APP and NUMB

Number of citations: 35 (PubMedID 12011466)
Data Source: HPRD (in vitro, in vivo)

		APP	NUMB
Name		amyloid beta precursor protein	NUMB endocytic adaptor protein
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nuclear Envelope Lumen Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosome Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Golgi Lumen Golgi-associated Vesicle Cytosol Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Membrane Axon Dendrite Growth Cone Platelet Alpha Granule Platelet Alpha Granule Lumen Cytoplasmic Vesicle Early Endosome Membrane Endosome Lumen Trans-Golgi Network Membrane Dendrite Membrane Protein-containing Complex Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle High-density Lipoprotein Particle Cell Projection Neuron Projection Dendritic Spine Dendritic Shaft Perikaryon Receptor Complex Cell Body Main Axon Membrane Raft Synapse Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Endosome To Plasma Membrane Transport Vesicle Synaptic Membrane Astrocyte Projection Presynapse Postsynapse Neuronal Dense Core Vesicle Amyloid-beta Complex Growth Cone Lamellipodium Lipoprotein Particle Growth Cone Filopodium	Cytoplasm Endosome Early Endosome Plasma Membrane Clathrin-coated Pit Focal Adhesion Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Glutamatergic Synapse
	Molecular Function	G Protein-coupled Receptor Binding DNA Binding Chromatin Binding Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Frizzled Binding Insulin Receptor Binding Integrin Binding Protein Binding Heparin Binding Peptidase Activator Activity Enzyme Binding Peptidase Inhibitor Activity Signaling Receptor Activator Activity Acetylcholine Receptor Activator Activity Acetylcholine Receptor Binding Apolipoprotein Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Metal Ion Binding Ephrin Receptor Binding Transition Metal Ion Binding Protein Heterodimerization Activity Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding RAGE Receptor Binding Protein-folding Chaperone Binding PTB Domain Binding Growth Factor Receptor Binding Amylin Binding Protein Serine/threonine Kinase Binding Molecular Function Activator Activity Heparan Sulfate Binding	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Response To Yeast Astrocyte Activation Involved In Immune Response Regulation Of Transcription By RNA Polymerase II Regulation Of Translation Intracellular Copper Ion Homeostasis Endocytosis Apoptotic Process Cell Adhesion G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Notch Signaling Pathway Chemical Synaptic Transmission Axonogenesis Central Nervous System Development Learning Or Memory Learning Memory Mating Behavior Locomotory Behavior Axo-dendritic Transport Negative Regulation Of Cell Population Proliferation Associative Learning Adult Locomotory Behavior Visual Learning Response To Lead