HLA-DQA2 and HLA-DQB1

Number of citations: 0 (PubMedID 9036956)
Data Source: HPRD (in vitro, in vivo)

		HLA-DQA2	HLA-DQB1
Name		major histocompatibility complex, class II, DQ alpha 2	major histocompatibility complex, class II, DQ beta 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding MHC Class II Protein Complex Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Humoral Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling	Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Diseases		None	Systemic lupus erythematosus Graves' disease Hashimoto's thyroiditis Asthma Dilated cardiomyopathy (DCM) Viral myocarditis Tuberculosis Type I diabetes mellitus
GWAS		A body shape index ( 34021172 ) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Age at first birth ( 34211149 ) Alopecia areata ( 20596022 ) Asthma ( 21804548 31959851 31619474 ) Asthma and major depressive disorder ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Basal cell carcinoma ( 27539887 ) Body mass index ( 25673413 ) Chronic hepatitis B infection ( 24940741 ) Coffee consumption (cups per day) ( 31837886 ) Crohn's disease ( 23266558 26891255 21102463 ) Frailty index ( 34431594 ) Giant cell arteritis ( 28041642 ) Glycated hemoglobin levels ( 31213470 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Height ( 31562340 ) Hepatitis C (spontaneous viral clearance) ( 30593799 ) Hypothyroidism ( 22493691 ) IgA levels ( 28628107 ) IgE levels ( 22075330 23146381 ) IgG glycosylation ( 23382691 ) Inflammatory bowel disease ( 28067908 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Knee osteoarthritis ( 20305777 ) Low density lipoprotein cholesterol levels ( 33339817 ) Lung cancer in ever smokers ( 28604730 ) Lung function (FEV1) ( 28166213 ) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011 ) Lymphoma ( 23349640 ) Mild influenza (H1N1) infection ( 26379185 ) Mosquito bite size ( 28199695 ) Multiple sclerosis (OCB status) ( 23472185 ) Myositis ( 26291516 ) Narcolepsy ( 20711174 ) Peanut allergy ( 25710614 ) Pulmonary function (smoking interaction) ( 23284291 ) Red blood cell count ( 29403010 ) Response to hepatitis B vaccine ( 29534301 ) Rheumatoid arthritis ( 24782177 18668548 23918589 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Severe aplastic anemia ( 32004448 ) Sjögren's syndrome ( 28076899 ) Systemic lupus erythematosus ( 24871463 21408207 23053960 ) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781 ) Total cholesterol levels ( 33339817 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Type 2 diabetes ( 22693455 ) Ulcerative colitis ( 28067908 ) Vasculitis associated with antineutrophil cytoplasmic antibody reactive to myeloperoxidase ( 28029757 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	A body shape index ( 34021172 ) Acute-on-chronic liver failure in hepatitis B ( 28130311 ) Addison's disease ( 33574239 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 31361310 ) Allergic sensitization ( 23817571 ) Allergy ( 27182965 ) Alopecia areata ( 25608926 ) Anti-Epstein-Barr virus nuclear antigen (EBNA) IgG levels ( 30053915 ) Anti-varicella zoster virus IgG seropositivity ( 33204752 ) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 33768542 ) Asthma ( 21804548 30929738 31361310 31619474 31959851 34103634 ) Asthma (moderate or severe) ( 30552067 ) Asthma and hay fever ( 24388013 ) Asthma and major depressive disorder ( 31619474 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025 ) Automobile speeding propensity ( 30643258 ) Body size at age 10 ( 32376654 ) Bullous pemphigoid ( 34011352 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Cataracts (operation) ( 31816047 ) CCL19 levels ( 25147954 ) Celiac disease ( 20190752 ) Cervical