TLX1 and MEIS1

Number of citations: 0 (PubMedID 16357834)
Data Source: BioGRID (pull down), HPRD (in vitro)

		TLX1	MEIS1
Name		T cell leukemia homeobox 1	Meis homeobox 1
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of DNA-templated Transcription Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Definitive Hemopoiesis Cell Growth Involved In Cardiac Muscle Cell Development
Pathways		None	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)	None
GWAS		Mean spheric corpuscular volume ( 32888494 ) Refractive error ( 32231278 ) Regular attendance at a pub or social club ( 29970889 )	Adolescent idiopathic scoliosis ( 28334814 ) Apolipoprotein A1 levels ( 32203549 ) Chronotype ( 30696823 ) Coffee consumption ( 31046077 ) Colorectal cancer (diet interaction) ( 24743840 ) Early spontaneous preterm birth ( 31194736 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits (multivariate) ( 32602732 ) Endometriosis ( 27506219 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Glaucoma (primary open-angle) ( 29891935 ) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Height ( 28552196 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Insomnia ( 32332799 27992416 ) Insomnia complaints ( 28604731 ) Insomnia complaints (continuous) ( 28604731 ) Insomnia complaints (dichotomous) ( 28604731 ) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566 ) Insomnia symptoms (never/rarely vs. usually) ( 30804566 ) Intraocular pressure ( 29785010 ) Mean platelet volume ( 32888494 ) Metabolite levels ( 23823483 ) Morning person ( 30696823 ) Photic sneeze reflex ( 27182965 ) Platelet count ( 32888494 ) PR interval ( 20062060 30679814 32439900 21347284 30046033 23139255 ) PR segment duration ( 24850809 ) Relative amplitude of rest-activity cycles ( 30120083 ) Resting heart rate ( 27798624 ) Restless legs syndrome ( 17637780 33239738 29029846 21779176 ) Sleep activity levels ( 33075057 ) Sleep duration ( 30531941 ) Sleep start time ( 33075057 ) Sleep traits (multi-trait analysis) ( 27992416 ) Systolic blood pressure ( 30224653 30578418 ) Triglycerides ( 30275531 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500 )
Interacting Genes		11 interacting genes: CTF1 EIF4E MEIS1 MEIS2 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3195	4211
HPRD ID		01728	03442
Ensembl ID		ENSG00000107807	ENSG00000143995
Uniprot IDs		P31314	O00470
PDB IDs		Not available	4XRS 5EGO
GO Terms Enriched among Interactors		Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Phosphoprotein Phosphatase Activity Dephosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Phosphatase Type 2A Complex FAR/SIN/STRIPAK Complex Eye Development Response To Lead Ion Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Chromosome, Centromeric Region Sensory Organ Development Animal Organ Morphogenesis Chromatin Nucleus Tau Protein Binding Transcription Regulator Complex Developmental Process Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Glycogen Metabolic Process Myosin-light-chain-phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Transcription By RNA Polymerase II Regulation Of Microtubule Polymerization Circadian Regulation Of Gene Expression Negative Regulation Of Neuron Differentiation Response To Light Stimulus Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Leukemia Inhibitory Factor Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Neuron Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Differentiation Positive Regulation Of Cardiac Muscle Myoblast Proliferation Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Developmental Process	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Chromatin Regionalization Pattern Specification Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Embryonic Skeletal System Morphogenesis Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Skeletal System Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Skeletal System Development Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Animal Organ Development Prostate Gland Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Developmental Process Regulation Of Macromolecule Metabolic Process Nucleus Proximal/distal Pattern Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Response To Testosterone Sequence-specific DNA Binding Embryonic Limb Morphogenesis System Development Gland Development Limb Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure