IL12RB1 and STAT4

Number of citations: 0 (PubMedID 10415122)
Data Source: HPRD (in vivo)

		IL12RB1	STAT4
Name		interleukin 12 receptor subunit beta 1	signal transducer and activator of transcription 4
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-12 Receptor Binding Coreceptor Activity Interleukin-12 Receptor Activity Cytokine Binding Interleukin-23 Binding Interleukin-23 Receptor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T-helper 1 Type Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation T-helper 1 Cell Differentiation Cellular Response To Type II Interferon Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper 17 Cell Lineage Commitment	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Interleukin-12-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Interleukin-6
Pathways		Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling	Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Diseases		IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency	None
GWAS		Mental health study participation (completed survey) ( 31263887 ) Pulmonary function in asthmatics ( 23541324 ) Systemic sclerosis ( 30572963 31672989 ) Waist circumference adjusted for body mass index ( 34021172 )	Arthritis (juvenile idiopathic) ( 33106285 ) Autoimmune thyroid disease ( 32581359 ) Autoimmune traits (pleiotropy) ( 30572963 ) Behcet's disease ( 23291587 23001997 ) Celiac disease ( 22057235 30572963 25920553 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Eosinophil count ( 32888494 ) Gamma glutamyl transferase levels ( 29403010 ) Generalized epilepsy ( 30531953 ) Hepatocellular carcinoma in hepatitis B infection ( 23242368 ) Idiopathic inflammatory myopathy ( 26362759 ) Inflammatory bowel disease ( 23128233 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Limited cutaneous systemic scleroderma ( 29293537 ) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 24076602 31604244 ) Nontyphoidal Salmonella bacteraemia ( 29523850 ) Primary biliary cholangitis ( 26394269 28425483 23000144 21399635 ) Primary biliary cirrhosis ( 22961000 ) Rheumatoid arthritis ( 30572963 23143596 24390342 32723749 30423114 20453841 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Sjögren's syndrome ( 28076899 24097067 24097066 ) Systemic lupus erythematosus ( 32771030 28714469 33272962 19165918 23273568 18204098 19838193 19838195 21408207 23053960 24871463 26316170 26606652 26502338 27399966 26663301 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic sclerosis ( 28314753 33069728 20383147 29293537 21750679 31672989 21779181 30572963 24387989 ) Systemic sclerosis (anti-centromere-positive) ( 29293537 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Type 1 diabetes ( 34127860 ) Vitiligo ( 27723757 )
Interacting Genes		7 interacting genes: CFTR IL12B IL12RB2 IL23A IL23R SNRPD3 STAT4	13 interacting genes: ADRB2 CREBBP CRK IL12RB1 IL12RB2 JUN MAP2K6 MAPK14 NMI PIAS2 SH2D1B STAT3 ZNF467
Entrez ID		3594	6775
HPRD ID		03363	02779
Ensembl ID		ENSG00000096996	ENSG00000138378
Uniprot IDs		P42701	Q14765
PDB IDs		6WDP 6WDQ 8C7M 8ODX 8OE4 8XRP 8YI7	Not available
GO Terms Enriched among Interactors		Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Cell Fate Commitment Positive Regulation Of T-helper 17 Type Immune Response Positive Regulation Of T-helper Cell Differentiation Regulation Of T-helper 17 Cell Differentiation Regulation Of T-helper 17 Type Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Fate Commitment Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Interleukin-12-mediated Signaling Pathway Positive Regulation Of NK T Cell Activation Regulation Of T-helper Cell Differentiation Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Memory T Cell Differentiation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Alpha-beta T Cell Activation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production T-helper 1 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Interleukin-10 Production Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of T Cell Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Interleukin-17 Production Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Alpha-beta T Cell Activation Interleukin-23 Receptor Binding Interleukin-23 Complex Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Adaptive Immune Response Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of T Cell Mediated Cytotoxicity T-helper Cell Differentiation Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Activation Positive Regulation Of Interleukin-12 Production T Cell Differentiation Involved In Immune Response Regulation Of Defense Response To Virus By Host Regulation Of T Cell Mediated Cytotoxicity	Regulation Of Defense Response Immune System Process Cell Surface Receptor Signaling Pathway Interleukin-23-mediated Signaling Pathway Response To Stress NLRP1 Inflammasome Complex Assembly Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Interleukin-12-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Energy Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Immune Response Cellular Response To UV-B MAP Kinase Kinase Activity Cell Activation T-helper 1 Cell Differentiation Cellular Response To UV Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Light Stimulus Response To UV-B Stress-activated MAPK Cascade Negative Regulation Of Defense Response P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade SMAD Protein Signal Transduction Response To Muscle Stretch Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Immune System Process Response To Peptide Leukocyte Activation Canonical Inflammasome Complex Assembly Positive Regulation Of Erythrocyte Differentiation Temperature Homeostasis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To UV Lipopolysaccharide-mediated Signaling Pathway T-helper Cell Differentiation Interleukin-12 Receptor Activity Negative Regulation Of Integrin Biosynthetic Process Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Pyroptotic Inflammatory Response Leukocyte Differentiation