cancer ( 28806749 ) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208 ) Childhood ear infection ( 28928442 ) Childhood steroid-sensitive nephrotic syndrome ( 29903748 31263063 ) Chronic hepatitis B infection ( 25802187 ) Chronic hepatitis C infection ( 24376798 ) Chronic lymphocytic leukemia ( 26956414 ) Chronic obstructive pulmonary disease ( 30804561 ) Crohn's disease ( 23266558 26891255 30500874 ) Diastolic blood pressure ( 27618447 ) Drug-induced liver injury (flucloxacillin) ( 30661239 ) Eczema ( 31361310 ) Emphysema imaging phenotypes ( 26030696 ) Enteric fever ( 25383971 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 ) Epstein-Barr virus immune response (EBNA-1) ( 23326239 ) FEV1 ( 30804560 ) Follicular lymphoma ( 20639881 21533074 ) Frailty index ( 34431594 ) Glucosuria ( 30476138 ) Glucosuria (moderate to severe) ( 30476138 ) HDL cholesterol levels ( 32203549 ) Head and neck squamous cell carcinoma ( 32276964 ) Height ( 31562340 ) Helicobacter pylori OMP antibody levels ( 33204752 ) Hepatitis B ( 21750111 28928442 ) Hepatitis C (spontaneous viral clearance) ( 30593799 ) Hepatocellular carcinoma in hepatitis C infection ( 28921602 ) High altitude adaptation ( 28373541 ) Hip circumference adjusted for BMI ( 34021172 ) HPV seropositivity ( 21896673 ) Hypothyroidism ( 22493691 27182965 ) IgA nephropathy ( 25305756 26028593 ) IgE levels ( 23146381 ) IgG levels ( 28628107 ) Immunoglobulin A vasculitis ( 28698626 ) Inflammatory bowel disease ( 28067908 ) Iron status biomarkers (iron levels) ( 28334935 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Kawasaki disease ( 33106546 ) Knee osteoarthritis ( 20305777 ) Late-onset myasthenia gravis ( 26562150 ) Latent autoimmune diabetes vs. type 1 diabetes ( 30254083 ) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 33339817 ) Lung cancer in ever smokers ( 28604730 ) Lung function (FEV1) ( 28166213 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Lung function (low FEV1 vs high FEV1) ( 26423011 ) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011 ) Lymphocyte percentage of white cells ( 27863252 ) Lymphoma ( 23349640 ) Mean corpuscular volume ( 32888494 ) Medication use (antihistamines for systemic use) ( 31015401 ) Medication use (drugs used in diabetes) ( 31015401 ) Medication use (thyroid preparations) ( 31015401 ) Mitochondrial heteroplasmy measurement ( 33731350 ) Moderate to vigorous physical activity levels ( 29899525 ) Mosquito bite size ( 28199695 ) Multiple sclerosis ( 20453840 ) Multiple sclerosis (OCB status) ( 23472185 ) Myositis ( 26291516 ) Nephropathy ( 21399633 ) Neuromyelitis optica ( 29769526 ) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526 ) Neutrophil count ( 32888494 ) Nodular sclerosis Hodgkin lymphoma ( 22086417 ) Oral cavity and pharyngeal cancer ( 27749845 ) Oral cavity cancer ( 32276964 ) Oropharynx cancer ( 27749845 ) Parkinson's disease ( 31660654 ) Peak expiratory flow ( 30804560 ) Peanut allergy ( 25710614 ) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575 ) Plantar warts ( 28928442 ) Pneumonia ( 28928442 ) Primary biliary cholangitis ( 19458352 20639880 ) Primary biliary cirrhosis ( 22961000 ) Prostate cancer ( 23535732 ) Pulmonary function ( 21946350 ) Pulmonary function (smoking interaction) ( 23284291 ) Red blood cell count ( 29403010 ) Response to hepatitis B vaccine ( 29534301 ) Rheumatic heart disease ( 32488134 ) Rheumatoid arthritis ( 23918589 24782177 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Scarlet fever ( 28928442 ) Schizophrenia ( 30285260 ) Self-reported allergy ( 23817569 ) Sero-negative rheumatoid arthritis ( 28706201 ) Serum IgE levels ( 25488688 ) Serum uric acid levels ( 30993211 ) Severe autoimmune type 2 