HK1 and VDAC2

Number of citations: 0 (PubMedID 8420959)
Data Source: HPRD (in vitro)

		HK1	VDAC2
Name		hexokinase 1	voltage dependent anion channel 2
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Membrane Raft	Acrosomal Vesicle Nucleus Mitochondrion Mitochondrial Outer Membrane Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Sperm Midpiece
	Molecular Function	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Mannokinase Activity Peptidoglycan Binding Glucosamine Kinase Activity	Nucleotide Binding Voltage-gated Monoatomic Ion Channel Activity Protein Binding ATP Binding Oxysterol Binding Lipid Binding Voltage-gated Monoatomic Anion Channel Activity Porin Activity Cholesterol Binding Phospholipid Scramblase Activity Phosphatidylcholine Binding Ceramide Binding
	Biological Process	Intracellular Glucose Homeostasis Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Mannose Metabolic Process Glycolytic Process Inflammatory Response GDP-mannose Biosynthetic Process Hexose Metabolic Process Organophosphate Metabolic Process Positive Regulation Of Interleukin-1 Beta Production Innate Immune Response Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis GDP-mannose Biosynthetic Process From Mannose Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process	Monoatomic Ion Transport Monoatomic Anion Transport Lipid Transport Binding Of Sperm To Zona Pellucida Plasma Membrane Phospholipid Scrambling Phospholipid Translocation Transmembrane Transport Mitochondrial Outer Membrane Permeabilization Monoatomic Anion Transmembrane Transport Mitochondrial Transmembrane Transport
Pathways		Synthesis of GDP-mannose Defective HK1 causes hexokinase deficiency (HK deficiency) Glycolysis	PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Mitochondrial calcium ion transport
Drugs		alpha-D-glucose 6-phosphate Beta-D-Glucose Phosphoaminophosphonic Acid-Adenylate Ester Lonidamine	Aluminium monostearate PRLX 93936
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency	None
GWAS		Apolipoprotein B levels ( 32203549 ) Birth weight ( 31043758 ) Glycated hemoglobin levels ( 34059833 19096518 31213470 29483669 28898252 20858683 ) Glycemic traits (pregnancy) ( 23903356 ) HDL cholesterol levels ( 32203549 ) Hematocrit ( 19862010 32888494 27863252 ) Hemoglobin ( 32888494 19862010 ) Hemoglobin A1c levels ( 29844224 31217584 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 28017375 32327693 ) hemolysis of donated blood (osmotic) ( 34014839 ) High light scatter reticulocyte count ( 32888494 27863252 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Iris color (a* coordinate) ( 29109912 ) Iris color (b* coordinate) ( 29109912 ) Iron status biomarkers (ferritin levels) ( 33536631 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean corpuscular hemoglobin ( 20139978 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 20139978 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Offspring birth weight ( 31043758 ) Plateletcrit ( 32888494 ) Red blood cell count ( 27863252 32888494 20139978 ) Red blood cell traits ( 23222517 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	No GWAS studies recorded
Interacting Genes		6 interacting genes: APP CFTR ENO2 SCMH1 VDAC1 VDAC2	12 interacting genes: ADRB2 APP BAK1 CFTR CYCS DUX4 DUX4L9 ECT2 HK1 NEDD4 NEDD4L RPS3A
Entrez ID		3098	7417
HPRD ID		00809	01904
Ensembl ID		ENSG00000156515	ENSG00000165637
Uniprot IDs		A0A994J753 A8K7J7 B3KXY9 P19367 P78542 Q59FD4	A0A024QZT0 B4DKM5 P45880
PDB IDs		1CZA 1DGK 1HKB 1HKC 1QHA 4F9O 4FOE 4FOI 4FPA 4FPB	9EIH 9EII 9EIJ
GO Terms Enriched among Interactors		Membrane Raft Voltage-gated Monoatomic Anion Channel Activity Porin Activity Ceramide Binding Voltage-gated Monoatomic Ion Channel Activity Pore Complex Monoatomic Anion Transmembrane Transport Oxysterol Binding Monoatomic Anion Transport Mitochondrial Transmembrane Transport Phosphatidylcholine Binding Mitochondrial Transport Regulation Of Monoatomic Ion Transmembrane Transport Mitochondrial Nucleoid Cholesterol Binding Lipid Transport Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Enzyme Binding Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Monoatomic Ion Transport Response To CAMP Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Anion Channel Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monoatomic Anion Transport Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Calcium Import Into The Mitochondrion Recycling Endosome Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Transport Regulation Of Sodium Ion Transport Sodium Channel Inhibitor Activity Potassium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Transport Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Protein-folding Chaperone Binding Positive Regulation Of CAMP/PKA Signal Transduction Receptor Catabolic Process Neuronal Dense Core Vesicle Transmembrane Transporter Binding Negative Regulation Of Potassium Ion Transmembrane Transport Enzyme Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Endocytosis Ionotropic Glutamate Receptor Signaling Pathway Receptor-mediated Endocytosis Cell Junction Organization Response To Radiation Cellular Response To Radiation Negative Regulation Of Potassium Ion Transport Positive Regulation Of Macromolecule Metabolic Process Neuromuscular Junction Development Cytosol Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Chemical Homeostasis Regulation Of Cellular Localization Positive Regulation Of Metabolic Process Regulation Of CAMP/PKA Signal Transduction Import Into Cell Positive Regulation Of Cell Communication Glutamate Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Catabolic Process Positive Regulation Of Signaling Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Mini Excitatory Postsynaptic Potential