Ion Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Auditory Stimulus Microglia Development Axon Midline Choice Point Recognition Neuron Remodeling Dendrite Development Calcium-mediated Signaling Antibacterial Humoral Response Antifungal Humoral Response Regulation Of Wnt Signaling Pathway Extracellular Matrix Organization Neuron Projection Development Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Regulation Of Toll-like Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Lipoprotein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Astrocyte Activation Regulation Of Long-term Neuronal Synaptic Plasticity Collateral Sprouting In Absence Of Injury Positive Regulation Of Inflammatory Response Regulation Of Synapse Structure Or Activity Synapse Organization Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Cell Activation Cognition Positive Chemotaxis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Homooligomerization Protein Tetramerization Regulation Of Neurotransmitter Uptake Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Low-density Lipoprotein Particle Mediated Signaling Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Manganese Ion Cellular Response To CAMP Cellular Response To Norepinephrine Stimulus Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Modulation Of Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Protein Localization To Nucleus Regulation Of Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of MiRNA Transcription Regulation Of Dendritic Spine Maintenance Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Blood Circulation Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Endothelin Production Positive Regulation Of Protein Import Cellular Response To Amyloid-beta Regulation Of Presynapse Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Regulation Of Response To Calcium Ion Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus Neuron Projection Maintenance Positive Regulation Of T Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Nervous System Development Neuroblast Proliferation Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1-dependent IKK and NF-kappa-B activation The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Gantenerumab Aducanumab Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form Lecanemab	None
Diseases		Alzheimer's disease (AD)	None
GWAS		Alzheimer's disease ( 34099642 ) Cerebrospinal fluid α-synuclein levels ( 29959729 ) Glaucoma (primary open-angle) ( 33627673 ) HDL cholesterol levels in HIV infection ( 33109212 ) Longitudinal change in brain amyloid plaque burden ( 26268530 ) Spatial processing ( 31596458 )	Bipolar disorder with mood-incongruent psychosis ( 23092984 ) Coronary artery calcification ( 17903303 ) Hemoglobin ( 32888494 ) Macular thickness ( 30535121 ) Multisite chronic pain ( 31194737 33830993 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Interacting