IL1R1 and IL1F10

Number of citations: 0 (PubMedID 11278614)
Data Source: HPRD (in vitro)

		IL1R1	IL1F10
Name		interleukin 1 receptor type 1	interleukin 1 family member 10
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Protease Binding Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Hydrolase Activity Interleukin-1 Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Cytokine Activity Interleukin-1 Receptor Binding Protein Binding
	Biological Process	Inflammatory Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Positive Regulation Of Type II Interferon Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS	Interleukin-38 signaling Interleukin-36 pathway
Drugs		Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)	None
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Alanine aminotransferase levels ( 33547301 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 ) Ankylosing spondylitis ( 23749187 ) Asthma ( 31959851 31619474 29785011 30929738 22561531 ) Asthma (childhood onset) ( 30929738 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Blood protein levels ( 30072576 ) C-reactive protein levels ( 30388399 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Inflammatory bowel disease ( 28067908 23128233 ) Primary biliary cholangitis ( 26394269 ) Serum protein levels (sST2) ( 23999434 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 33547301 ) C-reactive protein ( 22939635 ) C-reactive protein levels ( 33339817 21300955 30388399 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Coronary artery disease ( 29212778 ) Dysmenorrheic pain ( 27454463 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Inflammatory biomarkers ( 24182552 ) Interleukin-1-receptor antagonist levels ( 22205395 ) Interleukin-6 levels ( 33517400 ) Low density lipoprotein cholesterol levels ( 32154731 ) Myocardial infarction ( 33532862 ) Serum alkaline phosphatase levels ( 33547301 ) Stroke ( 26089329 ) Total cholesterol levels ( 29083408 )
Interacting Genes		11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP	2 interacting genes: IL1R1 IMPDH2
Entrez ID		3554	84639
HPRD ID		00994	17144
Ensembl ID		ENSG00000115594	ENSG00000136697
Uniprot IDs		B8ZZW4 P14778	Q8WWZ1
PDB IDs		1G0Y 1IRA 1ITB 4DEP 4GAF	5BOW
GO Terms Enriched among Interactors		Interleukin-1 Receptor Binding Inflammatory Response Interleukin-1-mediated Signaling Pathway Defense Response Cytokine-mediated Signaling Pathway Response To Stress Immune Response Acute-phase Response Immune System Process Cell Surface Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Acute Inflammatory Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Interleukin-6 Production Interleukin-1, Type I Receptor Binding Positive Regulation Of Cytokine Production Regulation Of Chemokine Production Response To Lipopolysaccharide Fever Generation Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Toll-like Receptor 4 Signaling Pathway Response To Molecule Of Bacterial Origin Signal Transduction Regulation Of Interleukin-6 Production Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immature T Cell Proliferation In Thymus Molecular Adaptor Activity Cell Surface Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Binding Response To Lipid Heat Generation Cellular Response To Lipid Toll Signaling Pathway Cytokine Activity Cellular Response To Oxygen-containing Compound Interleukin-33-mediated Signaling Pathway Negative Regulation Of Interleukin-1-mediated Signaling Pathway Negative Regulation Of Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Chemokine Production Extrinsic Component Of Plasma Membrane Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity	Interleukin-1 Binding Smooth Muscle Adaptation Response To Peptide Positive Regulation Of Neutrophil Extravasation Regulation Of Neutrophil Extravasation Interleukin-1, Type I, Activating Receptor Activity Positive Regulation Of Interleukin-1-mediated Signaling Pathway Response To Cytokine Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Interleukin-1 Receptor Activity Positive Regulation Of T-helper 1 Cell Cytokine Production GTP Biosynthetic Process 'de Novo' XMP Biosynthetic Process IMP Dehydrogenase Activity Regulation Of Interleukin-1-mediated Signaling Pathway Platelet-derived Growth Factor Receptor Binding GMP Biosynthetic Process NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Positive Regulation Of Cellular Extravasation Positive Regulation Of T-helper 1 Type Immune Response Purine Ribonucleoside Monophosphate Biosynthetic Process GTP Metabolic Process Cellular Response To Interleukin-4 Interleukin-1-mediated Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Interleukin-4 GMP Metabolic Process Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Neutrophil Migration Ribonucleoside Monophosphate Biosynthetic Process Regulation Of Cellular Extravasation Regulation Of T Cell Cytokine Production Regulation Of Neutrophil Migration Nucleoside Monophosphate Biosynthetic Process Cytokine Receptor Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Peroxisomal Membrane Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Type II Interferon Production Positive Regulation Of T Cell Mediated Immunity Nucleoside Monophosphate Metabolic Process Response To Interleukin-1 Positive Regulation Of Cytokine Production Involved In Immune Response Immune System Process Nucleoside Triphosphate Biosynthetic Process Regulation Of T Cell Mediated Immunity Protease Binding Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Type II Interferon Production Extracellular Region