HTN1 and CCNT1

Number of citations: 66 (PubMedID 12832472)
Data Source: HPRD (two hybrid, in vivo)

		HTN1	CCNT1
Name		histatin 1	cyclin T1
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex P-TEFb Complex
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity SnRNA Binding Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Positive Regulation Of Metabolic Process Positive Regulation Of Cell-cell Adhesion Biomineral Tissue Development Killing Of Cells Of Another Organism Positive Regulation Of Vascular Wound Healing Defense Response To Bacterium Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Xenobiotic Stimulus Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Division
Pathways		Antimicrobial peptides	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Interactions of Tat with host cellular proteins SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation Estrogen-dependent gene expression
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487 )	Clozapine-induced agranulocytosis ( 25187353 )
Interacting Genes		1 interacting genes: CCNT1	24 interacting genes: AFF4 AHR BRD4 CDK9 ESR1 GRIPAP1 GRN GTF2F1 HEXIM1 HEXIM2 HIC2 HTATSF1 HTN1 KAT2B MDFIC MYC NCOA2 NUFIP1 PML POLR2A PRKCI PURA RN7SK SKP2
Entrez ID		3346	904
HPRD ID		00814	03938
Ensembl ID		ENSG00000126550	ENSG00000129315
Uniprot IDs		P15515	A8K4M5 O60563
PDB IDs		Not available	2PK2 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY 4OGR 4OR5 5L1Z 6CYT 6GZH 6W9E 6Z45 7NWK 8I0L 8K5R
GO Terms Enriched among Interactors		P-TEFb Complex 7SK SnRNA Binding Cyclin/CDK Positive Transcription Elongation Factor Complex Cyclin-dependent Protein Serine/threonine Kinase Activator Activity SnRNA Binding RNA Polymerase Binding Host-mediated Activation Of Viral Transcription Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Host-mediated Perturbation Of Viral Transcription Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Host-mediated Activation Of Viral Process Molecular Condensate Scaffold Activity Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Host-mediated Perturbation Of Viral Process Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Host-mediated Perturbation Of Symbiont Process Regulation Of Protein Serine/threonine Kinase Activity Modulation Of Process Of Another Organism DNA-binding Transcription Factor Binding	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression 7SK SnRNA Binding Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Elongation SnRNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Transcription Elongation Factor Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription Elongation By RNA Polymerase II Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process P-TEFb Complex Binding 7SK SnRNP Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction By P53 Class Mediator DNA-templated Transcription Rhythmic Process Transcription Regulator Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Transcription Coactivator Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Protein-containing Complex Positive Regulation Of Fibroblast Proliferation