Genes		2116 interacting genes: - - - A2M AAK1 AAMDC ABCB7 ABCF1 ABHD10 ABHD11 ABL1 ABLIM1 ABR ABT1 ACAA2 ACAD10 ACAD11 ACBD4 ACBD6 ACHE ACKR2 ACLY ACO1 ACO2 ACSBG1 ACSL3 ACSL4 ACTL6B ACTL7A ACTL7B ACTR1B ACY1 ACYP1 ADAD2 ADAM22 ADAP2 ADARB1 ADAT2 ADD2 ADH4 ADH5 ADI1 ADRM1 AEBP2 AFAP1L2 AFG3L1P AFG3L2 AGAP1 AGER AGFG1 AGFG2 AGO1 AGO4 AGPAT3 AGR2 AHDC1 AHSA1 AICDA AIDA AIFM3 AIMP1 AIMP2 AK4 AKAP13 AKNAD1 AKT1 AKT2 ALDH2 ALDH4A1 ALDH7A1 ALDH8A1 ALDOB ALKBH7 ALKBH8 ALOX5 AMOT ANGPTL7 ANKRA2 ANKRD13D ANKRD36BP1 ANKRD39 ANKRD45 ANKRD50 ANKS1B ANKS4B ANKS6 ANKZF1 ANP32B ANXA2 ANXA5 ANXA8 ANXA9 AP1M2 AP2A2 AP4S1 APBA1 APBA2 APBA3 APBB1 APBB2 APBB3 APEX1 APEX2 APLF APOA1 APOBEC3G APOBEC3H APOE APPBP2 APRT ARAP1 ARCN1 AREG ARF6 ARFGAP1 ARFGAP3 ARFIP2 ARGLU1 ARHGAP15 ARHGAP17 ARHGAP24 ARHGAP9 ARHGDIB ARHGEF40 ARHGEF5 ARID3A ARID3B ARL4C ARL4D ARL5A ARL6IP6 ARL8B ARMC1 ARMC7 ARMC9 ARMCX3 ARNT2 ARPC1B ARPP19 ARRDC1 ART4 ASB6 ASCL3 ASGR1 ASH1L ASMTL ASPH ASPSCR1 ASS1 ASXL1 ASXL2 ATAT1 ATCAY ATF2 ATF4 ATF6 ATG12 ATG13 ATG16L1 ATG7 ATL3 ATOSB ATP5F1A ATP5F1C ATP5PD ATP5PO ATP6V1E1 ATP6V1G1 ATPAF2 ATRAID ATXN3 ATXN7L3 AURKA AURKB AVPI1 BAALC-AS2 BACE1 BACE2 BAIAP2 BBX BCAP31 BCAR3 BCAT2 BCKDK BCL11A BCL2A1 BCL2L11 BCL2L13 BCL7C BDH1 BDNF BEGAIN BEND2 BEND5 BET1L BGN BHMT2 BIK BIN1 BIN3-IT1 BKGD BLMH BLOC1S1 BLOC1S2 BLOC1S5 BLOC1S6 BMPR1B BMX BNIP1 BOD1 BOLA1 BRD3 BRF1 BRME1 BRMS1 BRWD1 BSND BTF3 BTK BUD31 BYSL C10orf88 C11orf52 C11orf71 C14orf93 C15orf39 C16orf78 C19orf12 C19orf18 C19orf33 C1D C1orf105 C1orf115 C1orf116 C1orf174 C1orf35 C1orf87 C22orf46P C2orf49 C3orf20 C3orf33 C3orf36 C3orf62 C4orf46 C5orf15 C6orf118 C8orf33 C9orf43 C9orf72 C9orf78 CAAP1 CACNB1 CACNG2 CACNG3 CALCOCO1 CALR CAMK1 CAMK1D CAMKK1 CAMKK2 CAMKMT CAMKV CAPNS2 CAPRIN1 CAPSL CARF CARNMT1 CARS1 CASP3 CASP4 CASP6 CASP8 CASZ1 CAT CATIP CAV1 CAVIN4 CBFA2T2 CCDC106 CCDC107 CCDC14 CCDC144NL CCDC149 CCDC15 CCDC190 CCDC28B CCDC33 CCDC40 CCDC59 CCDC60 CCDC88C CCIN CCL13 CCL26 CCNB1IP1 CCNB3 CCND3 CCNE2 CCNG1 CCNL1 CCR2 CCSER2 CCT7 CCT8 CCZ1B CD300LB CD300LF CD36 CD58 CD74 CDC20 CDC25A CDC37 CDC42EP4 CDC7 CDCA3 CDCA7 CDIPT CDK16 CDK17 CDK18 CDK2AP2 CDK3 CDK4 CDK5 CDK5R1 CDK7 CDKL2 CDKL3 CDKN1A CDKN2B CDKN2D CDPF1 CEACAM6 CELF1 CELF2 CELF4 CENPB CENPI CENPQ CENPS CENPT CEP250 CEP350 CEP57 CERK CFAP298 CFAP299 CFAP53 CFAP58 CFDP1 CFHR2 CFL1 CGB3 CHAC2 CHAF1B CHCHD6 CHD9 CHEK1 CHEK2 CHGB CHID1 CHKA CHLSN CHMP3 CHRAC1 CHRNA7 CHTOP CHURC1 CIAO3 CIART CILK1 CINP CIRBP CISD2 CLASRP CLDN16 CLDN20 CLDN3 CLEC3B CLIC3 CLIP4 CLK3 CLP1 CLU CLUAP1 CMAS CMTM2 CMTM3 CNDP1 CNOT7 CNPY2 COA5 COASY COIL COL11A1 COL14A1 COL18A1 COL1A2 COL25A1 COL4A1 COL4A2 COL4A3 COL4A5 COL4A6 COLEC12 COMMD2 COPB1 COPS5 COPS7B COPZ1 COQ6 COX4I1 COX4I2 COX6A2 COXFA4 CPEB1 CPED1 CPLX2 CRACR2B CRADD CRBN CREBBP CRHR2 CRIP2 CRYAB CSAG1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK2A1 CSRP1 CST2 CSTF2 CTBP2 CTF1 CTNNA1 CTNNB1 