HOXA7 and GMNN

Number of citations: 0 (PubMedID 14973489)
Data Source: HPRD (in vitro)

		HOXA7	GMNN
Name		homeobox A7	geminin DNA replication inhibitor
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Histone Deacetylase Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Leukocyte Migration Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Stem Cell Differentiation	Regulation Of DNA Replication Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Replication Animal Organ Morphogenesis Regulation Of DNA-templated DNA Replication Initiation Positive Regulation Of Chromatin Binding Negative Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly DNA Replication Preinitiation Complex Assembly Negative Regulation Of DNA-templated DNA Replication
Pathways		None	Assembly of the pre-replicative complex Activation of the pre-replicative complex Switching of origins to a post-replicative state
GWAS		No GWAS studies recorded	Metabolite levels ( 23823483 )
Interacting Genes		6 interacting genes: GMNN JUNB MEIS1 NPM1 PEX5 SDCBP	34 interacting genes: ARNT AURKA CASP3 CDC20 CDKN1A CDKN2A CDT1 CEBPA CSNK2A1 FZR1 GLIS2 HOXA10 HOXA11 HOXA7 HOXB7 HOXC8 HOXC9 HOXD10 IMPDH1 KANK2 KAT7 LNX1 MCM6 NCF1 PHC1 PTPN11 REPIN1 RNF2 SAPCD2 SCMH1 SIX3 SMARCA4 ZNF250 ZNF439
Entrez ID		3204	51053
HPRD ID		00838	06783
Ensembl ID		ENSG00000122592	ENSG00000112312
Uniprot IDs		P31268	O75496
PDB IDs		Not available	1T6F 1UII 2LP0 2WVR 4BRY 7KLZ
GO Terms Enriched among Interactors		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Osteoclast Proliferation Regulation Of RNA Biosynthetic Process Transcription Factor AP-1 Complex Regulation Of Cell Cycle Myeloid Leukocyte Differentiation Chromatin Binding Negative Regulation Of Cellular Component Organization Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Regulation Of Growth Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Regulation Of Endoribonuclease Activity Protein-DNA Complex Assembly Ribosomal Large Subunit Export From Nucleus DNA-binding Transcription Factor Binding Positive Regulation Of Centrosome Duplication Granular Component Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Establishment Of Protein Localization To Membrane Peroxisome Membrane Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting Peroxisome Matrix Targeting Signal-1 Binding Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Interleukin-5 Receptor Binding Interleukin-5 Receptor Complex Positive Regulation Of Extracellular Exosome Assembly Regulation Of Extracellular Exosome Assembly Syndecan Binding Positive Regulation Of Chromatin Binding DNA Replication Preinitiation Complex Assembly Positive Regulation Of Cell Population Proliferation Embryonic Process Involved In Female Pregnancy Transcription Regulator Complex Myeloid Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Tat Protein Binding Regulation Of Organelle Assembly Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling	Negative Regulation Of Cell Cycle Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Phase Transition Anterior/posterior Pattern Specification Nucleus Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Skeletal System Morphogenesis Regulation Of Cell Cycle Process Proximal/distal Pattern Formation Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Embryonic Skeletal System Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Metabolic Process Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Regulation Of DNA-templated DNA Replication Initiation Regulation Of Mitotic Cell Cycle Phase Transition Chromatin Embryonic Organ Morphogenesis Regulation Of Mitotic Cell Cycle Nuclear Body Negative Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Developmental Process Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process