HABP2 and COL4A3

Number of citations: 0 (PubMedID 1724753)
Data Source: HPRD (in vivo)

		HABP2	COL4A3
Name		hyaluronan binding protein 2	collagen type IV alpha 3 chain
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metalloendopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Proteolysis Cell Adhesion	Cell Adhesion Cell Surface Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation
Pathways		None	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs		Hyaluronic acid	None
Diseases		None	Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Cardiac troponin-I levels ( 31014085 ) Central corneal thickness ( 29760442 32528159 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Heel bone mineral density ( 28869591 ) Ischemic stroke ( 26732560 ) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954 ) Plasma factor VII activating protease levels ( 30070759 ) Urate levels ( 31578528 ) Waist-to-hip ratio adjusted for body mass index ( 28430825 )	Advanced age-related macular degeneration ( 26691988 ) Central corneal thickness ( 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Diabetic nephropathy in type 1 diabetes ( 31537649 ) Hematuria ( 30476138 ) Hematuria (moderate to severe) ( 30476138 ) Intraocular pressure ( 29235454 ) Kidney disease (end stage renal disease or albuminuria) in type 1 diabetes ( 31537649 ) Kidney disease (reduced eGFR and albuminuria or end stage renal disease) in type 1 diabetes ( 31537649 ) Macroalbuminuria in type 1 diabetes ( 31537649 ) Macular thickness ( 30535121 ) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000 ) Refractive error ( 32231278 ) Resting heart rate ( 27798624 )
Interacting Genes		7 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 KNG1	17 interacting genes: ANTXR2 APP CAMK2B CD93 CERT1 DCN FBLN2 FN1 HABP2 MATN2 MFAP2 MMP9 OSM SAA1 SERPINE2 TGFBI USH2A
Entrez ID		3026	1285
HPRD ID		04890	00354
Ensembl ID		ENSG00000148702	ENSG00000169031
Uniprot IDs		Q14520	Q01955
PDB IDs		Not available	5NB0 6WKU
GO Terms Enriched among Interactors		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Region Enzyme-linked Receptor Protein Signaling Pathway Glomerular Basement Membrane Development Neuromuscular Junction Development Cell Surface Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus Response To Amino Acid Signal Transduction Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Retinal Blood Vessel Morphogenesis Molecular Adaptor Activity Synapse Organization Platelet-derived Growth Factor Binding Retina Vasculature Morphogenesis In Camera-type Eye Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation Metalloendopeptidase Inhibitor Activity Angiogenesis Renal Tubule Morphogenesis Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process	Extracellular Region Extracellular Matrix Extracellular Matrix Structural Constituent Collagen Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparin Binding Peptidase Activator Activity Extracellular Space Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Developmental Process Platelet Alpha Granule High-density Lipoprotein Particle Regulation Of Cell Migration Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cell Motility Integrin Binding Regulation Of Locomotion Positive Regulation Of Synaptic Transmission Regulation Of Cell Differentiation Amyloid-beta Complex Signaling Receptor Binding Growth Cone Lamellipodium Regulation Of Monoatomic Ion Transport Regulation Of Response To Calcium Ion Regulation Of Synaptic Plasticity Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Inflammatory Response Regulation Of Multicellular Organismal Process Dendrite Development Identical Protein Binding Regulation Of Cell Adhesion Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development Intermembrane Sphingolipid Transfer Response To Wounding Regulation Of Developmental Process Cell Adhesion