CTNND1 CTSB CTSD CUL4B CWC15 CWF19L2 CXCL14 CXCL16 CXXC4 CYB561D2 CYB5B CYP20A1 DAB1 DAB2 DAPK2 DCAF7 DCDC2 DCLK1 DCTN6 DCTPP1 DCUN1D2 DCX DCXR DDHD2 DDRGK1 DDX1 DDX10 DDX17 DDX18 DDX19B DDX20 DDX42 DDX43 DDX47 DDX49 DDX54 DDX55 DECR1 DECR2 DEDD DEF6 DEFA6 DENND1C DENND6B DEPTOR DERL1 DFFB DGCR6 DGCR8 DGLUCY DGUOK DHRS7B DHRSX DHX16 DHX58 DIDO1 DIMT1 DIO3 DIRAS1 DIXDC1 DLGAP1-AS2 DLGAP5 DLK2 DMAC1 DMD DMKN DMTN DNAAF2 DNAH14 DNAJB1 DNAJB14 DNAJB6 DNAJB7 DNAJC12 DNAJC19 DNAJC4 DNAJC8 DNALI1 DNM2 DPCD DPP3 DPY19L2P1 DPY19L2P4 DRAM1 DRAP1 DSCR9 DSN1 DTD2 DTWD1 DUS3L DUSP12 DUSP21 DUSP3 DUSP4 DYNC1LI2 DYNLRB2 DYNLT1 DYRK1A DYRK2 DZIP1L E2F6 E2F8 EAF1 EBF4 EBP ECH1 ECHDC1 ECHDC2 ECI1 ECI2 ECSIT EEF1B2 EEF1D EEPD1 EFHD2 EFS EGFR EHF EIF1 EIF1AX EIF2A EIF2B2 EIF2B5 EIF2S2 EIF3F EIF3G EIF3M EIF4E EIF4E2 EIF5 EIF6 ELF2 ELK1 ELK3 EMC8 EME1 EMG1 ENKD1 ENO3 ENTR1 ENY2 EOGT EP400P1 EPB41 EPB41L1 EPB41L2 EPB41L4A EPB41L5 EPHB2 EPHB4 EPS8L2 ERC1 ERCC1 ERG ERH ERMN ERVFRD-1 ESRRG ETFB ETHE1 ETNPPL ETS1 ETV3 ETV4 ETV5 EVI2A EXOC3 EXOC6 EXOSC1 EXOSC3 EXOSC7 F12 FAAH2 FAAP100 FAAP24 FAM114A2 FAM131C FAM133B FAM151A FAM184A FAM200A FAM27E3 FAM32A FAM3A FAM3B FAM47B FAM50A FAM53A FAM90A1 FANCI FANCM FBF1 FBLN1 FBXL2 FBXL7 FBXO38 FBXW9 FCF1 FCGR3A FCHO1 FDX2 FEN1 FERMT2 FERMT3 FES FEZF2 FGA FGB FGF12 FGF13 FGF16 FGFBP2 FGFR2 FGG FHIP2B FHL1 FHL2 FIBP FIG4 FILIP1 FIP1L1 FIRRM FITM1 FKBP1A FKBP5 FKBPL FLCN FLOT1 FLOT2 FMNL1 FMNL2 FMNL3 FN3KRP FNDC3A FOS FOXI1 FOXJ2 FOXS1 FRG1BP FRMD8 FSAF1 FSD1L FSIP1 FTSJ1 FUBP3 FUCA1 FYCO1 G3BP1 GABARAPL2 GABPA GABRA4 GADD45G GADD45GIP1 GAGE1 GAK GAL3ST1 GALE GALK1 GALNT12 GAPDH GAPDHS GAS2 GATD1 GATD3 GBA2 GCC1 GEMIN8 GFAP GGA1 GGA2 GGCT GIMAP4 GIMAP5 GIMAP6 GIMAP8 GJB1 GLB1L GLOD4 GLRB GLRX5 GNA12 GNA15 GNAT2 GNAZ GNB5 GNL2 GNLY GNPTAB GNRH2 GOLGA4 GOLM2 GORAB GORASP2 GOSR1 GOSR2 GPAM GPANK1 GPATCH1 GPATCH2L GPC1 GPKOW GPN2 GPR12 GPR137B GPR15 GPR61 GPR78 GPRASP3 GPT2 GRAMD1C GRAMD4 GRB10 GRB2 GRHL2 GRIN1 GSAP GSDMB GSK3B GSN GSPT2 GSTA1 GSTA3 GSTO1 GTF2E1 GTF2E2 GTF3A GTF3C6 GTPBP1 GTPBP8 GUCD1 GUCY1B1 GYG2 GYS1 H1-0 H1-1 H1-2 H2AC18 H2AC20 H2AC21 H2AZ2 H2BC1 H2BC14 H2BC3 H4C9 HADH HADHB HAGH HAPLN1 HAUS6 HAUS8 HAVCR2 HBD HBEGF HBG1 HBG2 HBS1L HBZ HCFC1R1 HCK HCP5 HDAC4 HDDC3 HDGF HELLS HERC2P9 HERPUD1 HEYL HGS HIC2 HIGD2A HIKESHI HINT2 HINT3 HIRIP3 HK1 HMBOX1 HMBS HMCES HMG20B HMGA1 HMGB2 HMGB4 HMGCS2 HMOX2 HNRNPA1 HOMER2 HOMER3 HOXB7 HOXC4 HOXC6 HP1BP3 HPGD HS3ST1 HSD17B10 HSPA13 HSPA2 HSPA9 HSPB7 HSPBP1 HSPD1 HSPG2 HTRA2 HYCC2 IARS1 IARS2 ICAM3 IDE IDO1 IER3 IFI16 IFI6 IFIH1 IFNA16 IFNA5 IFNA8 IFNW1 IFRD2 IFT81 IGBP1 IGF1R IGHM IGSF10 IGSF6 IK IKBIP IL15 IL18RAP IL1B IL1RL1 IL26 IL6-AS1 IL7 ILRUN IMP4 ING2 ING3 INIP INKA1 INKA2 INPP5B INS INTS12 INTS3 IPO4 IPO9 IQCH IREB2 IRF2 IRGC IRS1 ISL1 ISOC2 ITGA2 ITGA2B ITGA6 ITGB1BP1 ITGB3 ITGB3BP ITM2B JAGN1 JHY JTB JUN KANSL2 KAT5 KAT7 KATNA1 KCNAB1 KCNAB3 KCNE5 KCNIP4 KCNJ10 