AR and SPDEF

Number of citations: 0 (PubMedID 10625666)
Data Source: HPRD (in vitro, in vivo)

		AR	SPDEF
Name		androgen receptor	SAM pointed domain containing ETS transcription factor
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Protein-containing Complex	Chromatin Nucleus
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II General Transcription Initiation Factor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Signaling Receptor Binding Steroid Binding Androgen Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Lipid Binding Enzyme Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding ATPase Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding POU Domain Binding Molecular Condensate Scaffold Activity Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade In Utero Embryonic Development Regulation Of Systemic Arterial Blood Pressure Epithelial Cell Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Cell-cell Signaling Spermatogenesis Single Fertilization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Fertilization Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Male Somatic Sex Determination Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Leydig Cell Differentiation Response To Testosterone Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Integrin Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Insulin-like Growth Factor Receptor Signaling Pathway Reproductive Structure Development Regulation Of Developmental Growth Animal Organ Formation Male Genitalia Morphogenesis Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Prostate Induction Morphogenesis Of An Epithelial Fold Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Regulation Of Prostatic Bud Formation Prostate Gland Growth Prostate Gland Epithelium Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Reproductive System Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus Seminiferous Tubule Development Membraneless Organelle Assembly Positive Regulation Of MiRNA Transcription Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Glandular Epithelial Cell Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Negative Regulation Of Cell Fate Commitment Positive Regulation Of Cell Fate Commitment Cell Differentiation Positive Regulation Of Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Lung Goblet Cell Differentiation Intestinal Epithelial Cell Development Epithelial Cell Fate Commitment
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation	None
Drugs		Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Flutamide Oxandrolone Fluphenazine Testosterone Mitotane Estrone Nilutamide Tamoxifen Norethisterone Drostanolone Norgestimate Nandrolone phenpropionate Ketoconazole Acetophenazine Bicalutamide Fluoxymesterone Drospirenone Danazol Testosterone propionate Oxybenzone 1-Testosterone Boldenone Calusterone Periciazine Prasterone Flufenamic acid Stanolone (R)-Bicalutamide Metribolone (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE Cyproterone acetate LGD2941 Dimethylcurcumin Oxymetholone Methyltestosterone Norelgestromin Stanozolol Tetrahydrogestrinone (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide BMS-564929 S-23 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide Andarine (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile LGD-2226 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL Triclosan Nandrolone decanoate Ulipristal Enzalutamide Eugenol Dienogest Norethynodrel Norgestrel Homosalate Enzacamene Luprostiol Mibolerone Phenothiazine Gestrinone Apalutamide Clascoterone Darolutamide Esculin Ligandrol Testosterone cypionate Testosterone enanthate Testosterone undecanoate Stanolone acetate Segesterone acetate Boldenone undecylenate Echinacoside Ketodarolutamide	None
Diseases		Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism Prostate cancer 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)	None
GWAS		Balding ( 26926045 ) Estradiol levels ( 34255042 ) Excessive daytime sleepiness ( 27992416 ) Fasting insulin ( 34059833 ) LDL cholesterol ( 19060910 ) Male-pattern baldness ( 18849991 22032556 22693459 27182965 28196072 29146897 ) Prostate cancer ( 21743467 )	Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Chronic lymphocytic leukemia (time to first treatment) ( 33510140 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 34021172 ) Inflammatory bowel disease ( 27569725 ) Refractive error ( 32231278 ) Weight ( 28552196 )
