IRAK1 and IRF4

Number of citations: 55 (PubMedID 21903422)
Data Source: BioGRID (pull down)

		IRAK1	IRF4
Name		interleukin 1 receptor associated kinase 1	interferon regulatory factor 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Surface Endosome Membrane Membrane Protein-containing Complex	Chromatin Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Toll Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cellular Response To Heat Intracellular Signal Transduction Interleukin-33-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Autophosphorylation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell	Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Multicellular Organismal Process T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway p75NTR recruits signalling complexes p75NTR recruits signalling complexes NF-kB is activated and signals survival TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Transcriptional Regulation by MECP2 Interleukin-1 signaling IRAK1 recruits IKK complex SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in pigmentation
Drugs		Fostamatinib	None
GWAS		Celiac disease ( 22057235 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Rheumatoid arthritis ( 23143596 24390342 32723749 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 ) Systemic lupus erythematosus ( 19838195 26502338 26606652 26663301 33272962 )	Age at first sexual intercourse ( 34211149 ) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Alopecia areata ( 25608926 ) Asthma (childhood onset) ( 31036433 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Autoimmune thyroid disease ( 32581359 ) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199 ) Basal cell carcinoma ( 31174203 27539887 ) Black vs. blond hair color ( 18483556 ) Black vs. red hair color ( 18483556 ) Blond vs non-blond hair color ( 26184321 ) Blond vs. brown/black hair color ( 30531825 ) Brown vs. black hair color ( 30531825 ) Brown vs. non-brown hair color ( 26184321 ) Celiac disease ( 22057235 20190752 ) Chronic lymphocytic leukemia ( 28165464 26956414 23770605 24292274 18758461 ) Crohn's disease ( 26192919 ) Cutaneous squamous cell carcinoma ( 27424798 32041948 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Epstein-Barr virus EA-D antibody levels ( 33204752 ) Eye color ( 20585627 30664655 ) Eye color (brightness) ( 30664655 ) Eye color traits ( 30166351 ) Facial pigmentation ( 25705849 ) Feeling nervous ( 29500382 ) Freckles ( 17952075 ) Freckling ( 20585627 ) Hair color ( 30664655 20585627 29662168 23548203 26926045 ) Hair greying ( 26926045 ) Hair morphology traits ( 30166351 ) Hematology traits ( 23303382 ) IgA nephropathy ( 32912934 ) Inflammatory bowel disease ( 26192919 ) Keratinocyte cancer (MTAG) ( 31174203 ) Light vs. dark hair color ( 26184321 ) Limited cutaneous systemic scleroderma ( 29293537 ) Low tan response ( 29739929 ) Lung adenocarcinoma ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Male-pattern baldness ( 27182965 29146897 28196072 ) Medication use (thyroid preparations) ( 31015401 ) Melanoma ( 28212542 ) Membranous nephropathy ( 32231244 ) Monobrow ( 27182965 ) Monocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Nevus count ( 30429480 ) Non-melanoma skin cancer ( 29739929 23548203 ) Progressive supranuclear palsy ( 21685912 ) Psoriasis ( 25903422 23143594 25574825 ) Rheumatoid arthritis ( 30423114 24390342 ) Rosacea symptom severity ( 29771307 ) Skin aging (microtopography measurement) ( 28502801 ) Skin colour saturation ( 25963972 ) Skin pigmentation ( 30664655 ) Skin pigmentation traits ( 30166351 ) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655 ) Squamous cell carcinoma ( 26829030 31174203 ) Sunburns ( 23548203 ) Systemic lupus erythematosus ( 33536424 ) Tanning ( 23548203 ) Type 1 diabetes ( 34012112 34127860 ) Vitiligo ( 27723757 ) White blood cell count ( 32888494 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		52 interacting genes: AKT1 BCL10 BTK CCDC47 FADD H3-4 HRAS HSP90AA1 IKBKG IL1RAP IRAK1BP1 IRAK2 IRAK3 IRAK4 IRF4 IRF7 ITGAM JUN MAP3K7 MAPK14 MAPK8 MBP MYD88 NLRP12 NTRK3 OPTN PELI1 PELI2 PELI3 PPP1CC PPP3CB PRDX1 PRKCI PRKCZ RIPK2 SIGIRR SQSTM1 STAT3 STING1 SUMO1 TAB2 TBKBP1 TICAM2 TIFA TLR2 TLR4 TOLLIP TRAF4 TRAF6 TRIM32 USP20 YTHDC2	22 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 GIPC2 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 TSEN54 USP4 YTHDC2
Entrez ID		3654	3662
HPRD ID		02235	03543
Ensembl ID		ENSG00000184216	ENSG00000137265
Uniprot IDs		D3YTB5 P51617	Q15306
PDB IDs		6BFN	2DLL 6TD4 7JM4 7O56 7OGS 7OOT 7RH2
GO Terms Enriched among Interactors		Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Signaling Pathway Immune System Process Activation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Innate Immune Response-activating Signaling Pathway Defense Response Regulation Of Innate Immune Response Response To External Biotic Stimulus Cell Surface Toll-like Receptor Signaling Pathway Response To Other Organism Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Immune Response Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Toll-like Receptor 4 Signaling Pathway Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Stress Positive Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Immune Response Regulation Of Intracellular Signal Transduction Defense Response To Symbiont Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cytokine Production Signal Transduction Intracellular Signaling Cassette Signaling Adaptor Activity Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Signaling Regulation Of Cell Communication	Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Nucleoplasm Leukocyte Activation Involved In Immune Response B Cell Activation Involved In Immune Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Activation Involved In Immune Response Regulation Of Cell Activation DNA-binding Transcription Factor Activity Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Isotype Switching To IgE Isotypes Isotype Switching Positive Regulation Of B Cell Activation Somatic Diversification Of Immunoglobulins Involved In Immune Response Positive Regulation Of Gene Expression B Cell Activation Regulation Of Macromolecule Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Leukocyte Activation Chromatin Lipopolysaccharide-mediated Signaling Pathway DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Lymphocyte Activation Involved In Immune Response DNA Binding Regulation Of Gene Expression Somatic Diversification Of Immunoglobulins Negative Regulation Of RNA Metabolic Process Somatic Cell DNA Recombination Nucleus Toll Signaling Pathway Macrophage Differentiation Regulation Of B Cell Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Cell Activation Positive Regulation Of Macromolecule Biosynthetic Process Interleukin-33-mediated Signaling Pathway Lymphocyte Activation Regulation Of Metabolic Process Regulation Of Primary Metabolic Process T-helper 2 Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Immune System Process Myeloid Leukocyte Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II