KCNJ5-AS1 KCNK5 KCNMB2 KCNN3 KCTD18 KIAA0319 KIAA0513 KIAA0825 KIAA0930 KIAA1143 KIAA1191 KIF2C KIF3A KIF3B KIF4A KIFC1 KIFC3 KIR2DL3 KISS1 KLC1 KLC2 KLC4 KLF12 KLF4 KLF6 KLF7 KLF8 KLHL32 KLK2 KLK7 KLK9 KNG1 KPNA2 KPNA4 KPTN KRABD5 KRT36 KRTAP10-7 KRTCAP2 KYAT1 L3MBTL4 LACRT LAD1 LAIR1 LAMA1 LAMC1 LANCL2 LAP3 LARP1B LARP4 LARP6 LARP7 LATS1 LCP2 LDLRAP1 LENG1 LETM2 LETMD1 LFNG LGALS2 LGALS3 LIG3 LIMA1 LIMCH1 LIMD1 LIMK1 LIMS2 LIN7A LINC00663 LINGO2 LIPT1 LLPH LMAN1 LMCD1 LMF2 LMNTD1 LMX1B LNX1 LPAR3 LPL LRP1 LRP1B LRP2 LRRC1 LRRC42 LRRC66 LRRC8D LRRK2 LSM6 LSMEM1 LSMEM2 LTV1 LUC7L2 LURAP1L LYPLA2 LYRM7 MAB21L2 MACROH2A1 MAD2L1 MAG MAGEA4 MAGEH1 MAIP1 MAK MAP1LC3A MAP2 MAP2K3 MAP2K4 MAP3K11 MAPK10 MAPK11 MAPK13 MAPK7 MAPK8 MAPK8IP1 MAPK8IP2 MAPKAPK3 MAPRE1 MAPRE2 MARCHF10 MARCHF3 MARS2 MAST1 MAST2 MAT2B MB MBD1 MBD4 MBNL1 MCC MCEE MCFD2 MCM10 MCM2 MCM5 MCM7 MCTP2 MDM2 MDM4 MED11 MED19 MED24 MED30 MED8 MED9 MEF2D MEIS2 MEOX1 MESD MEST METAP2 METTL16 METTL25 METTL2B METTL8 MICU1 MIER1 MITF MKKS MKNK1 MLLT3 MLLT6 MLX MMGT1 MMP12 MND1 MOB1A MOB1B MOB3A MOB3C MOBP MOGAT3 MORF4L1 MPG MPI MPP3 MPV17L MRAP2 MRM3 MROH8 MRPL1 MRPL10 MRPL11 MRPL19 MRPL20 MRPL24 MRPL27 MRPL28 MRPL3 MRPL34 MRPL35 MRPL48 MRPL49 MRPL52 MRPL53 MRPL58 MRPS18A MRPS2 MRPS24 MRPS6 MRPS9 MRRF MS4A2 MSI1 MSL3 MSMB MSTN MTCP1 MTERF3 MTERF4 MTFMT MTG1 MTMR14 MTRES1 MTRFR MTURN MUC1 MUCL3 MVB12A MX1 MXD1 MXI1 MYBBP1A MYC MYL1 MYL10 MYL5 MYNN MYOT MYOZ1 MYRF-AS1 MZT2A NAA25 NAA80 NAAA NAALADL2 NAE1 NAGA NAPA NAPG NARF NAT2 NAV1 NBPF3 NCBP3 NCR1 NCSTN NDEL1 NDP NDUFA2 NDUFA5 NDUFAF7 NDUFB1 NDUFB3 NDUFB6 NDUFS2 NDUFS4 NECAB1 NECAB3 NECAP1 NECAP2 NEDD9 NEIL1 NEK11 NELFA NF1 NFKBIB NFYA NGFR NGLY1 NID1 NIM1K NKIRAS1 NLN NLRP2 NME3 NME6 NME8 NMNAT1 NMNAT2 NMRK1 NMRK2 NMT2 NNAT NNMT NOB1 NOC2L NOL11 NOL12 NOL7 NOLC1 NOP16 NOS1AP NOS3 NOVA1 NPL NPM1 NR1D1 NR1H3 NRIP1 NSD2 NSRP1 NTM NTMT1 NTRK3 NUAK1 NUAK2 NUDT16L1 NUDT16L2P NUDT9 NUMB NUMBL NUP50 NUP62CL NUSAP1 NXF2 NXPE3 NXT2 OARD1 OAS2 OCEL1 OCIAD2 ODAM ODF2 ODF2L ODF4 OLFM1 OLFM3 OLFM4 OLFML2A OPA1 OPA3 OR2W1 OR4D6 OR6B3 OR7A5 ORC3 ORC4 ORC6 ORMDL1 ORMDL3 OSBPL11 OSBPL5 OSM OSTCP1 OSTF1 OTUB2 OTX2 OXSM OXSR1 P2RX6 P2RY2 PABIR1 PABPC3 PACRG PADI4 PAEP PAGR1 PAIP2 PAK1 PAK2 PAK4 PAK6 PAPSS2 PARD6A PARD6B PARP15 PARP3 PARVA PARVG PASD1 PATL1 PAX6 PAXIP1 PAXX PBRM1 PCBD1 PCBD2 PCBP1 PCDHA7 PCDHGA12 PCDHGC3 PCDHGC5 PCIF1 PCK1 PCK2 PCM1 PCYT1B PDAP1 PDCD7 PDE1A PDE4D PDE6H PDIA3 PDK3 PDPK1 PDS5B PDSS2 PDYN PDZD4 PDZD9 PDZK1 PEG3 PELI3 PES1 PEX2 PFKFB1 PFKL PGM1 PGM3 PHACTR4 PHAF1 PHF20L1 PHF7 PHF8 PHGDH PHLDA1 PHLDA3 PHYH PHYHD1 PI4K2A PIBF1 PIGG PIGO PIK3R2 PIK3R5 PIKFYVE PIM1 PIMREG PIN1 PINX1 PIP4K2C PIP5K1A PKM PKNOX1 PLA1A PLA2G4C PLA2G4D PLAAT1 PLAAT5 PLAT PLBD1 PLCD1 PLCD4 PLEKHF2 PLEKHG2 PLEKHJ1 PLEKHO2 PLIN3 PLK1 PLK2 PLPP3 PLRG1 PLS3 PLSCR1 PNKD PNKP PNMA8A PNPO PNRC2 POGK POGZ POLA2 POLD3 POLDIP2 POLE3 POLH POLI POLL POLR2F POLR2K