AQP1 and CSRNP1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		AQP1	CSRNP1
Name		aquaporin 1 (Colton blood group)	cysteine and serine rich nuclear protein 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Brush Border Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Axon Brush Border Membrane Nuclear Membrane Sarcolemma Apical Part Of Cell Extracellular Exosome Ankyrin-1 Complex	Chromatin Nucleus
	Molecular Function	Intracellularly CGMP-activated Cation Channel Activity Potassium Channel Activity Water Transmembrane Transporter Activity Protein Binding Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity Transmembrane Transporter Activity Nitric Oxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Identical Protein Binding Ephrin Receptor Binding Hydrogen Peroxide Channel Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Renal Water Homeostasis Glomerular Filtration Renal Water Transport Potassium Ion Transport Water Transport Cell Volume Homeostasis Hyperosmotic Response Intracellular Water Homeostasis Fibroblast Migration Positive Regulation Of Fibroblast Migration Carbon Dioxide Transport Glycerol Transmembrane Transport Cell Migration Sensory Perception Of Pain Cellular Homeostasis CGMP-mediated Signaling Lateral Ventricle Development Pancreatic Juice Secretion Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Secretion By Cell Cerebrospinal Fluid Secretion Secretory Granule Organization Cellular Response To UV Transepithelial Water Transport Carbon Dioxide Transmembrane Transport Wound Healing Odontogenesis Negative Regulation Of Apoptotic Process Lipid Digestion Positive Regulation Of Angiogenesis Positive Regulation Of Saliva Secretion Positive Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Defense Response To Gram-negative Bacterium Multicellular Organismal-level Water Homeostasis Corticotropin Secretion Establishment Of Localization In Cell Transmembrane Transport Renal Water Absorption Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Copper Ion Cellular Response To Mercury Ion Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Hypoxia Cellular Response To Salt Stress Cellular Hyperosmotic Response Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Potassium Ion Transmembrane Transport Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development Metanephric Glomerulus Vasculature Development Ammonium Transmembrane Transport Hydrogen Peroxide Transmembrane Transport Monoatomic Cation Transmembrane Transport	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Post-embryonic Development Positive Regulation Of Transcription By RNA Polymerase II Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins Developmental Lineage of Pancreatic Ductal Cells	None
Drugs		Acetazolamide B-nonylglucoside Mersalyl	None
GWAS		Fractures ( 30598549 ) Heel bone mineral density ( 28869591 30598549 ) hemolysis of donated blood (osmotic) ( 34014839 ) Huntington's disease progression ( 28642124 ) Kidney stones ( 31729369 ) Nephrolithiasis ( 22396660 ) Systolic blood pressure ( 30224653 ) Total body bone mineral density ( 29304378 ) Triglyceride levels ( 34074324 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Brain-derived neurotrophic factor levels ( 33345186 ) Chronic lymphocytic leukemia ( 26956414 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Daytime sleep phenotypes ( 27126917 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Social communication problems ( 24564958 )
Interacting Genes		134 interacting genes: ADAMTSL4 AMOT AQP6 BCL2L13 BEGAIN BLZF1 BMF CCDC136 CCDC57 CCDC85B CCNDBP1 CD79A CDR2 CEP44 CLDN5 COMP CPLX4 CREB3 CRTAC1 CSRNP1 CYSRT1 EFEMP2 EPHB2 ESM1 EVI2B FAM161A FAM209A FNDC9 FOS FSD2 GET1 GJB5 GLI1 GOLGA2 GPR37L1 GPRASP3 GPX8 IFT20 IGFBP6 IHO1 IKZF2 IKZF3 IL21R KCNK5 KCTD17 KCTD9 KHDRBS3 KIAA1958 KLHL26 KRT31 KRT33B KRT37 KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-4 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE1A LDLRAD1 LDOC1 LIME1 LMNA LPXN LRRC59 MDFI MGST3 MID2 MIF4GD MKRN3 MRM1 MTUS2 MUC1 MYF5 NBPF19 NBPF22P NBPF6 NOTCH2NLA NUTM1 PGPEP1 PICK1 PLA2G10 PLSCR2 PPARA PRDM14 PRDM6 RBAK REL RGS17 RGS20 RIMBP3 RNF122 SAR1A SIAH1 SIVA1 SLC15A2 SLC39A2 SPDYA SPRED1 SPRED2 SPRY2 SPRY3 SPRYD7 SSMEM1 TCF4 TMEM237 TMEM38B TMEM45B TMEM80 TMPRSS2 TNK2 TNS2 TRAF1 TRAF2 TRIM23 TRIM37 TRIM41 TRIM42 TRIM7 TRIP6 TSC1 ZBTB39 ZIM2 ZNF16 ZNF398 ZNF792	6 interacting genes: AQP1 PPP1CA PRPF18 TCEANC ZNF417 ZNF587
Entrez ID		358	64651
HPRD ID		00140	07347
Ensembl ID		ENSG00000240583	ENSG00000144655
Uniprot IDs		A0A024RA31 P29972	Q96S65
PDB IDs		1FQY 1H6I 1IH5 4CSK 6POJ 7UZE 8CT2 8CTE	Not available
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Protein Binding Identical Protein Binding Negative Regulation Of Lens Fiber Cell Differentiation Hair Cycle Regulation Of Lens Fiber Cell Differentiation Tumor Necrosis Factor Receptor Binding Cellular Developmental Process	Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development U2-type Post-spliceosomal Complex Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Generation Of Catalytic Spliceosome For Second Transesterification Step Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Renal Water Absorption Carbon Dioxide Transmembrane Transporter Activity Positive Regulation Of Saliva Secretion Glomerulus Vasculature Development Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Transepithelial Water Transport Hydrogen Peroxide Transmembrane Transport Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Intracellularly CGMP-activated Cation Channel Activity Carbon Dioxide Transmembrane Transport Lipid Digestion Pancreatic Juice Secretion Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Positive Regulation Of Termination Of RNA Polymerase II Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Ankyrin-1 Complex Renal Water Transport Glycerol Transmembrane Transport Nucleus Intracellular Water Homeostasis Regulation Of Saliva Secretion RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process PTW/PP1 Phosphatase Complex Ammonium Channel Activity Polyol Transmembrane Transport Response To Mercury Ion Double-strand Break Repair Via Alternative Nonhomologous End Joining Ammonium Transmembrane Transport Cellular Response To Salt Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Digestive System Process Epithelial Fluid Transport