IGFBP1 and MMP26

Number of citations: 0 (PubMedID 12119297)
Data Source: HPRD (in vitro, in vivo)

		IGFBP1	MMP26
Name		insulin like growth factor binding protein 1	matrix metallopeptidase 26
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Metalloendopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Growth Response To Insulin Tissue Regeneration Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Proteolysis Extracellular Matrix Organization Collagen Catabolic Process Negative Regulation Of Inflammatory Response
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	None
Drugs		None	Marimastat
GWAS		Major depressive disorder ( 23377640 ) Night sleep phenotypes ( 27126917 ) Offspring birth weight ( 31043758 ) Poor prognosis in Crohn's disease ( 28067912 ) Pulse pressure ( 28135244 30487518 ) Rheumatoid arthritis ( 21156761 ) Subjective response to lithium treatment in bipolar disorder ( 26503763 ) Systolic blood pressure ( 27618447 )	Coenzyme Q10 levels ( 27149984 ) Malaria ( 31844061 ) Mean corpuscular volume ( 28453575 )
Interacting Genes		4 interacting genes: IGF1 IGF2 MMP26 TF	4 interacting genes: ERRFI1 IGFBP1 MMP9 SERPINA1
Entrez ID		3484	56547
HPRD ID		00897	05683
Ensembl ID		ENSG00000146678	ENSG00000167346
Uniprot IDs		P08833	A0A8J8YUH5 Q9NRE1
PDB IDs		1ZT3 1ZT5 2DSQ	Not available
GO Terms Enriched among Interactors		Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Space Platelet Alpha Granule Lumen Striated Muscle Cell Differentiation Insulin Receptor Signaling Pathway Regulation Of Organ Growth Regulation Of Glucose Metabolic Process Positive Regulation Of T Cell Proliferation Muscle Cell Differentiation Negative Regulation Of Oocyte Development Extracellular Region Hormone Activity Regulation Of Mitotic Nuclear Division Receptor Ligand Activity Osteoblast Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Integrin Binding Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Trophectodermal Cell Proliferation Growth Factor Activity Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Nuclear Division Regulation Of Muscle Cell Differentiation Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Developmental Growth Positive Regulation Of Leukocyte Proliferation Regulation Of T Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Glycolate Metabolic Process Negative Regulation Of Inflammatory Response Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Alphav-beta3 Integrin-IGF-1-IGF1R Complex Prostate Gland Stromal Morphogenesis Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration Positive Regulation Of Type B Pancreatic Cell Proliferation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Embryo Implantation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Response To Insulin Ficolin-1-rich Granule Lumen Regulation Of Epithelial Cell Differentiation Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Skeletal System Development Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Negative Regulation Of Signal Transduction Insulin-like Growth Factor I Binding Response To Peptide Hormone Negative Regulation Of Cell Communication Insulin-like Growth Factor Binding Insulin-like Growth Factor II Binding Negative Regulation Of Signaling Extracellular Space Endoplasmic Reticulum Lumen Response To UV-A Positive Regulation Of Keratinocyte Migration Regulation Of Protein Phosphorylation Cellular Response To UV-A Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Limb Joint Morphogenesis Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Extracellular Matrix Regulation Of Phosphorylation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Lung Epithelium Development Cellular Response To Lipid Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of DNA Binding Cellular Response To Platelet-derived Growth Factor Stimulus