CLEC4G and APOH

Number of citations: 0 (PubMedID 18624398)
Data Source: BioGRID (two hybrid)

		CLEC4G	APOH
Name		C-type lectin domain family 4 member G	apolipoprotein H
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Extracellular Region Extracellular Space Cell Surface Platelet Dense Granule Lumen Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Extracellular Exosome
	Molecular Function	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Polysaccharide Binding Pattern Recognition Receptor Activity Fructose Binding Carbohydrate Derivative Binding Virus Coreceptor Activity Glycosylated Region Protein Binding	Protein Binding Phospholipid Binding Heparin Binding Lipid Binding Lipase Binding Identical Protein Binding Lipoprotein Lipase Activator Activity
	Biological Process	T Cell Mediated Immunity Negative Regulation Of T Cell Mediated Immunity Immune Response Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Positive Regulation Of Viral Life Cycle	Negative Regulation Of Endothelial Cell Proliferation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Angiogenesis Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Plasminogen Activation Negative Regulation Of Myeloid Cell Apoptotic Process Triglyceride Transport Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Positive Regulation Of Triglyceride Metabolic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Platelet degranulation
Drugs		None	LJP 1082 Copper
GWAS		Post bronchodilator FEV1 ( 26634245 )	β2-Glycoprotein I (β2-GPI) plasma levels ( 23279374 ) Activated partial thromboplastin time ( 29403010 ) Alanine aminotransferase levels ( 34315874 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Blood pressure measurement (high sodium and potassium intervention) ( 24165912 ) Brain morphology (MOSTest) ( 32665545 ) Cardiometabolic and hematological traits ( 27668658 ) Coronary artery disease ( 29212778 ) Creatine kinase levels ( 29403010 ) LDL cholesterol ( 24097068 30275531 ) LDL cholesterol levels ( 30698716 32203549 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Lipoprotein (a) levels ( 33730874 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Presence of antiphospholipid antibodies ( 27098658 ) Systolic blood pressure ( 30224653 ) Thyroid stimulating hormone levels ( 32769997 ) Triglyceride levels ( 32203549 32154731 ) Triglycerides ( 30275531 )
Interacting Genes		27 interacting genes: APOA1 APOH ARL13B ARSA ASGR1 AZU1 CAPN1 CPLX4 CPN1 EBAG9 EIF6 FAM209A FTL GEM IFI35 LRRC4C MAP3K11 MT-CO1 NUP214 PKLR PRDX1 PTPN5 RPSA SHBG SIGLEC12 TNFAIP3 WBP2	14 interacting genes: AKT1 ANXA2 CDC42 CLEC4G F10 F12 GEM GRB2 LPA LRP2 LRP8 OGT PLG RBBP6
Entrez ID		339390	350
HPRD ID		16721	00728
Ensembl ID		ENSG00000182566	ENSG00000091583
Uniprot IDs		B7ZKQ2 Q08G24 Q6UXB4 Q6XYD1	A0A384NKM6 P02749
PDB IDs		Not available	1C1Z 1G4F 1G4G 1QUB 2KRI 3OP8 4JHS 6V06 6V08 6V09 6XSD 6XST 7JIK 7KG4
GO Terms Enriched among Interactors		Extracellular Exosome	Fibrinolysis Apolipoprotein Binding Proteolysis Serine-type Peptidase Activity Positive Regulation Of Fibrinolysis Plasma Membrane Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Positive Regulation Of Proteolysis Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Maturation Positive Regulation Of Plasminogen Activation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Positive Regulation Of TOR Signaling Glutamatergic Synapse Regulation Of Body Fluid Levels Low-density Lipoprotein Particle Receptor Activity Regulation Of Cell Migration Regulation Of Synapse Organization Regulation Of Plasminogen Activation Calcium Ion Binding Coagulation Blood Coagulation Regulation Of Fibrinolysis Regulation Of Cell Motility Hemostasis Protein Maturation Regulation Of Locomotion Regulation Of Multicellular Organismal Process Labyrinthine Layer Blood Vessel Development External Side Of Plasma Membrane Regulation Of Proteolysis Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process Regulation Of Wound Healing Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Spindle Midzone Positive Regulation Of Blood Coagulation Cargo Receptor Activity Blood Vessel Development Regulation Of TOR Signaling Positive Regulation Of Coagulation Embryonic Organ Development Placenta Blood Vessel Development Regulation Of Cell Adhesion