HNF4G and PNRC1

Number of citations: 0 (PubMedID 15604093)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		HNF4G	PNRC1
Name		hepatocyte nuclear factor 4 gamma	proline rich nuclear receptor coactivator 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Intercellular Bridge Mitotic Spindle	P-body Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process
Pathways		Regulation of gene expression in beta cells Nuclear Receptor transcription pathway	None
Drugs		Palmitic Acid	None
GWAS		Adult body size ( 32376654 ) Attention function ( 29907492 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) Body mass index ( 20935630 28892062 28448500 26426971 25673413 ) Body mass index (age <50) ( 26426971 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body mass index in physically inactive individuals ( 28448500 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Body size at age 10 ( 32376654 ) Breast cancer ( 29059683 23535729 ) Chronotype ( 30696823 ) Estimated glomerular filtration rate ( 31152163 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Morning person ( 30696823 ) Number of sexual partners ( 30643258 ) Obesity ( 23563607 ) Pancreatic cancer ( 29422604 ) Pulse pressure ( 27841878 ) Red blood cell count ( 32888494 ) Serum uric acid levels ( 30993211 29403010 ) Systolic blood pressure ( 27841878 ) Urate levels ( 23263486 31985003 31578528 ) Waist circumference adjusted for body mass index ( 28552196 )	Height ( 31562340 )
Interacting Genes		15 interacting genes: COPS5 DNMT3L GAPDH HAX1 HLF NCOA1 NR0B2 NSD1 PNRC1 PNRC2 PRDX6 PSMC5 RANBP9 TNNI2 ZNF629	12 interacting genes: AR ESR2 ESRRG GRB2 HNF4A HNF4G MAPK8 NR5A2 RARB RARG RORA RORB
Entrez ID		3174	10957
HPRD ID		06909	08412
Ensembl ID		ENSG00000164749	ENSG00000146278
Uniprot IDs		F1D8Q4 Q14541	Q12796
PDB IDs		1LV2	Not available
GO Terms Enriched among Interactors		Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Receptor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process P-body Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Catabolic Process Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Estrogen Receptor Binding RNA Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Peptidyl-cysteine S-trans-nitrosylation Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Rhythmic Process Nuclear Proteasome Complex Labyrinthine Layer Morphogenesis Macrophage Migration Inhibitory Factor Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Chromatin Peptidyl-cysteine S-nitrosylase Activity Thyrotropin-releasing Hormone Receptor Binding Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Female Receptivity Epigenetic Programing Of Female Pronucleus Peptidyl-cysteine S-nitrosylation GAIT Complex	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Intracellular Signal Transduction Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Zinc Ion Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding DNA Binding Estrogen Response Element Binding Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cellular Response To Lipid Nuclear Steroid Receptor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Rhythmic Process Steroid Binding Regulation Of Circadian Rhythm Negative Regulation Of Cartilage Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Regulation Of Metabolic Process Glandular Epithelial Cell Development Regulation Of Gene Expression Regulation Of Chondrocyte Differentiation Nucleus Regulation Of Macromolecule Biosynthetic Process Response To Lipid Metal Ion Binding Regulation Of Primary Metabolic Process Cellular Response To Oxygen-containing Compound