POLR3C POMC POMGNT2 POMZP3 POP7 POU2AF2 POU2F1 PP2D1 PPAN PPARG PPFIBP2 PPHLN1 PPIA PPID PPIL2 PPP1CC PPP1R10 PPP1R14A PPP1R17 PPP1R3C PPP1R8 PPP2R5C PPP2R5E PPP3CC PPP5C PPP6R2 PQBP1 PRAM1 PRDM16-DT PRDX2 PRDX5 PRICKLE2 PRKAB1 PRKCD PRKCG PRKCI PRKRIP1 PROSER2 PRPF38A PRPF4 PRPSAP2 PRR14 PRR15 PRR16 PRRC1 PRRC2B PRSS2 PRSS23 PRSS3 PRSS33 PRXL2A PSAT1 PSEN1 PSEN2 PSMA1 PSMA5 PSMA7 PSMB4 PSMC1 PSMD11 PSMD4 PSMD5 PSME1 PSME2 PSRC1 PTBP1 PTBP3 PTGDR PTGIS PTGR3 PTK2 PTK6 PTMS PTP4A1 PTPA PTPN12 PTPN7 PTPRO PTTG2 PUM3 PURG PUS7L PUSL1 PWP1 PYCR2 PYM1 PYROXD1 QARS1 QKI QPCTL QTMAN R3HDML RAB10 RAB11B RAB13 RAB14 RAB1B RAB26 RAB27A RAB28 RAB2B RAB35 RAB38 RAB39A RAB3A RAB3D RAB40B RAB43 RAB5C RAB7B RAB8B RABL3 RAD51AP1 RAD51C RAG1 RAI2 RALGPS1 RAP1B RAPGEFL1 RASA1 RASA3 RASGRP2 RASGRP3 RASL10B RASL11B RASL12 RASSF3 RASSF8 RBCK1 RBM11 RBM34 RBM39 RBM42 RBM4B RBM8A RBPJ RBPJL RBX1 RCAN1 RCBTB1 RCOR3 RD3 REG1A RETREG1 RETSAT REV3L RFWD3 RFX5 RGL1 RGS1 RGS10 RGS14 RGS18 RGS3 RGS5 RIMS4 RING1 RIOK1 RIOK2 RIOX2 RIT2 RITA1 RLBP1 RMND5A RMP24 RNASE11 RNF11 RNF115 RNF123 RNF138 RNF151 RNF183 RNF185 RNF32 RNF34 RNF41 RNPC3 ROBO3 ROPN1L ROR1 RP9 RPA2 RPA4 RPAP3 RPF2 RPL11 RPL12 RPL23 RPL30 RPL31 RPL34 RPL36 RPL37 RPL37A RPL3L RPL41 RPS10 RPS11 RPS12 RPS14 RPS16 RPS18 RPS19 RPS20 RPS21 RPS25 RPS26 RPS27A RPS6KA5 RPS6KA6 RPS6KB1 RPS9 RPUSD2 RRAGB RRP15 RSL1D1 RSPH10B2 RSPH3 RSRC2 RSRP1 RSU1 RTF1 RTKN RTL8A RTL8C RUFY3 RUSC1 RUVBL2 RWDD2B RXFP3 S100A16 S100A8 S1PR1 SAE1 SAMHD1 SANBR SAR1A SART1 SASH3 SAXO4 SCAMP3 SCAND2P SCD SCEL SCO2 SCYL1 SDC1 SDF4 SEC24C SECISBP2 SENP1 SENP2 SEPTIN1 SEPTIN12 SEPTIN5 SEPTIN9 SERAC1 SERBP1 SERF1A SERP1 SERPINA3 SERPINB2 SERPIND1 SERTM1 SET SETBP1 SETD3 SEZ6L SF3A3 SF3B2 SF3B6 SGCG SGIP1 SGK2 SGK3 SH2D1B SH3BGRL3 SH3BP5 SH3GL2 SH3GLB1 SH3RF2 SHANK3 SHC1 SHC3 SHMT2 SHOC2 SIGIRR SIK2 SIRT5 SIRT7 SIVA1 SIX2 SKA3 SKAP1 SKAP2 SLAIN2 SLC17A5 SLC1A1 SLC22A6 SLC35B1 SLC38A2 SLC41A3 SLC48A1 SLC4A1AP SLC68A1 SLC7A1 SLCO2B1 SLFNL1 SLIT1-AS1 SLX4 SMAD1 SMAD3 SMAP1 SMARCB1 SMG5 SMIM11 SMTNL2 SMURF1 SMYD3 SNAI2 SNAP25 SNCA SNCB SND1 SNRNP35 SNRNP40 SNRNP70 SNURF SNX1 SNX17 SNX21 SNX27 SOCS3 SOCS5 SOD2 SOX5 SOX7 SP140L SP2 SPAG6 SPANXN3 SPART SPATA2 SPATA4 SPATA46 SPATA7 SPATS2 SPC24 SPEG SPIC SPINK6 SPINT2 SPMIP4 SPMIP9 SPON1 SPRR4 SPSB2 SPX SPZ1 SRARP SRP19 SRPK1 SRPK2 SRR SRRM2 SRRT SRSF1 SRSF3 SRSF6 SRSF8 SRSF9 SSB SSBP3 SSH3 SSTR2 ST3GAL6 ST6GALNAC6 STAC STARD10 STAT5B STAU1 STEEP1 STIP1 STK11 STK17B STK25 STK26 STK33 STK40 STN1 STOML1 STOML2 STOML3 STRIP2 STX11 STXBP1 SUB1 SULF1 SULT1A3 SUN5 SUPT4H1 SURF2 SUSD3 SYCP2L SYF2 SYK SYNCRIP SYNJ2BP SYT17 SYT6 SYVN1 TAB2 TACO1 TAF1 TAF11 TAF1B TAF6 TAF7L TAF9 TAF9B TAFA4 TAGLN2 TANK TAP2 TARBP2 TARDBP TASP1 TBC1D10C TBC1D20 TBC1D21 TBC1D26 TBC1D3P2 TBC1D7 TBC1D9B TBCC TBCD TBCK TBK1 TBPL1 TBX22 TCEA1 TCEA2 TCEAL2 TCEAL8 TCEANC TCEANC2 TCF19 TCL1B TCN2 TCP10L TCP10L3 TCP11 TCP11L1 TCP11L2 TEK