diabetes ( 34737425 ) Shingles ( 28928442 ) Sjögren's syndrome ( 24097067 28076899 ) Strep throat ( 28928442 ) Systemic lupus erythematosus ( 24871463 26316170 26502338 26606652 ) Systemic sclerosis ( 20383147 21779181 ) Takayasu arteritis ( 23830517 ) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781 ) Tonsillectomy ( 28928442 ) Total cholesterol levels ( 33339817 ) Triglyceride levels ( 32203549 ) Tuberculosis ( 28928442 29036319 ) Type 1 diabetes ( 31152121 ) Type 1 diabetes (age at diagnosis) ( 33179336 ) Type 2 diabetes ( 30054458 ) Ulcerative colitis ( 19122664 23128233 24837172 28067908 ) Urate levels ( 31985003 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 ) Yeast infection ( 28928442 )
Interacting Genes		4 interacting genes: CD4 HLA-DQB1 INS LHFPL5	5 interacting genes: CD4 CD74 HLA-DQA1 HLA-DQA2 INS
Entrez ID		3118	3119
HPRD ID		09982	05054
Ensembl ID		ENSG00000237541	ENSG00000179344
Uniprot IDs		P01906 Q76NI6	P01920 Q5SU54 Q5Y7A9 Q5Y7D3 Q5Y7D6
PDB IDs		Not available	1JK8 1S9V 1UVQ 2NNA 4D8P 4GG6 4OZF 4OZG 4OZH 4OZI 5KSU 5KSV 6DIG 6XP6 7KEI 7SG1 7SG2 8VSP
GO Terms Enriched among Interactors		MHC Class II Protein Complex Binding Clathrin-coated Endocytic Vesicle Membrane MHC Class II Receptor Activity MHC Class II Protein Complex Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Peptide Antigen Binding Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Antigen Processing And Presentation Of Exogenous Antigen Transport Vesicle Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation ER To Golgi Transport Vesicle Membrane Antigen Processing And Presentation Of Peptide Antigen Endocytic Vesicle Membrane Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Interleukin-16 Binding Interleukin-16 Receptor Activity Helper T Cell Enhancement Of Adaptive Immune Response Regulation Of Immune System Process Antigen Processing And Presentation Positive Regulation Of Multicellular Organismal Process Trans-Golgi Network Membrane Golgi Membrane Regulation Of Cell Activation Positive Regulation Of Immune Response Response To Methamphetamine Hydrochloride Negative Regulation Of Glycogen Catabolic Process Immune System Process Late Endosome Membrane Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cell Adhesion Immunoglobulin Binding Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Dendritic Spine Maintenance MHC Class II Protein Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction	MHC Class II Protein Complex Binding Clathrin-coated Endocytic Vesicle Membrane MHC Class II Protein Complex Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of T Cell Activation Transport Vesicle Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion ER To Golgi Transport Vesicle Membrane Adaptive Immune Response Regulation Of Immune Response Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Endocytic Vesicle Membrane MHC Class II Protein Binding Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Antigen Processing And Presentation MHC Class II Receptor Activity Trans-Golgi Network Membrane Positive Regulation Of Monocyte Differentiation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Viral Entry Into Host Cell Regulation Of Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Multicellular Organismal Process Golgi Membrane Regulation Of Cell Activation Regulation Of Monocyte Differentiation Positive Regulation Of Immune Response Regulation Of Viral Entry Into Host Cell Immune System Process Positive Regulation Of Viral Life Cycle Regulation Of Cell Adhesion Positive Regulation Of Canonical NF-kappaB Signal Transduction T Cell Selection Peptide Antigen Binding T Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Canonical NF-kappaB Signal Transduction