ITGA3 and TSPAN4

Number of citations: 0 (PubMedID 9360996)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		ITGA3	TSPAN4
Name		integrin subunit alpha 3	tetraspanin 4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Growth Cone Filopodium Membrane Neuromuscular Junction Integrin Alpha3-beta1 Complex Cell Projection Receptor Complex Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Excitatory Synapse Extracellular Exosome Anchoring Junction Cell Periphery Synaptic Membrane Glutamatergic Synapse Growth Cone Filopodium	Plasma Membrane Focal Adhesion Membrane Vesicle
	Molecular Function	Fibronectin Binding Protease Binding Integrin Binding Protein Binding Collagen Binding Protein Domain Specific Binding Signaling Receptor Activity Laminin Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity	Antigen Binding Integrin Binding Protein Binding
	Biological Process	Neuron Migration System Process Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Rho Protein Signal Transduction Heart Development Memory Response To Xenobiotic Stimulus Regulation Of Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Wnt Signaling Pathway Cell Differentiation Lung Development Regulation Of BMP Signaling Pathway Negative Regulation Of Cell Projection Organization Response To Gonadotropin Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Skin Development Mesodermal Cell Differentiation System Development Leukocyte Migration Maternal Process Involved In Female Pregnancy Nephron Development Dendritic Spine Maintenance Renal Filtration Cell-cell Adhesion Postsynapse Organization Synaptic Membrane Adhesion Positive Regulation Of Protein Localization To Plasma Membrane	Protein-containing Complex Assembly
Pathways		Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions MET activates PTK2 signaling	None
GWAS		No GWAS studies recorded	Falling risk ( 32999390 )
Interacting Genes		16 interacting genes: ADAM9 BIN1 CALR CD151 CD82 CD9 FHL2 FN1 HPS5 HSPD1 ITGB1 LGALS8 LINC00632 RABIF TIMP2 TSPAN4	49 interacting genes: CATSPER1 CD46 CD81 CD9 CHRD CLDN11 CLEC2D CREB3 CREB5 CYSRT1 EVA1A FCHO1 FRS3 GNE GRN GUCD1 HOXA1 ITGA3 ITGA6 ITGB1 KRTAP10-1 KRTAP10-8 KRTAP4-11 KRTAP4-5 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE2B LCE2D LCE3A LCE3C LCE3D LCE4A LRRC25 LTB4R2 MDFI MGAT5B MKRN3 NBPF19 NOTCH2NLA NR4A3 OTX1 PHLDA1 PLSCR4 SGPL1 TEKT4 TMEM106A VGLL3
Entrez ID		3675	7106
HPRD ID		05431	04033
Ensembl ID		ENSG00000005884	ENSG00000214063
Uniprot IDs		A0A140VJM0 P26006	A8MVV6 O14817
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Integrin Binding Focal Adhesion Protease Binding Calcium-independent Cell-matrix Adhesion Cell Surface Cell Activation Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Endothelial Cell Migration Protein-folding Chaperone Binding Positive Regulation Of Cell Migration Cell Migration Leukocyte Activation Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Locomotion Regulation Of Cell Migration Positive Regulation Of Cell Motility Laminin Binding Protein Maturation Extracellular Space Regulation Of Cell Motility Regulation Of Locomotion External Side Of Plasma Membrane Cell Motility Regulation Of Membrane Protein Ectodomain Proteolysis Myoblast Fusion Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Cellular Response To Low-density Lipoprotein Particle Stimulus Cell-substrate Adhesion Response To Muscle Activity Positive Regulation Of Endocytosis Cardiac Muscle Cell Differentiation Cell-cell Fusion Syncytium Formation By Plasma Membrane Fusion Biological Process Involved In Interaction With Symbiont Cellular Response To Lipoprotein Particle Stimulus Syncytium Formation Cell Differentiation Cellular Component Assembly Regulation Of Neuron Differentiation B Cell Activation Positive Regulation Of Transport Lymphocyte Activation Lipid Tube Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Cardiocyte Differentiation Cell Adhesion	Keratinization Epidermis Development Keratin Filament Intermediate Filament Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Myoblast Fusion Involved In Skeletal Muscle Regeneration Myoblast Fusion Integrin Complex Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Lipoprotein Particle Stimulus Cell-cell Fusion Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Cerebellar Climbing Fiber To Purkinje Cell Synapse Identical Protein Binding CAMP Response Element Binding Regulation Of Cell Motility Hair Cycle Regulation Of Locomotion Integrin Binding Mesodermal Cell Differentiation Tissue Development