HGFAC and SPINT1

Number of citations: 0 (PubMedID 11013244)
Data Source: HPRD (in vitro, in vivo)

		HGFAC	SPINT1
Name		HGF activator	serine peptidase inhibitor, Kunitz type 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Rough Endoplasmic Reticulum Cytosol	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Blood Coagulation Zymogen Activation	Neural Tube Closure Embryonic Placenta Development Epidermis Development Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Epithelium Development Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		MET Receptor Activation	MET Receptor Activation Signaling by MST1
GWAS		Alanine aminotransferase levels ( 33547301 ) Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Aspartate aminotransferase levels ( 33547301 ) Blood protein levels ( 30072576 ) Coronary artery disease ( 29212778 ) Crohn's disease ( 26192919 ) Estimated glomerular filtration rate ( 31015462 31152163 ) Fibrinogen ( 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Gamma glutamyl transferase levels ( 29403010 33339817 ) Height ( 31562340 29782485 ) Hepatocyte growth factor levels ( 25998175 27989323 ) Inflammatory bowel disease ( 26192919 ) Iron status biomarkers (total iron binding capacity) ( 33536631 ) LDL cholesterol levels ( 32203549 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low density lipoprotein cholesterol levels ( 32154731 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Pulse pressure ( 27841878 30578418 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 32203549 30698716 29403010 33339817 32154731 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglycerides ( 30275531 )	Blood protein levels ( 30072576 ) Malaria ( 31844061 ) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738 )
Interacting Genes		10 interacting genes: APPBP2 CCHCR1 F2 GOLM1 HGF KLKB1 SLC30A2 SPINT1 SPINT2 VSIG1	23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5
Entrez ID		3083	6692
HPRD ID		05184	05494
Ensembl ID		ENSG00000109758	ENSG00000166145
Uniprot IDs		D6RAR4 Q04756	O43278
PDB IDs		1YBW 1YC0 2R0K 2R0L 2WUB 2WUC 3K2U	1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
GO Terms Enriched among Interactors		Regulation Of Fibrinolysis Serine-type Endopeptidase Activity Fibrinolysis Cell Morphogenesis Negative Regulation Of Neural Precursor Cell Proliferation Cellular Response To BMP Stimulus Epithelial Cell Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Regulation Of Glial Cell Differentiation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Extracellular Space Cellular Response To Growth Factor Stimulus Response To Growth Factor Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Endopeptidase Activity Factor XII Activation Tube Closure Serine-type Endopeptidase Inhibitor Activity Neural Tube Closure Regulation Of Neural Precursor Cell Proliferation Regulation Of Gliogenesis Coagulation Blood Coagulation Hemostasis Peptidase Inhibitor Activity Zinc Export Across Plasma Membrane Epithelial Cell Morphogenesis Involved In Placental Branching Serine-type Peptidase Activity Thrombospondin Receptor Activity Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Fibrinolysis Zinc Ion Import Into Lysosome Tube Formation Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Wound Healing Zinc:proton Antiporter Activity Proteolysis Growth Factor Activity Extracellular Region Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Wounding Regulation Of Branching Involved In Salivary Gland Morphogenesis Hepatocyte Growth Factor Receptor Signaling Pathway Vacuolar Transmembrane Transport	Positive Regulation Of Wound Healing Cell Surface Positive Regulation Of Monocyte Chemotactic Protein-1 Production Basal Part Of Cell