TENM3-AS1 TEPSIN TERB2 TET3 TEX2 TEX44 TEX56P TFPI TFPT TGFB1 TGFB2 TGFBR2 TGIF1 TGM2 THAP1 THAP3 THAP4 THAP7 THBS1 THBS4 TICRR TIGAR TIGD1 TIMM17B TIMMDC1 TIPIN TIPRL TIRAP TK1 TLE3 TLL1 TM2D1 TMA16 TMA7 TMCC1 TMCC2 TMEM126B TMEM175 TMEM183A TMEM255A TMEM267 TMEM35A TMEM53 TMEM97 TMOD2 TMOD4 TMUB1 TMX3 TNFAIP8L1 TNFRSF14 TNFSF13B TNFSF14 TNIP2 TNNT2 TOB1 TOM1 TOM1L2 TOMM5 TOP1 TOX2 TP53BP2 TP53TG1 TP53TG5 TPD52L2 TPD52L3 TPH1 TPI1 TPMT TPPP TPRA1 TPRXL TPT1 TRAF3IP1 TRAF6 TRAIP TRAM1 TRAP1 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC9 TRDMT1 TRIB2 TRIB3 TRIM16 TRIM39 TRIM40 TRIM41 TRIM44 TRIM46 TRIM47 TRIM52 TRIM63 TRIM69 TRIML1 TRIR TRMT1L TRMT2A TRPT1 TRUB1 TSKS TSLP TSNAXIP1 TSPAN13 TSPAN5 TSPY2 TSPYL1 TSSC4 TSSK2 TSSK6 TTC23 TTC3 TTK TTLL6 TTLL7 TTPA TUBB TUBG1 TUT7 TWF1 TXNDC5 TYMSOS UBAC1 UBB UBE2DNL UBE2E2 UBE2G1 UBE2I UBE2M UBE2S UBE3A UBE3C UBL3 UBL4A UBQLN1 UBXN10 UBXN6 UBXN7 UCHL5 UGCG UGGT2 UGT1A10 ULK4 UNG UPF3A URI1 USE1 USF1 USP12 USP2 USP39 USP5 USP6 USP6NL UTP14A UTP23 UTP25 UTP4 UXT VAC14 VAMP3 VASH2 VAT1L VCY VCY1B VDAC2 VHL VIM VIPR2 VMA22 VPS29 VPS33B VPS35 VPS37A VPS37C VPS41 VSIG4 VTA1 VTN VWA5A WAC WARS1 WARS2 WASH2P WASH3P WASL WDR45 WDR45B WDR5 WDR88 WDR89 WNT4 WWC3 XAF1 XRN2 YAE1 YPEL3 YTHDF2 YWHAB YWHAG YWHAZ YY1 ZAP70 ZC2HC1A ZC3H3 ZC3HAV1 ZC3HAV1L ZC3HC1 ZCCHC12 ZCCHC17 ZCCHC8 ZDHHC23 ZDHHC7 ZEB2 ZFAND5 ZFC3H1 ZFP36 ZFYVE1 ZFYVE16 ZFYVE27 ZGRF1 ZHX2 ZKSCAN1 ZKSCAN8 ZMAT3 ZMAT4 ZMYM3 ZMYM5 ZNF133 ZNF181 ZNF197 ZNF2 ZNF22 ZNF224 ZNF227 ZNF23 ZNF302 ZNF322 ZNF331 ZNF334 ZNF343 ZNF35 ZNF365 ZNF385B ZNF410 ZNF423 ZNF449 ZNF473 ZNF483 ZNF486 ZNF565 ZNF574 ZNF581 ZNF583 ZNF584 ZNF605 ZNF606 ZNF619 ZNF622 ZNF641 ZNF660 ZNF684 ZNF706 ZNF740 ZNF747 ZNF75A ZNF836 ZNF839 ZNF92 ZNHIT1 ZRSR2 ZSCAN1 ZSCAN16 ZSCAN18 ZSCAN21 ZSCAN5A ZW10 ZWINT ZXDC	38 interacting genes: AP2A1 AP2A2 APP DPYSL2 EAF1 EGFR EPS15 FBXO7 FRS3 IQGAP1 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 NRON OLIG1 PALS1 PDZK1IP1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 SPANXN2 TERF2
Entrez ID		351	8650
HPRD ID		00100	04767
Ensembl ID		ENSG00000142192	ENSG00000133961
Uniprot IDs		A0A0A0MRG2 A0A140VJC8 B4DGD0 B4DJT9 E9PG40 P05067	P49757
PDB IDs		1AAP 1AMB 1AMC 1AML 1BA4 1BA6 1BJB 1BJC 1BRC 1CA0 1HZ3 1IYT 1MWP 1OWT 1QCM 1QWP 1QXC 1QYT 1TAW 1TKN 1X11 1Z0Q 1ZE7 1ZE9 1ZJD 2BEG 2BP4 2FJZ 2FK1 2FK2 2FK3 2FKL 2FMA 2G47 2IPU 2LFM 2LLM 2LMN 2LMO 2LMP 2LMQ 2LNQ 2LOH 2LP1 2LZ3 2LZ4 2M4J 2M9R 2M9S 2MGT 2MJ1 2MPZ 2MVX 2MXU 2NAO 2OTK 2R0W 2WK3 2Y29 2Y2A 2Y3J 2Y3K 2Y3L 3AYU 3BAE 3BKJ 3DXC 3DXD 3DXE 3GCI 3IFL 3IFN 3IFO 3IFP 3JQ5 3JQL 3JTI 3KTM 3L33 3L81 3MOQ 3MXC 3MXY 3NYJ 3NYL 3OVJ 3OW9 3PZZ 3Q2X 3SV1 3U0T 3UMH 3UMI 3UMK 4HIX 4JFN 4M1C 4MDR 4MVI 4MVK 4MVL 4NGE 4OJF 4ONF 4ONG 4PQD 4PWQ 4XXD 5AEF 5AM8 5AMB 5BUO 5C67 5CSZ 5HOW 5HOX 5HOY 5KK3 5LFY 5LV0 5MY4 5MYO 5MYX 5ONP 5ONQ 5OQV 5TXD 5VOS 5VZY 5W3P 6CO3 6GFI 6ITU 6IYC 6NB9 6O4J 6OC9 6OIZ 6RHY 6SHS 6SZF 6TI5 6TI6 6TI7 6W0O 6WXM 6XOV 6YHF 6YHI 6YHO 6YHP 6YHX 7B3J 7B3K 7E6P 7F29 7JXN 7JXO 7O1Q 7OW1 7OXN 7Q4B 7Q4M 7RTZ 7U4P 7WFY 7WVY 7Y3J 7Y8Q 8AZS 8AZT 8B9Q 8B9R 8BFA 8BFB 8BFZ 8BG0 8C3H 8EZD 8EZE 8FF2 8FF3 8H8Q 8I4O 8KEW 8KF1 8KF3 8KF4 8KF5 8KF6 8OL2 8OL3 8OL5 8OL6 8OL7 8OLG 8OLN 8OLO 8OLQ 8OT1 8OT3 8OT4 8OTF 8OVK 8OVM 8OWD 8OWE 8OWJ 8OWK 8QN6 8QN7 8SEJ 8SEK 8SEL 8T82 8T89 8X52 8X53 8X54 9CZN 9CZP 9IIO	5NJJ 5NJK
