HARS1 and TNIK

Number of citations: 0 (PubMedID 17043677)
Data Source: BioGRID (two hybrid)

		HARS1	TNIK
Name		histidyl-tRNA synthetase 1	TRAF2 and NCK interacting kinase
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cytoskeleton Apical Plasma Membrane Recycling Endosome Extracellular Exosome Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity ATP Binding Ligase Activity Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation	MAPK Cascade Protein Phosphorylation Cytoskeleton Organization Nervous System Development Wnt Signaling Pathway Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Dendrite Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microvillus Assembly
Pathways		Cytosolic tRNA aminoacylation	Oxidative Stress Induced Senescence
Drugs		Histidine	Fostamatinib
GWAS		No GWAS studies recorded	Adolescent idiopathic scoliosis ( 28334814 ) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cerebrospinal fluid AB1-42 levels ( 29274321 ) Change in serum metabolite levels ( 31636271 ) Change in serum metabolite levels (CMS) ( 31636271 ) Cortical surface area (MOSTest) ( 32665545 ) Estimated glomerular filtration rate after 1 year in renal transplantation (recipient effect) ( 30920136 ) Frontotemporal dementia (age at onset) ( 29724592 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Hip circumference adjusted for BMI ( 28552196 ) LDL cholesterol ( 21347282 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Night sleep phenotypes ( 27126917 ) Response to antipsychotic treatment in schizophrenia ( 29503163 ) Subcortical volume (MOSTest) ( 32665545 ) Triglyceride levels ( 32154731 ) Type 2 diabetes ( 30054458 )
Interacting Genes		10 interacting genes: EEF1B2 EEF1G MTNR1B OGT PSMC5 RPL5 TARS1 TNIK TTC3 WEE2-AS1	39 interacting genes: ACTG1 AGTPBP1 AKAP9 ANK2 CLU CNKSR2 DPYSL2 DPYSL3 DST DYNC1H1 GOLGA4 GSE1 GSN HARS1 MACF1 NCK1 NCOR2 NEDD4 NEFM PAFAH1B1 PDE4DIP PPM1E PPP1R13B RAP2A SMARCE1 SMURF1 SNX6 SOS1 SPTBN1 SRGAP3 STRIP1 STRN4 SYNE1 TIAM2 TNKS TRAF2 TRIM2 TUBB2A WWC1
Entrez ID		3035	23043
HPRD ID		00827	18206
Ensembl ID		ENSG00000170445	ENSG00000154310
Uniprot IDs		B4DDD8 B4E1C5 P12081	Q9UKE5
PDB IDs		1X59 2LW7 4G84 4G85 4PHC 4X5O 5W6M 6O76 8YOR 8YP1	2X7F 5AX9 5CWZ 5D7A 6RA5 6RA7 7XZQ 7XZR 8WM0 8X88
GO Terms Enriched among Interactors		Translation Protein Metabolic Process Translation Elongation Factor Activity Translational Elongation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nuclear Proteasome Complex Regulation Of Proteolysis Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Eukaryotic Translation Elongation Factor 1 Complex Cytosol Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Proteasome-activating Activity Cytosolic Proteasome Complex Thyrotropin-releasing Hormone Receptor Binding Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Proteolysis Cytoplasmic Translation Positive Regulation Of Translation Negative Regulation Of Protein Neddylation Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Positive Regulation Of Microvillus Assembly Pre-mRNA 5'-splice Site Binding Extracellular Exosome Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Carbon Catabolite Regulation Of Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process MRNA 5'-splice Site Recognition	Cytoskeleton Organization Regulation Of Cellular Component Organization Cytoplasm Positive Regulation Of Cellular Component Organization Cytoskeleton Organelle Organization Retrograde Axonal Transport Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Cytosol Positive Regulation Of Cell Projection Organization Positive Regulation Of Axon Extension Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Positive Regulation Of Supramolecular Fiber Organization Structural Constituent Of Cytoskeleton Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Regulation Of Signal Transduction Axon Cytoplasm Regulation Of Plasma Membrane Bounded Cell Projection Organization Axonal Transport Regulation Of Cell Communication Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Biogenesis Regulation Of Axonogenesis Negative Regulation Of Hippo Signaling Axo-dendritic Transport Regulation Of Axon Extension Glutamatergic Synapse Regulation Of Protein-containing Complex Assembly Neurofibrillary Tangle Extrinsic Component Of Postsynaptic Density Membrane Cell Cortex Regulation Of Signaling Microtubule Cytoskeleton Organization Protein Localization To Plasma Membrane Potassium Channel Activator Activity Regulation Of Intracellular Signal Transduction Dihydropyrimidinase Activity Golgi To Plasma Membrane Protein Transport Maintenance Of Centrosome Location Cellular Localization Establishment Of Protein Localization Extracellular Exosome Supramolecular Fiber Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Protein Transport Microtubule Protein-macromolecule Adaptor Activity