FAM131C and DNAJA3

Number of citations: 0 (PubMedID 16189514)
Data Source: HPRD (two hybrid)

		FAM131C	DNAJA3
Name		family with sequence similarity 131 member C	DnaJ heat shock protein family (Hsp40) member A3
Structure		No pdb structure
GO Annotations	Cellular Component	None	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Neuromuscular Junction Mitochondrial Nucleoid Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding	Signaling Receptor Binding Type II Interferon Receptor Binding Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding Hsp70 Protein Binding GTPase Regulator Activity Heat Shock Protein Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding IkappaB Kinase Complex Binding DNA-binding Transcription Factor Binding
	Biological Process	None	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Immune System Process Mitochondrial DNA Replication Protein Folding Apoptotic Process Activation-induced Cell Death Of T Cells Response To Stress Mitochondrion Organization Small GTPase-mediated Signal Transduction Neuromuscular Junction Development Negative Regulation Of Cell Population Proliferation Response To Heat Positive Regulation Of Protein Ubiquitination T Cell Differentiation In Thymus Response To Type II Interferon Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Canonical NF-kappaB Signal Transduction Protein Stabilization Negative Regulation Of Type II Interferon-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Senescence
GWAS		Cognitive performance ( 19734545 ) Normal facial asymmetry (angle of surface orientation score) ( 30631343 )	Erectile dysfunction ( 30583798 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Immature fraction of reticulocytes ( 32888494 ) Schizophrenia ( 28991256 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226 )
Interacting Genes		12 interacting genes: APP CRYAA DNAJA3 EWSR1 GRN HPCAL4 LMO3 MAD1L1 NDN SFI1 VSNL1 WWP2	47 interacting genes: ATOSB ATXN1 BRCA1 CACNA1C CARM1 CATSPERT CIDEB COIL CYSRT1 FAM131C FBXO7 FOSL2 FRMD6 FXR1 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS LAMTOR5 MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 PTEN RAD51 RASA1 RELA RNF34 SHANK3 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22
Entrez ID		348487	9093
HPRD ID		08779	09758
Ensembl ID		ENSG00000185519	ENSG00000103423
Uniprot IDs		Q96AQ9	B3KM81 Q53G26 Q59E88 Q96EY1
PDB IDs		Not available	2CTT 2DN9 6IWS 7X89
GO Terms Enriched among Interactors		Astrocyte Activation Involved In Immune Response Response To Heat Astrocyte Activation Central Nervous System Development Response To Temperature Stimulus Negative Regulation Of Signaling Microglial Cell Activation Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synapse Organization Protein Stabilization Positive Regulation Of Aspartic-type Peptidase Activity MAD1 Complex Regulation Of Cell Activation Macrophage Activation Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Protein Stability Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Deactivation Of Mitotic Spindle Assembly Checkpoint Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex IkappaB Kinase Complex Binding Type II Interferon Receptor Binding Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Mitotic Cell Cycle Response To Norepinephrine	Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Regulation Of Cell Development Regulation Of Cell Differentiation Nucleoplasm Regulation Of RNA Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Nucleobase-containing Compound Metabolic Process P53 Binding Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Identical Protein Binding Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Positive Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Histone H3R2 Methyltransferase Activity Positive Regulation Of Nervous System Development Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Cell Differentiation Histone Arginine N-methyltransferase Activity Regulation Of Nervous System Development Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Neurogenesis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Primary Metabolic Process