HABP2 and COL4A2

Number of citations: 0 (PubMedID 1724753)
Data Source: HPRD (in vivo)

		HABP2	COL4A2
Name		hyaluronan binding protein 2	collagen type IV alpha 2 chain
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Collagen Trimer Collagen Type IV Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Molecular Adaptor Activity
	Biological Process	Proteolysis Cell Adhesion	Angiogenesis DNA-templated Transcription Response To Activity Negative Regulation Of Angiogenesis Extracellular Matrix Organization Endodermal Cell Differentiation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways		None	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization Attachment of bacteria to epithelial cells
Drugs		Hyaluronic acid	None
GWAS		Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226 ) Cardiac troponin-I levels ( 31014085 ) Central corneal thickness ( 29760442 32528159 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Heel bone mineral density ( 28869591 ) Ischemic stroke ( 26732560 ) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954 ) Plasma factor VII activating protease levels ( 30070759 ) Urate levels ( 31578528 ) Waist-to-hip ratio adjusted for body mass index ( 28430825 )	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 33547301 ) Apolipoprotein B levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Arterial stiffness ( 31070453 ) Arterial stiffness index ( 31235810 ) Blood urea nitrogen levels ( 31152163 ) Coronary artery calcification ( 22144573 ) Coronary artery disease ( 29212778 33020668 32469254 26343387 24262325 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Diastolic blood pressure ( 27841878 ) Fasting insulin ( 34059833 ) Glomerular filtration rate ( 29403010 ) Intake of sweets ( 31005972 ) LDL cholesterol ( 30275531 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 ) Maximum retinal arteriolar tortuosity ( 31597446 ) Middle temporal gyrus volume ( 31530798 ) Monocyte count ( 32888494 ) Myocardial infarction ( 26343387 ) Night sleep phenotypes ( 27126917 ) Non-lobar intracerebral hemorrhage ( 31430377 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Periventricular white matter hyperintensities ( 32517579 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Retinal arteriolar tortuosity ( 31597446 ) Septic shock (28-day mortality) ( 32755526 ) Serum alkaline phosphatase levels ( 33547301 ) Serum bilirubin levels x sex interaction in metabolic syndrome ( 30621171 ) Total cholesterol levels ( 30275531 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White matter hyperintensities ( 32358547 ) White matter hyperintensity burden ( 25663218 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )
Interacting Genes		7 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 KNG1	24 interacting genes: ANTXR2 ANXA7 APP ATF7IP BGN BMP3 CD93 COL4A1 CSNK2B DAZAP2 FBLN2 FN1 HABP2 MATN2 MMP9 OSM SAA1 SERPINE2 SKIL SMN1 TENT5A TGFBI TK1 VHL
Entrez ID		3026	1284
HPRD ID		04890	00355
Ensembl ID		ENSG00000148702	ENSG00000134871
Uniprot IDs		Q14520	P08572
PDB IDs		Not available	1LI1 5NAX 5NB2 6MPX
GO Terms Enriched among Interactors		Collagen Type IV Trimer Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen-activated Signaling Pathway Collagen Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Structural Constituent Extracellular Matrix Extracellular Structure Organization Extracellular Matrix Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Extracellular Region Enzyme-linked Receptor Protein Signaling Pathway Glomerular Basement Membrane Development Neuromuscular Junction Development Cell Surface Receptor Signaling Pathway Cellular Response To Amino Acid Stimulus Response To Amino Acid Signal Transduction Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Retinal Blood Vessel Morphogenesis Molecular Adaptor Activity Synapse Organization Platelet-derived Growth Factor Binding Retina Vasculature Morphogenesis In Camera-type Eye Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Endothelial Cell Proliferation Metalloendopeptidase Inhibitor Activity Angiogenesis Renal Tubule Morphogenesis Regulation Of Angiogenesis Regulation Of Vasculature Development Negative Regulation Of Multicellular Organismal Process	Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Organization Extracellular Structure Organization Protein Serine/threonine Kinase Binding Glycosaminoglycan Binding Basement Membrane Extracellular Matrix Binding Signaling Receptor Binding Integrin Binding Peptidase Activator Activity Heparin Binding Extracellular Space Collagen Binding Developmental Process Platelet Alpha Granule Identical Protein Binding High-density Lipoprotein Particle Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Amyloid Fibril Formation Angiogenesis Regulation Of Cell Differentiation Extracellular Exosome Calcium Ion Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Cell Differentiation Acute-phase Response Endodermal Cell Differentiation Oncostatin-M Receptor Binding Cerebellar Granular Layer Morphogenesis Mating Plug Formation Seminal Vesicle Epithelium Development