IL15 and IL15RA

Number of citations: 38 (PubMedID 7641685)
Data Source: HPRD (in vitro, in vivo)

		IL15	IL15RA
Name		interleukin 15	interleukin 15 receptor subunit alpha
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Golgi Apparatus Cytosol Nuclear Speck	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Protein Binding	Cytokine Receptor Activity Protein Binding Protein Kinase Binding Interleukin-15 Receptor Activity
	Biological Process	Natural Killer Cell Differentiation Natural Killer Cell Proliferation Positive Regulation Of Cytokine Production NK T Cell Proliferation Immune Response Signal Transduction Tyrosine Phosphorylation Of STAT Protein Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Macrophage Differentiation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Tissue Remodeling Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Neutrophil Activation Extrathymic T Cell Selection Regulation Of T Cell Differentiation Cell Maturation Lymph Node Development Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Negative Regulation Of Cold-induced Thermogenesis	Natural Killer Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Neuron Projection Development Response To Nutrient Levels Positive Regulation Of Natural Killer Cell Differentiation Interleukin-15-mediated Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Interleukin-15 signaling Interleukin-15 signaling	Interleukin-15 signaling Interleukin-15 signaling
Drugs		Cefazolin	None
GWAS		Insomnia ( 29520036 ) Malaria ( 31844061 ) Post-traumatic stress disorder symptoms in trauma-exposed soldiers ( 30999091 ) Response to treatment for acute lymphoblastic leukemia ( 19176441 )	Alopecia areata ( 25608926 ) Asthma ( 31619474 31959851 ) Asthma (bronchodilator response) ( 23508266 ) Atopic dermatitis ( 26482879 ) Blood protein levels ( 30072576 ) Diisocyanate-induced asthma ( 25918132 ) Inflammatory bowel disease ( 23128233 ) Medication use (thyroid preparations) ( 31015401 ) Neuroblastoma (pediatric) ( 32599975 ) Soluble interleukin-2 receptor subunit alpha ( 26293465 )
Interacting Genes		9 interacting genes: APP IL15RA IL2RB IL2RG POLR1H S100A6 S100P STAT5B TRAF3	12 interacting genes: AXL BCL10 CASK CDK2 CDK4 IL15 IL2RB IL2RG PIAS4 RCVRN SYK TRAF2
Entrez ID		3600	3601
HPRD ID		02776	03045
Ensembl ID		ENSG00000164136	ENSG00000134470
Uniprot IDs		P40933	A0A0A0MS77 G8CVM3 Q13261
PDB IDs		2XQB 2Z3Q 2Z3R 4GS7	2ERS 2Z3Q 2Z3R 4GS7
GO Terms Enriched among Interactors		Interleukin-15 Receptor Activity Interleukin-15-mediated Signaling Pathway Positive Regulation Of Endocytosis Interleukin-2 Binding Interleukin-2 Receptor Activity Cytokine-mediated Signaling Pathway Cytokine Receptor Activity Positive Regulation Of Phagocytosis Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Endocytosis Endosome Interleukin-2-mediated Signaling Pathway Regulation Of Phagocytosis Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell Activation Transition Metal Ion Binding Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of B Cell Differentiation Natural Killer Cell Differentiation Positive Regulation Of Immune System Process Positive Regulation Of Natural Killer Cell Activation Regulation Of Vesicle-mediated Transport Immune System Process Positive Regulation Of Leukocyte Differentiation Leukocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of B Cell Differentiation Immune Response Regulation Of Lymphocyte Differentiation Cell Surface Regulation Of Cell Activation Cell Activation T Cell Differentiation In Thymus Lymphocyte Differentiation Regulation Of Natural Killer Cell Activation Protein Homodimerization Activity Natural Killer Cell Activation Coreceptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Mononuclear Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Transport Positive Regulation Of Lymphocyte Activation Regulation Of Immune System Process External Side Of Plasma Membrane	Positive Regulation Of Endocytosis Interleukin-15-mediated Signaling Pathway Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Interleukin-15 Receptor Activity Interleukin-2 Binding Interleukin-2 Receptor Activity Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Lymphocyte Differentiation Signal Transduction Immune Response Positive Regulation Of Cell Activation Positive Regulation Of Mast Cell Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Positive Regulation Of Transport Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Differentiation Cellular Response To Oxygen-containing Compound Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Kinase Activity Regulation Of Lymphocyte Activation Positive Regulation Of Phagocytosis Lymphocyte Differentiation Positive Regulation Of Natural Killer Cell Differentiation Leukocyte Activation Positive Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Transport Interleukin-2-mediated Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Leukocyte Cell-cell Adhesion Kinase Activity Regulation Of Natural Killer Cell Differentiation T Cell Activation Regulation Of Cell Activation Positive Regulation Of Cellular Component Organization Cell Activation Transferase Activity Cellular Response To Nitric Oxide Mononuclear Cell Differentiation Cellular Response To Reactive Nitrogen Species Positive Regulation Of Cell-cell Adhesion Positive Regulation Of B Cell Differentiation