INSM1 and MPP3

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		INSM1	MPP3
Name		INSM transcriptional repressor 1	MAGUK p55 scaffold protein 3
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Repressor Complex	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Cyclin Binding Chromatin DNA Binding Histone Deacetylase Binding Metal Ion Binding Molecular Adaptor Activity	Protein Binding PDZ Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Protein Phosphorylation Type B Pancreatic Cell Differentiation Pancreatic A Cell Differentiation Type B Pancreatic Cell Development Noradrenergic Neuron Development Nervous System Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Cell Cycle Process Cell Migration Cell Differentiation Neuron Differentiation Positive Regulation Of Cell Migration Endocrine Pancreas Development Endocrine System Development Regulation Of Cell Population Proliferation Norepinephrine Biosynthetic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of Cell Cycle Transdifferentiation Adrenal Chromaffin Cell Differentiation Sympathetic Ganglion Development Positive Regulation Of Neural Precursor Cell Proliferation	None
Pathways		Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	None
GWAS		No GWAS studies recorded	HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 )
Interacting Genes		5 interacting genes: CCND1 KDM1A MPP3 SORBS1 TUBB3	37 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1
Entrez ID		3642	4356
HPRD ID		02480	03069
Ensembl ID		ENSG00000173404	ENSG00000161647
Uniprot IDs		Q01101	D3DX46 Q13368
PDB IDs		2LV2 3ZMS 8JPY 8JQ1 8K81	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Transcription Corepressor Activity Response To UV Re-entry Into Mitotic Cell Cycle Response To Ionizing Radiation Cyclin D1-CDK4 Complex Cyclin D1-CDK6 Complex Adherens Junction Netrin Receptor Binding Dorsal Root Ganglion Development Response To Fungicide MRF Binding Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling	None