IRF8 and ZBTB17

Number of citations: 0 (PubMedID 12904288)
Data Source: BioGRID (two hybrid), HPRD (in vivo, two hybrid)

		IRF8	ZBTB17
Name		interferon regulatory factor 8	zinc finger and BTB domain containing 17
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Protein-containing Complex Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Germinal Center B Cell Differentiation Follicular B Cell Differentiation Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Response To Bacterium Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Type II Interferon Dendritic Cell Differentiation Defense Response To Other Organism	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Regulation Of Cytokine Production Regulation Of Immune System Process Ectoderm Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G1 To G0 Transition
Pathways		Interferon gamma signaling Interferon alpha/beta signaling	XBP1(S) activates chaperone genes
GWAS		Aspartate aminotransferase levels ( 33547301 ) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199 ) Behcet's disease ( 33393726 ) Chronic lymphocytic leukemia ( 21131588 24292274 28165464 23770605 26956414 ) Composite immunoglobulin trait (IgA/IgM) ( 28628107 ) Diabetic retinopathy ( 21441570 ) Gestational age at birth (maternal effect) ( 27490719 ) Granulocyte count ( 27863252 ) Granulocyte percentage of myeloid white cells ( 27863252 ) HDL cholesterol levels ( 32203549 ) Inflammatory bowel disease ( 23128233 ) Limited cutaneous systemic scleroderma ( 29293537 ) Lymphocyte percentage of white cells ( 32888494 ) Major depressive disorder ( 23857890 ) Major depressive disorder x sex interaction ( 34099189 ) Monocyte count ( 27863252 32888494 23314186 28193307 29403010 ) Monocyte percentage of white cells ( 27863252 32888494 ) Multiple sclerosis ( 31604244 19525953 24076602 21833088 ) Neutrophil count ( 32888494 27863252 ) Neutrophil percentage of white cells ( 27863252 32888494 ) PR interval ( 32439900 ) Primary biliary cirrhosis ( 22961000 ) Rheumatoid arthritis ( 24390342 23143596 22446963 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Severe insulin-deficient type 2 diabetes ( 34737425 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) Systemic lupus erythematosus ( 28714469 27399966 26663301 26502338 33272962 19838195 ) Systemic lupus erythematosus and Systemic sclerosis ( 23740937 ) Systemic sclerosis ( 31672989 21779181 ) Systemic sclerosis (anti-centromere-positive) ( 29293537 ) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655 ) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020 ) Ulcerative colitis ( 32072174 23511034 )	Dilated cardiomyopathy ( 33495596 ) Dilated cardiomyopathy (MTAG) ( 33495596 ) Erectile dysfunction ( 30583798 ) Glomerular filtration rate ( 29403010 ) Heel bone mineral density ( 30598549 ) Idiopathic dilated cardiomyopathy ( 21459883 )
Interacting Genes		12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17	28 interacting genes: BCL6 CDKN2B CREBBP DIS3 DNMT3A E2F6 EP300 ESR1 ESR2 GTF2I HCFC1 HK2 HK3 HSPB1 IRF8 ITGB5 MAX MSX2 MYC MYCN PGR TMPRSS11A TOPBP1 TRIM55 TRIM63 VHL ZBTB7C ZBTB8A
Entrez ID		3394	7709
HPRD ID		03336	04968
Ensembl ID		ENSG00000140968	ENSG00000116809
Uniprot IDs		H3BRT4 Q02556	Q13105 Q53EM1
PDB IDs		Not available	2LVR 2LVT 2LVU 2M0D 2M0E 2M0F 2N25 2N26 2Q81 3M52 4U2M 4U2N 5ION 7AZW 7AZX 7MC1 7MC2 7MC3 7T58
GO Terms Enriched among Interactors		Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-12 Production Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Canonical NF-kappaB Signal Transduction NF-kappaB P50/p65 Complex DNA-templated Transcription Regulation Of Innate Immune Response Response To Virus Negative Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Non-canonical NF-kappaB Signal Transduction Follicular B Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of RNA Metabolic Process Defense Response To Virus Toll-like Receptor Signaling Pathway Transcription Coactivator Binding Regulation Of Cytokine Production Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Defense Response Cellular Response To Nicotine Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Metabolic Process Defense Response To Tumor Cell Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response Regulation Of Immune Response Cytokine-mediated Signaling Pathway Defense Response Antiviral Innate Immune Response Actinin Binding Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Positive Regulation Of Type I Interferon Production Sequence-specific DNA Binding Immune System Process Positive Regulation Of Defense Response Cellular Response To Lipid	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Transcription Coactivator Binding Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Chromatin Organization DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Estrogen Response Element Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Decreased Oxygen Levels Chromatin Chromatin Remodeling Regulation Of Gene Expression Response To Oxygen Levels Regulation Of Macromolecule Biosynthetic Process Histone H3K27 Acetyltransferase Activity Myc-Max Complex Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Steroid Receptor Activity Morphogenesis Of A Branching Structure Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Histone Acetyltransferase Complex Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process