HOXD13 and MEIS1

Number of citations: 77 (PubMedID 16087734)
Data Source: HPRD (in vivo, two hybrid)

		HOXD13	MEIS1
Name		homeobox D13	Meis homeobox 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Pattern Specification Process Anterior/posterior Pattern Specification Gland Morphogenesis Embryonic Limb Morphogenesis Male Genitalia Development Prostate Gland Development Response To Testosterone Limb Morphogenesis Regulation Of Cell Population Proliferation Embryonic Digit Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Hindgut Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Morphogenesis Of An Epithelial Fold Branch Elongation Of An Epithelium Regulation Of Branching Involved In Prostate Gland Morphogenesis	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of DNA-templated Transcription Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Definitive Hemopoiesis Cell Growth Involved In Cardiac Muscle Cell Development
Pathways		None	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Diseases		Synpolydactyly Syndactyly Brachydactyly, including: type A; type B; type D; type E Brachydactyly-syndactyly syndrome	None
GWAS		Male-pattern baldness ( 28196072 )	Adolescent idiopathic scoliosis ( 28334814 ) Apolipoprotein A1 levels ( 32203549 ) Chronotype ( 30696823 ) Coffee consumption ( 31046077 ) Colorectal cancer (diet interaction) ( 24743840 ) Early spontaneous preterm birth ( 31194736 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Endometriosis ( 27506219 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Glaucoma (primary open-angle) ( 29891935 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Insomnia ( 32332799 27992416 ) Insomnia complaints ( 28604731 ) Insomnia complaints (continuous) ( 28604731 ) Insomnia complaints (dichotomous) ( 28604731 ) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566 ) Insomnia symptoms (never/rarely vs. usually) ( 30804566 ) Intraocular pressure ( 29785010 ) Mean platelet volume ( 32888494 ) Metabolite levels ( 23823483 ) Morning person ( 30696823 ) Photic sneeze reflex ( 27182965 ) Platelet count ( 32888494 ) PR interval ( 20062060 30679814 32439900 21347284 30046033 23139255 ) PR segment duration ( 24850809 ) Relative amplitude of rest-activity cycles ( 30120083 ) Resting heart rate ( 27798624 ) Restless legs syndrome ( 17637780 33239738 29029846 21779176 ) Sleep activity levels ( 33075057 ) Sleep duration ( 30531941 ) Sleep start time ( 33075057 ) Sleep traits (multi-trait analysis) ( 27992416 ) Systolic blood pressure ( 30224653 30578418 ) Triglycerides ( 30275531 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 )
Interacting Genes		5 interacting genes: CREBBP MEIS1 SMAD1 SMAD2 SMAD5	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3239	4211
HPRD ID		00872	03442
Ensembl ID		ENSG00000128714	ENSG00000143995
Uniprot IDs		P35453	O00470
PDB IDs		Not available	4XRS 5EGO
GO Terms Enriched among Interactors		Transcription Regulator Complex Heteromeric SMAD Protein Complex Embryonic Pattern Specification SMAD Protein Complex I-SMAD Binding SMAD Protein Signal Transduction Homomeric SMAD Protein Complex Ureteric Bud Development Mesonephric Epithelium Development Osteoblast Fate Commitment Mesonephric Tubule Development Anti-Mullerian Hormone Receptor Signaling Pathway Kidney Epithelium Development Chromatin Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway DEAD/H-box RNA Helicase Binding Anatomical Structure Morphogenesis Co-SMAD Binding Primary MiRNA Processing Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cardiac Conduction System Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Positive Regulation Of RNA Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tube Development Epithelium Development Intracellular Signaling Cassette MiRNA Processing RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Tau Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Male Germ Cell Nucleus Positive Regulation Of Biosynthetic Process Cardiac Muscle Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Intracellular Iron Ion Homeostasis Bone Development Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Chromatin Binding	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Chromatin Regionalization Pattern Specification Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Embryonic Skeletal System Morphogenesis Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Skeletal System Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Skeletal System Development Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Animal Organ Development Prostate Gland Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Developmental Process Regulation Of Macromolecule Metabolic Process Nucleus Proximal/distal Pattern Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Response To Testosterone Sequence-specific DNA Binding Embryonic Limb Morphogenesis System Development Gland Development Limb Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure