IGBP1 and REXO5

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		IGBP1	REXO5
Name		immunoglobulin binding protein 1	RNA exonuclease 5
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleolus Extracellular Exosome
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase 2A Binding	Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Regulation Of Dephosphorylation Intracellular Signal Transduction B Cell Activation Regulation Of Microtubule-based Movement Response To Interleukin-1	RRNA 3'-end Processing
Diseases		Corpus callosum, agenesis of, with mental retardation, ocular coloboma and micrognathia	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		12 interacting genes: APP HSPB1 LINC01257 MID1 MID2 PPP2CA PPP4C PPP6C PYGM REXO5 S100A13 SHOX	1 interacting genes: IGBP1
Entrez ID		3476	81691
HPRD ID		02140	17433
Ensembl ID		ENSG00000089289	ENSG00000005189
Uniprot IDs		P78318	Q96IC2
PDB IDs		4IYP	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Interleukin-1 Production RAGE Receptor Binding Protein Serine/threonine Phosphatase Activity Protein Localization To Microtubule Response To Lead Ion Regulation Of Interleukin-1 Production Protein Homodimerization Activity Phosphoprotein Phosphatase Activity Regulation Of Intracellular Signal Transduction Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Protein Kinase C Signaling Protein Localization To Cytoskeleton Phosphoprotein Binding RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Positive Regulation Of Interleukin-1 Beta Production Regulation Of Carbohydrate Catabolic Process Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of ATP Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Axo-dendritic Transport Regulation Of Signal Transduction Regulation Of Purine Nucleotide Metabolic Process Endosome To Plasma Membrane Transport Vesicle Regulation Of Supramolecular Fiber Organization Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Extracellular Exosome Regulation Of Interleukin-1 Beta Production Protein Kinase C Inhibitor Activity Regulation Of Canonical NF-kappaB Signal Transduction Cytoskeleton Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Glycogen Phosphorylase Activity Regulation Of Microtubule Polymerization Or Depolymerization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Phosphatase Regulator Activity Regulation Of Stress-activated Protein Kinase Signaling Cascade Protein Phosphatase 2A Binding Regulation Of Dephosphorylation Inner Dynein Arm 9+2 Motile Cilium Dynein Intermediate Chain Binding Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Inner Dynein Arm Assembly Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Dynein Complex Regulation Of Microtubule-based Movement Microtubule Motor Activity