Interacting Genes		268 interacting genes: ABL1 ABL2 ACTB AHR AKT1 APOL2 APPBP2 ARID5A ATF2 BAG1 BLK BLNK BRCA1 BTK CACUL1 CALM1 CALR CASP1 CASP3 CASP7 CASP8 CAV1 CCAR2 CCND1 CCNE1 CCNH CDC25A CDC25B CDC37 CDK1 CDK6 CDK7 CDK9 CEBPA CEBPB CHD8 COX5B CREBBP CRK CTDSP2 CTNNB1 CUL4B DAP3 DAXX DCAF6 DCC DDB2 DDC DENND5A EED EFCAB6 EGFR ELF3 EP300 ERCC2 ERCC3 ESR1 ETV5 EZH2 FES FGR FHL2 FLNA FOXA1 FOXG1 FOXO1 GADD45GIP1 GAK GAPDH GLI2 GRAP2 GRB2 GRB7 GRIP1 GSK3B GSN GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 HCK HDAC1 HDAC3 HDAC4 HIF1A HIPK3 HMGB1 HMGB2 HOTAIR HSH2D HSP90AA1 IARS1 IDE IFI16 IL6ST INPPL1 JMJD1C JUN KAT2B KAT5 KAT7 KDM1A KIF15 KIF1A KIFAP3 KLK2 LCK LCOR LYN MAGEA11 MAPK1 MATK MDM2 MDN1 MED1 MED12L MED14 MED24 MLH3 MYBBP1A MYLIP NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NDE1 NELFCD NFKB1 NISCH NLRP10 NONO NR0B1 NR0B2 NR2C1 NR2C2 NR3C1 NR3C2 NR5A1 NRIP1 NSD1 NSD2 PA2G4 PAK6 PELP1 PGK1 PIAS1 PIAS2 PIAS3 PIAS4 PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PNRC1 PNRC2 POU2F1 POU2F2 POU5F1 PRKG1 PRMT1 PRPF6 PSMC3IP PTEN PTK6 PTPN11 PXN RAC3 RACK1 RAD54L2 RAD9A RAF1 RAN RANBP9 RASA1 RB1 RBAK RCHY1 REL RELA REPS2 RNASEL RNF14 RNF4 RNF6 RUNX1 RUNX2 SART3 SENP2 SFPQ SH2D1A SH2D1B SH2D2A SH2D3C SH3YL1 SHB SHC1 SHC3 SHC4 SHE SIRT1 SLC25A4 SMAD1 SMAD3 SMAD4 SMARCA2 SMARCA4 SMARCD1 SMARCE1 SNW1 SOCS3 SOCS6 SP1 SPDEF SPOP SRC SREBF1 SRY STAP1 STAT3 STUB1 SUMO1 SUV39H2 SVIL SYK TADA3 TAF1 TBP TCF20 TCF4 TCF7L2 TDG TGFB1I1 TGIF1 TLE5 TMF1 TNK2 TNS1 TNS4 TPD52 TRAF4 TRIM24 TRIP4 TSG101 TXNDC5 UBE2I UBE3A USP10 USP2 UXT VAV1 VAV2 VAV3 VCP WIPI1 XRCC5 XRCC6 YES1 YWHAQ ZBTB1 ZBTB32 ZMIZ1 ZMIZ2 ZNF451	13 interacting genes: AR CDK11A CEP57 COX5A ENKD1 FAM161B NKX3-1 PCGF2 PSMA1 SNX20 SRPK2 STK11 TTC23
Entrez ID		367	25803
HPRD ID		02437	12176
Ensembl ID		ENSG00000169083	ENSG00000124664
Uniprot IDs		A0A087WUX9 F1D8N5 G4VV16 P10275 Q9NUA2	O95238
PDB IDs		1E3G 1GS4 1T5Z 1T63 1T65 1XJ7 1XOW 1XQ3 1Z95 2AM9 2AMA 2AMB 2AO6 2AX6 2AX7 2AX8 2AX9 2AXA 2HVC 2OZ7 2PIO 2PIP 2PIQ 2PIR 2PIT 2PIU 2PIV 2PIW 2PIX 2PKL 2PNU 2Q7I 2Q7J 2Q7K 2Q7L 2YHD 2YLO 2YLP 2YLQ 2Z4J 3B5R 3B65 3B66 3B67 3B68 3BTR 3L3X 3L3Z 3RLJ 3RLL 3V49 3V4A 3ZQT 4HLW 4K7A 4OEA 4OED 4OEY 4OEZ 4OFR 4OFU 4OGH 4OH5 4OH6 4OHA 4OIL 4OIU 4OJ9 4OJB 4OK1 4OKB 4OKT 4OKW 4OKX 4OLM 4QL8 5CJ6 5JJM 5T8E 5T8J 5V8Q 5VO4 7ZTX 7ZTZ 7ZU1 7ZU2 8E1A 8FGY 8FGZ 8FH0 8FH1 8FH2 8RM6 8RM7	1YO5 2DKX
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Phosphotyrosine Residue Binding Chromatin Intracellular Signal Transduction Nuclear Receptor Binding Chromatin Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Enzyme Binding Regulation Of Developmental Process Macromolecule Metabolic Process Transcription Coactivator Activity Cellular Response To Stress Cell Differentiation Cytosol Regulation Of Cell Differentiation Cellular Developmental Process Regulation Of Signal Transduction	Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Epithelial Cell Proliferation Regulation Of Reproductive Process Nuclear Receptor Activity Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Prostate Gland Growth Epithelial Cell Proliferation Involved In Prostate Gland Development Estrogen Response Element Binding Branching Involved In Prostate Gland Morphogenesis Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Nuclear Receptor-mediated Signaling Pathway Male Gonad Development Androgen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Estrogen Receptor Signaling Pathway Gonad Development Negative Regulation Of Epithelial Cell Proliferation Hormone-mediated Signaling Pathway Steroid Binding 14-3-3 Protein Binding Reproductive Structure Development Nuclear Estrogen Receptor Binding Developmental Process Involved In Reproduction Response To Testosterone Regulation Of Apoptotic Process Prostate Induction Regulation Of Programmed Cell Death Organ Growth Transcription Coactivator Binding Intracellular Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Androgen Secretion MADS Box Domain Binding Regulation Of Morphogenesis Of A Branching Structure Cytoplasmic Microtubule Chromatin Response To Estrogen Regulation Of Morphogenesis Of An Epithelium Negative Regulation Of Reproductive Process Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Dorsal Aorta Development Centrosome Regulation Of MiRNA Transcription ATPase Binding Lipid Binding