FAM131C and SFI1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		FAM131C	SFI1
Name		family with sequence similarity 131 member C	SFI1 centrin binding protein
Structure		No pdb structure
GO Annotations	Cellular Component	None	Cytoplasm Centriole Cytosol Cytoskeleton
GO Annotations	Molecular Function	Protein Binding	Protein Binding Phosphatase Binding
Pathways		None	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
GWAS		Cognitive performance ( 19734545 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 )	A body shape index ( 34021172 ) Age-related hearing impairment ( 24939585 ) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Fish- and plant-related diet ( 32066663 ) Lymphocyte count ( 32888494 ) Metabolite levels ( 23823483 ) Neutrophil percentage of white cells ( 32888494 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) Type 2 diabetes ( 31118516 )
Interacting Genes		12 interacting genes: APP CRYAA DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1 WWP2	15 interacting genes: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH GOLGA2 KRT19 LPXN MAD2L2 MDFI PPP1CA RADIL RBPMS SERTAD1
Entrez ID		348487	9814
HPRD ID		08779	11550
Ensembl ID		ENSG00000185519	ENSG00000198089
Uniprot IDs		Q96AQ9	A8K8P3
PDB IDs		Not available	2K2I
GO Terms Enriched among Interactors		Astrocyte Activation Involved In Immune Response Response To Heat Astrocyte Activation Central Nervous System Development Response To Temperature Stimulus Negative Regulation Of Signaling Microglial Cell Activation Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synapse Organization Protein Stabilization Positive Regulation Of Aspartic-type Peptidase Activity MAD1 Complex Regulation Of Cell Activation Macrophage Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Stability Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine	Microtubule Organizing Center Organization Telomere Maintenance In Response To DNA Damage Centriole Replication Cell Differentiation Involved In Embryonic Placenta Development Centriole Assembly Centriole Microtubule Nucleation Microtubule Cytoskeleton Organization Cell Division