INHBB and INHA

Number of citations: 0 (PubMedID 11134153)
Data Source: HPRD (in vitro)

		INHBB	INHA
Name		inhibin subunit beta B	inhibin subunit alpha
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery	Photoreceptor Outer Segment Photoreceptor Inner Segment Extracellular Region Extracellular Space Inhibin-betaglycan-ActRII Complex Neuronal Cell Body Inhibin A Complex Inhibin B Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Inhibin Binding Protein-containing Complex Binding
	Biological Process	Ovarian Follicle Development Defense Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Wounding Response To Insecticide Pituitary Gland Development Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Response To Gonadotropin Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Cholesterol Seminiferous Tubule Development Cellular Response To Thyroid Hormone Stimulus Apoptotic Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Apoptotic Signaling Pathway	Skeletal System Development Ovarian Follicle Development Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Male Gonad Development Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Type II Interferon Production Regulation Of Cell Population Proliferation Negative Regulation Of Phosphorylation Hemoglobin Biosynthetic Process Negative Regulation Of B Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Cell Cycle Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion System Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Cycle
Pathways		Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin	Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones TGFBR3 regulates activin signaling
Diseases		None	Premature ovarian failure
GWAS		Age-related macular degeneration ( 23326517 ) Breast cancer ( 27117709 ) Breast cancer (estrogen-receptor negative) ( 27117709 ) Breast size ( 22747683 27182965 ) Obesity ( 21552555 ) Serum alkaline phosphatase levels ( 33547301 ) Urate levels ( 23263486 31985003 )	No GWAS studies recorded
Interacting Genes		12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 CRIPTO FNTA IGSF1 INHA INHBA INHBC	5 interacting genes: FST INHBA INHBB SIAH1 TGFBR3
Entrez ID		3625	3623
HPRD ID		00934	00933
Ensembl ID		ENSG00000163083	ENSG00000123999
Uniprot IDs		P09529	P05111
PDB IDs		7U5O	Not available
GO Terms Enriched among Interactors		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Inhibin Binding Activin Receptor Activity Growth Factor Binding Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Activin Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Activin Receptor Activity, Type II Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Ossification BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Signal Transduction Nodal Signaling Pathway System Development Regulation Of SMAD Protein Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Regulation Of Bone Mineralization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling BMP Signaling Pathway Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Inhibin A Complex Protein Kinase Activity Regionalization Endothelial Cell Differentiation Cellular Response To BMP Stimulus Inhibin-betaglycan-ActRII Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Kinase Activity Positive Regulation Of Erythrocyte Differentiation	Cardiac Fibroblast Cell Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Gonadotropin Positive Regulation Of Ovulation Negative Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Activin Binding Gonad Development Positive Regulation Of Apoptotic Signaling Pathway Response To Follicle-stimulating Hormone Cellular Response To Cholesterol Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Sterol Reproductive Structure Development Response To Cholesterol Cell Surface Receptor Signaling Pathway Response To Ketone Female Gonad Development Activin Receptor Signaling Pathway Developmental Process Involved In Reproduction Response To Alcohol Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Differentiation Response To Peptide Hormone Positive Regulation Of SMAD Protein Signal Transduction Cardiac Cell Development Ovarian Follicle Development Regulation Of Apoptotic Signaling Pathway Cellular Developmental Process Negative Regulation Of Hormone Secretion Regulation Of SMAD Protein Signal Transduction Regulation Of Signal Transduction Reproductive Process Erythrocyte Differentiation Positive Regulation Of Reproductive Process Roof Of Mouth Development Hair Cycle Process Animal Organ Development BMP Signaling Pathway Positive Regulation Of Apoptotic Process Extracellular Space Activin A Complex Anatomical Structure Morphogenesis Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Signaling Animal Organ Morphogenesis Negative Regulation Of Cell Communication