positive Regulation Of Excitatory Postsynaptic Potential Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Angiogenesis