IL2RG and ICAM1

Number of citations: 33 (PubMedID 1976256)
Data Source: HPRD (in vivo)

		IL2RG	ICAM1
Name		interleukin 2 receptor subunit gamma	intercellular adhesion molecule 1
Structure
GO Annotations	Cellular Component	Nucleoplasm Endosome Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome
	Molecular Function	Cytokine Receptor Activity Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Coreceptor Activity Cytokine Binding Interleukin-2 Binding Interleukin-15 Receptor Activity	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Mature B Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Immune System Process Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Homeostasis Lymphocyte Differentiation B Cell Differentiation Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Positive Regulation Of B Cell Differentiation Positive Regulation Of Phagocytosis	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Interleukin-7 signaling Interleukin-7 signaling RAF/MAP kinase cascade Interleukin-4 and Interleukin-13 signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-21 signaling Interleukin receptor SHC signaling STAT3 nuclear events downstream of ALK signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		Denileukin diftitox Aldesleukin Resatorvid	Natalizumab Hyaluronic acid Nafamostat
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Allograft rejection
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 ) Crohn's disease ( 21102463 ) Height ( 31562340 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low white blood cell count (conditioned on rs2814778) ( 29596498 ) Lymphocyte count ( 27863252 32888494 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Soluble ICAM-1 ( 18604267 21533024 31217265 ) White blood cell count ( 32888494 )
Interacting Genes		27 interacting genes: AXL CAPNS1 ERRFI1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 KRTAP10-8 KRTAP5-7 NOTCH2NLA PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2	16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2
Entrez ID		3561	3383
HPRD ID		02391	00996
Ensembl ID		ENSG00000147168	ENSG00000090339
Uniprot IDs		H0Y8J6 P31785	A0A384MEK5 P05362
PDB IDs		2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7 5M5E 6OEL 7S2R 8ENT 8EPA 9JQT	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7
GO Terms Enriched among Interactors		Cytokine-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Positive Regulation Of Lymphocyte Differentiation Regulation Of Lymphocyte Differentiation Lymphocyte Activation Cell Surface Receptor Signaling Pathway Interleukin-4-mediated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Interleukin-9-mediated Signaling Pathway Leukocyte Activation Regulation Of Hemopoiesis Lymphocyte Differentiation Cell Activation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via STAT Mononuclear Cell Differentiation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Leukocyte Differentiation Regulation Of Multicellular Organismal Development Positive Regulation Of Cell Development Positive Regulation Of T Cell Differentiation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Regulation Of Cell-cell Adhesion Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Natural Killer Cell Differentiation Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Signal Transduction Cytokine Receptor Activity Regulation Of T-helper Cell Differentiation Positive Regulation Of Immune System Process B Cell Activation Regulation Of Cell Differentiation Regulation Of Cytokine Production Immune System Process Natural Killer Cell Differentiation Regulation Of Immune System Process Natural Killer Cell Activation	Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion