IFRD1 and HDAC2

Number of citations: 45 (PubMedID 12198164)
Data Source: HPRD (in vivo, in vitro)

		IFRD1	HDAC2
Name		interferon related developmental regulator 1	histone deacetylase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Sarcoplasm	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex ESC/E(Z) Complex Sin3-type Complex
	Molecular Function	None	Transcription Coregulator Binding Chromatin Binding RNA Binding Histone Deacetylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding Protein Lysine Deacetylase Activity Histone Binding Histone Deacetylase Binding NF-kappaB Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism Protein Decrotonylase Activity Histone Decrotonylase Activity Protein De-2-hydroxyisobutyrylase Activity Protein Lysine Delactylase Activity Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Myoblast Fate Determination Striated Muscle Tissue Development Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Axon Extension Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Fat Cell Differentiation Negative Regulation Of Collateral Sprouting Adipose Tissue Development	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Cardiac Muscle Hypertrophy Chromatin Organization Chromatin Remodeling Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Epidermal Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Neuron Projection Development Dendrite Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Caffeine Heterochromatin Formation Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Circadian Regulation Of Gene Expression Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Nicotine Protein Modification Process Response To Cocaine Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Fate Specification Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Ethanol Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Progesterone Receptor Signaling Pathway Response To Hyperoxia Hair Follicle Placode Formation Negative Regulation Of Dendritic Spine Development Eyelid Development In Camera-type Eye Fungiform Papilla Formation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Transforming Growth Factor Beta Stimulus Response To Alcohol Positive Regulation Of Male Mating Behavior Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Cellular Response To Dopamine Response To Amyloid-beta Regulation Of Stem Cell Differentiation
Pathways		None	p75NTR negatively regulates cell cycle via SC1 NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Regulation of MECP2 expression and activity MECP2 regulates neuronal receptors and channels FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination Potential therapeutics for SARS STAT3 nuclear events downstream of ALK signaling Negative Regulation of CDH1 Gene Transcription Factors involved in megakaryocyte development and platelet production Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs		None	Pravastatin Lovastatin Theophylline Valproic acid Valproic acid Simvastatin Atorvastatin Fluvastatin Aminophylline Decitabine Oxtriphylline Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Tixocortol Mocetinostat Entinostat Abexinostat Givinostat Pyroxamide
GWAS		Amyotrophic lateral sclerosis (age of onset) ( 22959728 ) Dental caries (decayed, missing and filled teeth) ( 31533690 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Mortality in heart failure ( 20400778 ) Osteoarthritis (hip) ( 23989986 ) Refractive error ( 32231278 )	Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308 ) Metabolite levels ( 23823483 )
Interacting Genes		7 interacting genes: CSNK2A1 HDAC2 HDAC4 KLHL41 MYOD1 PDE4B RIT1	97 interacting genes: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CEBPA CHFR CIRSR CSNK2A1 CSNK2A2 CTBP1 CUL4B CYTOR DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 ERCC6 FKBP3 GATA3 H2AC1 H2AC20 H2BC21 H3-4 H3C1 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HOPX IFRD1 IKZF1 IKZF4 ING1 JUP MAD1L1 MBD2 MTA1 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUMO2 SUV39H1 SYK TFCP2 THRA THRB TMEM132D TOP2A TOP2B TP53 UBC USP4 VHL YY1 ZBTB16 ZNF461
Entrez ID		3475	3066
HPRD ID		04612	05521
Ensembl ID		ENSG00000006652	ENSG00000196591
Uniprot IDs		A4D0U1 O00458	Q92769
PDB IDs		Not available	3MAX 4LXZ 4LY1 5IWG 5IX0 6G3O 6WBW 6WBZ 6WHN 6WHO 6WHQ 6WHZ 6WI3 6XDM 6XEB 6XEC 7JS8 7KBG 7KBH 7LTG 7LTK 7LTL 7MOS 7MOT 7MOX 7MOY 7MOZ 7ZZO 7ZZP 7ZZR 7ZZS 7ZZT 7ZZU 7ZZW 8A0B 8BPA 8BPB 8BPC 8C60 9DTQ
GO Terms Enriched among Interactors		Negative Regulation Of Transcription By Competitive Promoter Binding Protein Lysine Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sin3-type Complex Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cardiac Muscle Hypertrophy Muscle Hypertrophy Regulation Of Myoblast Proliferation DNA-binding Transcription Activator Activity Muscle System Process Histone Deacetylase Complex Regulation Of Cell Population Proliferation Regulation Of Myotube Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Male Mating Behavior Promoter-specific Chromatin Binding Regulation Of Myoblast Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To Lipid Protein De-2-hydroxyisobutyrylase Activity Myoblast Fate Determination Negative Regulation Of Relaxation Of Cardiac Muscle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone Deacetylase Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Protein Decrotonylase Activity Histone Decrotonylase Activity Positive Regulation Of SnRNA Transcription By RNA Polymerase II Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Muscle Cell Differentiation Positive Regulation Of Aggrephagy Hair Follicle Placode Formation Histone Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Hydrolase Activity Protein Metabolic Process Protein Modification Process DNA-binding Transcription Factor Binding Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Dopamine	Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Chromatin Remodeling DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Transcription Corepressor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Sin3-type Complex Histone Deacetylase Binding Chromatin Binding Positive Regulation Of Metabolic Process Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Stem Cell Population Maintenance RNA Polymerase II-specific DNA-binding Transcription Factor Binding Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Transcription Repressor Complex Negative Regulation Of Developmental Process Negative Regulation Of Gene Expression, Epigenetic Heterochromatin Formation Protein-containing Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Cell Differentiation