GO Terms Enriched among Interactors		Cytosol Cytoplasm Nucleus Nucleoplasm RNA Binding Macromolecule Metabolic Process Protein Serine Kinase Activity Nucleic Acid Metabolic Process Kinase Activity Protein Serine/threonine Kinase Activity Translation Protein Kinase Activity Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Protein Phosphorylation Regulation Of Protein Metabolic Process Nucleotide Binding Phosphorylation Nucleolus Protein Binding Ribosome Organelle Organization Focal Adhesion Amyloid-beta Binding Structural Constituent Of Ribosome Ribonucleoprotein Complex Cellular Response To Stress RNA Processing Transferase Activity MRNA Metabolic Process GTPase Activity Regulation Of Apoptotic Process Regulation Of Primary Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Signaling Pathway RRNA Metabolic Process GTP Binding Regulation Of Metabolic Process ATP Binding Mitochondrion Ribonucleoprotein Complex Biogenesis Negative Regulation Of Intracellular Signal Transduction Mitochondrial Large Ribosomal Subunit Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Protein Localization Regulation Of Protein Stability RRNA Binding Cellular Component Assembly	Diacylglycerol-dependent Serine/threonine Kinase Activity Enzyme Binding Plasma Membrane Receptor Internalization Positive Regulation Of Signaling Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Apical Plasma Membrane Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Regulation Of Protein Localization Regulation Of Signaling Negative Regulation Of Programmed Cell Death Endocytosis Intracellular Signal Transduction Regulation Of Biological Quality Regulation Of Superoxide Metabolic Process Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of MAPK Cascade Regulation Of Apoptotic Process Regulation Of Signal Transduction Cell Activation Negative Regulation Of Glial Cell Apoptotic Process Ubiquitin-protein Transferase Activity Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death AP-2 Adaptor Complex Positive Regulation Of Metabolic Process Regulation Of Cell Communication Receptor-mediated Endocytosis Regulation Of Vesicle-mediated Transport Apoptotic Process Positive Regulation Of Catabolic Process Extracellular Exosome Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Transport Programmed Cell Death Cell Death Negative Regulation Of Insulin Receptor Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Negative Regulation Of Cellular Response To Insulin Stimulus