HPCAL1 and HMG20A

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid, two hybrid), HPRD (two hybrid)

		HPCAL1	HMG20A
Name		hippocalcin like 1	high mobility group 20A
Structure			No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleus
	Molecular Function	Calcium Ion Binding Protein Binding Metal Ion Binding	DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of Protein Sumoylation Negative Regulation Of Neuron Differentiation
GWAS		Cerebral amyloid angiopathy x sex interaction in Alzheimer’s disease ( 34020725 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Kidney function decline traits ( 25493955 ) Lung function (FEV1/FVC) ( 30061609 ) Platelet distribution width ( 32888494 )	Fasting glucose ( 34059833 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Glycated hemoglobin levels ( 34059833 ) Hand grip strength ( 29691431 ) Hemoglobin A1c levels ( 29403010 ) Medication use (drugs used in diabetes) ( 31015401 ) Type 2 diabetes ( 21490949 21874001 22693455 22885922 24509480 28869590 30054458 30297969 30718926 32499647 )
Interacting Genes		39 interacting genes: AMOT ATXN1 C19orf44 C1QTNF2 CA3 CEBPA COLGALT2 CREM DTX2 EFEMP2 EPHB3 FZD7 GATA5 HMG20A IKBKG KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP4-2 KRTAP5-9 LITAF MDFI MICOS10-NBL1 MYDGF NBL1 NBPF19 NOTCH2NLA PLAAT2 SERPINI2 SLC34A1 TPSG1 VWC2 ZNF655	59 interacting genes: ADD1 AGR2 BACH2 BRAP C9orf72 CCDC136 CCNK CEP95 CFAP53 CREBBP DCTN4 DDIT4L DGCR6L DTNB DYRK1A FBXO7 FMNL1 FOXD4L1 FXR1 GADD45GIP1 GPSM1 GTF2A1L HPCAL1 KIFC3 KPNA2 KRT1 LMO1 LNX1 LURAP1 MAGOHB NTAQ1 NUTF2 OLIG3 PIAS2 PICK1 PSMB1 PSORS1C2 PSTPIP1 PTH2R QARS1 RAD54L2 RBM11 RBM7 RIN1 RPP30 RPRD1B RSPH9 RUSC1 SCNM1 SMAD4 SMYD1 SUOX SYTL4 TBC1D22B TCP11L1 TESC TRAF4 TRAPPC5 USHBP1
Entrez ID		3241	10363
HPRD ID		02564	16116
Ensembl ID		ENSG00000115756	ENSG00000140382
Uniprot IDs		O75544 P37235 Q6FGY1	B4DMG1 Q9NP66
PDB IDs		5T7C	Not available
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Identical Protein Binding Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process	Protein Binding