HNF4G and HLF

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		HNF4G	HLF
Name		hepatocyte nuclear factor 4 gamma	HLF transcription factor, PAR bZIP family member
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Intercellular Bridge Mitotic Spindle	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		Regulation of gene expression in beta cells Nuclear Receptor transcription pathway	None
Drugs		Palmitic Acid	None
GWAS		Adult body size ( 32376654 ) Attention function ( 29907492 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 20935630 28892062 28448500 26426971 25673413 ) Body mass index (age <50) ( 26426971 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Body size at age 10 ( 32376654 ) Breast cancer ( 29059683 23535729 ) Chronotype ( 30696823 ) Estimated glomerular filtration rate ( 31152163 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Morning person ( 30696823 ) Number of sexual partners ( 30643258 ) Obesity ( 23563607 ) Pancreatic cancer ( 29422604 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Serum uric acid levels ( 30993211 29403010 ) Systolic blood pressure ( 27841878 ) Urate levels ( 23263486 31985003 31578528 ) Waist circumference adjusted for body mass index ( 28552196 )	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485 ) Bipolar disorder ( 31043756 33263727 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Platelet distribution width ( 32888494 ) Red blood cell count ( 32888494 ) Serum uric acid levels ( 30993211 ) Urate levels ( 23263486 31578528 31985003 ) Urate levels in obese individuals ( 25811787 ) Waist circumference ( 28552196 ) Weight ( 28552196 ) Zinc levels ( 26025379 )
Interacting Genes		15 interacting genes: COPS5 DNMT3L GAPDH HAX1 HLF NCOA1 NR0B2 NSD1 PNRC1 PNRC2 PRDX6 PSMC5 RANBP9 TNNI2 ZNF629	6 interacting genes: BMAL1 CREBBP DBP HNF4G MYB TET2
Entrez ID		3174	3131
HPRD ID		06909	00797
Ensembl ID		ENSG00000164749	ENSG00000108924
Uniprot IDs		F1D8Q4 Q14541	Q16534
PDB IDs		1LV2	Not available
GO Terms Enriched among Interactors		Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process P-body Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Catabolic Process Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Estrogen Receptor Binding RNA Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Rhythmic Process Nuclear Proteasome Complex Labyrinthine Layer Morphogenesis Macrophage Migration Inhibitory Factor Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Chromatin Peptidyl-cysteine S-nitrosylase Activity Thyrotropin-releasing Hormone Receptor Binding Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Female Receptivity Epigenetic Programing Of Female Pronucleus Peptidyl-cysteine S-nitrosylation GAIT Complex	Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Golgi Vesicle Docking Icosanoid Transmembrane Transporter Activity Glucuronoside Transmembrane Transporter Activity Glucuronoside Transport Energy Homeostasis Histone H3K27 Acetyltransferase Activity Positive Regulation Of Hepatic Stellate Cell Proliferation Myosin II Heavy Chain Binding Oxidative Stress-induced Premature Senescence Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Testosterone Secretion DNA 5-methylcytosine Dioxygenase Activity