IGFBP5 and PAPPA2

Number of citations: 0 (PubMedID 9883900)
Data Source: HPRD (in vitro)

		IGFBP5	PAPPA2
Name		insulin like growth factor binding protein 5	pappalysin 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex	Extracellular Region Extracellular Space Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Receptor Ligand Activity	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Osteoblast Differentiation Signal Transduction Female Pregnancy Cell Population Proliferation Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Migration Hair Follicle Morphogenesis Intracellular Signal Transduction Regulation Of Growth Glucose Homeostasis Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Growth Insulin-like Growth Factor Receptor Signaling Pathway Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mammary Gland Involution Response To Growth Hormone Cellular Response To CAMP Negative Regulation Of Muscle Tissue Development Negative Regulation Of Skeletal Muscle Hypertrophy Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Regulation Of Cell Growth Proteolysis Cell Surface Receptor Signaling Pathway Response To Salt Stress Bone Morphogenesis
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
GWAS		Blood protein levels ( 30072576 ) Breast cancer ( 29059683 ) Creatinine levels ( 29403010 ) Estimated glomerular filtration rate ( 30604766 ) FEV1 ( 30804560 ) Glomerular filtration rate ( 27588450 29403010 ) Glomerular filtration rate in non diabetics (creatinine) ( 26831199 ) Height ( 31562340 ) Hypothyroidism ( 27182965 ) Lung function (FEV1/FVC) ( 30804560 ) Metabolite levels ( 23823483 ) Mitral valve prolapse ( 26301497 ) Pulse pressure ( 27841878 ) Serum thyroid-stimulating hormone levels ( 25436638 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Visceral fat ( 22589738 )	Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Automobile speeding propensity ( 30643258 ) Birth weight ( 31043758 ) Body mass index ( 26426971 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273 ) Height ( 25429064 20881960 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Offspring birth weight ( 31043758 ) Pediatric central nervous system tumors (late onset)(pleiotropy) ( 33226468 ) Pediatric central nervous system tumors (pleiotropy) ( 33226468 ) Perioperative myocardial infarction in coronary artery bypass surgery ( 25948407 ) Pulse pressure ( 30578418 27841878 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )
Interacting Genes		100 interacting genes: ABHD4 ADAM12 AHNAK2 AMIGO1 ANKS6 APH1A AQP2 AQP6 AQP9 ARL13B ASGR1 BAG6 BIK BSND CD53 CERS4 CHODL CLDN2 CLDN20 CLDN6 CLDN7 CLDN9 CLEC17A CPLX4 CREB3 CXCR1 ELOVL5 ERGIC3 F2 FAM209A FCRL3 FFAR2 FHL1 FHL2 FKBP7 FN1 FNDC9 GJA5 GJA8 GJB3 GJB5 GOLM1 GPR151 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HSD17B13 IGF1 IGF2 IGFALS KCNK5 KIAA2013 KPNB1 LAPTM4B LAYN LDLRAD1 LHFPL1 LMNA LTBP1 MFF MRPS18B MS4A3 MS4A7 NCAPH2 PAPPA2 PDZK1IP1 PNO1 PROKR2 RASSF1 RHCG SAR1A SERPINE1 SLC10A6 SLC13A4 SLC35H1 SLC38A1 SLC41A2 SLC41A3 SLC61A1 SPAG4 SPP1 SYNE4 TF THAP4 THBS1 TIMMDC1 TLCD4 TMEM106A TMEM106C TMEM179B TMEM237 TMEM45A TMEM52B TMPRSS2 TMX2 TSPAN12 TSPO2 VTN	5 interacting genes: ATF7IP IGFBP3 IGFBP5 SMAD4 ZNF512B
Entrez ID		3488	60676
HPRD ID		00901	10156
Ensembl ID		ENSG00000115461	ENSG00000116183
Uniprot IDs		P24593	Q9BXP8
PDB IDs		1BOE 1H59 7UFG	8SL1
GO Terms Enriched among Interactors		Membrane Plasma Membrane Protein Binding Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Connexin Complex Gap Junction Channel Activity Bicellular Tight Junction Assembly Tight Junction Assembly Positive Regulation Of Blood Coagulation Gap Junction Tight Junction Organization Positive Regulation Of Coagulation Platelet Alpha Granule Lumen Endoplasmic Reticulum Lumen Water Channel Activity Transmembrane Transport Structural Molecule Activity Cell-cell Junction Assembly Anchoring Junction Insulin-like Growth Factor Ternary Complex Peptidase Inhibitor Complex Integrin Binding Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Water Transport One-carbon Compound Transport Positive Regulation Of Wound Healing	Insulin-like Growth Factor Binding Protein Complex Insulin-like Growth Factor Ternary Complex Insulin-like Growth Factor II Binding Osteoblast Differentiation Insulin-like Growth Factor Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Type B Pancreatic Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Fibronectin Binding Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Muscle Hypertrophy Growth Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Smooth Muscle Cell Migration Regulation Of MiRNA Transcription Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of MiRNA Metabolic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of Growth Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Cell Population Proliferation Cell Population Proliferation Regulation Of Smooth Muscle Cell Proliferation Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Epithelial Cell Proliferation Protein Tyrosine Phosphatase Activator Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Macromolecule Biosynthetic Process Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Negative Regulation Of Biosynthetic Process Sulfate Binding Endocardial Cell Differentiation Regulation Of Primary Metabolic Process MAPK Cascade Negative Regulation Of Growth Regulation Of Muscle System Process Transcription Regulator Complex SMAD Protein Complex